Imperial College London
Portrait Picture

Dr Alejandra Tomas

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Senior Lecturer
 
 
 
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Contact

 

+44 (0)20 7594 3364a.tomas-catala Website CV

 
 
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Location

 

329ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@inbook{Davies:2023:10.1016/bs.pmbts.2022.06.013,
author = {Davies, A and Tomas, A},
doi = {10.1016/bs.pmbts.2022.06.013},
pages = {101--120},
title = {Appreciating the potential for GPCR crosstalk with ion channels.},
url = {http://dx.doi.org/10.1016/bs.pmbts.2022.06.013},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - CHAP
AB  - G protein-coupled receptors (GPCRs) are expressed by most tissues in the body and are exploited pharmacologically in a variety of pathological conditions including diabetes, cardiovascular disease, neurological diseases, and cancers. Numerous cell signaling pathways can be regulated by GPCR activation, depending on the specific GPCR, ligand and cell type. Ion channels are among the many effector proteins downstream of these signaling pathways. Saliently, ion channels are also recognized as druggable targets, and there is evidence that their activity may regulate GPCR function via membrane potential and cytoplasmic ion concentration. Overall, there appears to be a large potential for crosstalk between ion channels and GPCRs. This might have implications not only for targeting GPCRs for drug development, but also opens the possibility of co-targeting them with ion channels to achieve improved therapeutic outcomes. In this review, we highlight the large variety of possible GPCR-ion channel crosstalk modes.
AU  - Davies,A
AU  - Tomas,A
DO  - 10.1016/bs.pmbts.2022.06.013
EP  - 120
PY  - 2023///
SP  - 101
TI  - Appreciating the potential for GPCR crosstalk with ion channels.
UR  - http://dx.doi.org/10.1016/bs.pmbts.2022.06.013
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36707150
ER  -
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