Aline obtained her undergraduate degree in Molecular Medicine at the University of Sussex in 2008. She then completed her PhD in 2012 studying RbpA, RNA polymerase binding protein, a transcriptional activator in S. coelicolor in Dr. Mark Paget's group at the Department of Biochemistry at the University of Sussex.
She is currently a research associate in the Wigneshweraraj group at the MRC Centre for Bacteriology & Infection. Her research is based on understanding the mechanisms by which phage-encoded small proteins inhibit the bacterial RNA polymerase. This study is aimed at developing new lead antibacterial compounds to target antibiotic resistant bacteria.
Tabib-Salazar, A., Liu, B., Doughty, P., Lewis, R.A., Ghosh, S., Parsy, M.L., Simpson, P.J., O'Dwyer, K., Matthews, S.J., & Paget, M.S., (2013). The actinobacterial transcription factor RbpA binds to the principal sigma subunit of RNA polymerase. Nucleic Acids Res. 41:5679-5691.
Tabib-Salazar, A*., Hubin, E.A*., Humphrey, L.J., Flack, J.E., Olinares, P.D., Darst, S.A., Campbell, E.A., & Paget, M.S., (2015). Structural, functional, and genetic analyses of the actinobacterial transcription factor RbpA. Proc Natl Acad Sci USA 112(33):7171-6. (A.T-S. and E.A.H contributed equally to the work).
et al., 2019, Xenogeneic regulation of the bacterial transcription machinery, Journal of Molecular Biology, Vol:431, ISSN:0022-2836, Pages:4078-4092
et al., 2018, T7 phage factor required for managing RpoS in Escherichia coli, Proceedings of the National Academy of Sciences, Vol:115, ISSN:0027-8424, Pages:E5353-E5362
et al., 2017, Full shut-off of Escherichia coli RNA-polymerase by T7 phage requires a small phage-encoded DNA-binding protein, Nucleic Acids Research, Vol:45, ISSN:1362-4962, Pages:7697-7707