Imperial College London


Faculty of MedicineDepartment of Infectious Disease

Research Associate







Flowers buildingSouth Kensington Campus





Aline obtained her undergraduate degree in Molecular Medicine at the University of Sussex in 2008. She then completed her PhD in 2012 studying RbpA, RNA polymerase binding protein, a transcriptional activator in S. coelicolor in Dr. Mark Paget's group at the Department of Biochemistry at the University of Sussex.  

She is currently a research associate in the Wigneshweraraj group at the MRC Centre for Bacteriology & Infection. Her research is based on understanding the mechanisms by which phage-encoded small proteins inhibit the bacterial RNA polymerase. This study is aimed at developing new lead antibacterial compounds to target antibiotic resistant bacteria.



Tabib-Salazar, A., Liu, B., Doughty, P., Lewis, R.A., Ghosh, S., Parsy, M.L., Simpson, P.J., O'Dwyer, K., Matthews, S.J., & Paget, M.S., (2013). The actinobacterial transcription factor RbpA binds to the principal sigma subunit of RNA polymerase. Nucleic Acids Res. 41:5679-5691.

Tabib-Salazar, A*., Hubin, E.A*., Humphrey, L.J., Flack, J.E., Olinares, P.D., Darst, S.A., Campbell, E.A., & Paget, M.S., (2015). Structural, functional, and genetic analyses of the actinobacterial transcription factor RbpA. Proc Natl Acad Sci USA 112(33):7171-6. (A.T-S. and E.A.H contributed equally to the work).






Tabib-Salazar A, Mulvenna N, Severinov K, et al., 2019, Xenogeneic regulation of the bacterial transcription machinery, Journal of Molecular Biology, Vol:431, ISSN:0022-2836, Pages:4078-4092

Tabib-Salazar A, Liu B, Declan B, et al., 2018, T7 phage factor required for managing RpoS in Escherichia coli, Proceedings of the National Academy of Sciences, Vol:115, ISSN:0027-8424, Pages:E5353-E5362

Tabib-Salazar A, Liu B, Shadrin A, et al., 2017, Full shut-off of Escherichia coli RNA-polymerase by T7 phage requires a small phage-encoded DNA-binding protein, Nucleic Acids Research, Vol:45, ISSN:1362-4962, Pages:7697-7707

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