Imperial College London

Dr Alejandra Tomas

Faculty of MedicineDepartment of Metabolism, Digestion and Reproduction

Non-Clinical Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3364a.tomas-catala Website CV

 
 
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Location

 

329ICTEM buildingHammersmith Campus

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Summary

 

Summary

Dr Alejandra Tomas obtained her PhD in Biochemistry at UCL in 2003, where she worked on the elucidation of the cellular roles of the calcium- and membrane-binding family of annexin proteins.

She then took up a postdoctoral position at the University of Geneva Medical School, Switzerland, where she analysed diverse aspects of the regulation of insulin secretion in pancreatic beta cells, primarily related to the role of the cytoskeleton in insulin exocytosis and the relationship between the secretory and endocytic pathways.

In 2009 she joined the Department of Biochemistry at University of Geneva where she focused on the study of receptor trafficking along the endocytic pathway, an area of research she continued to develop at UCL following her move back to the UK in 2011.

In 2015, Alejandra was awarded a New Investigator Research Grant by the MRC to set up an independent research group within the Section of Cell Biology and Functional Genomics to study the role of membrane receptor trafficking in the modulation of signalling and function of pancreatic beta cells.

Her laboratory is pursuing a number of investigations based on the study of the spatiotemporal regulation of signalling of the GLP-1 receptor and other key receptors involved in the control of blood glucose levels and related metabolic parameters.

Selected Publications

Journal Articles

Fremaux J, Venin C, Mauran L, et al., 2019, Ureidopeptide GLP-1 analogues with prolonged activity in vivo via signal bias and altered receptor trafficking, Chemical Science, Vol:42, ISSN:2041-6520, Pages:9872-9879

Tomas A, Jones B, Leech C, 2019, New insights into beta cell GLP-1 receptor and cAMP signaling., Journal of Molecular Biology, ISSN:0022-2836

Buenaventura T, Bitsi S, Laughlin WE, et al., 2019, Agonist-induced membrane nanodomain clustering drives GLP-1 receptor responses in pancreatic beta cells., PLOS Biology, Vol:17, ISSN:1544-9173, Pages:1-40

Jones B, Buenaventura T, Kanda N, et al., 2018, Targeting GLP-1 receptor trafficking to improve agonist efficacy, Nature Communications, Vol:9, ISSN:2041-1723

Jones B, Bloom S, Buenaventura T, et al., 2018, Control of insulin secretion by GLP-1, Peptides, Vol:100, ISSN:0196-9781, Pages:75-84

Podewin T, Ast J, Broichhagen J, et al., 2018, Conditional and reversible activation of class A and B G protein-coupled receptors using tethered pharmacology, Acs Central Science, Vol:4, ISSN:2374-7943, Pages:166-179

Buenaventura T, Kanda N, Douzenis PC, et al., 2017, A targeted RNAi screen identifies endocytic trafficking factors that control GLP-1 receptor signaling in pancreatic beta cells, Diabetes, Vol:67, ISSN:0012-1797, Pages:385-399

Jones BJ, Scopelliti R, Tomas A, et al., 2017, Potent prearranged positive allosteric modulators of the glucagon-like peptide-1 receptor, Chemistryopen, Vol:6, ISSN:2191-1363, Pages:501-505

More Publications