Imperial College London
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Dr Ashwin Venkataraman

Faculty of Medicine, Department of Brain Sciences

Clinical Research Fellow
 
 
 
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Contact

 

a.venkataraman

 
 
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Location

 

Burlington DanesHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Venkataraman:2016:alcalc/agw101,
author = {Venkataraman, A and Kalk, N and Sewell, G and W, Ritchie C and Lingford-Hughes, A and Venkataraman, A and Kalk, N and Sewell, G and Ritchie, C and Lingford-Hughes, A},
doi = {alcalc/agw101},
journal = {Alcohol and Alcoholism},
pages = {151--158},
title = {Alcohol and Alzheimer's Disease-Does Alcohol Dependence Contribute to Beta-Amyloid Deposition, Neuroinflammation and Neurodegeneration in Alzheimer's Disease?},
url = {http://dx.doi.org/10.1093/alcalc/agw101},
volume = {52},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Aims:To investigate the underlying neurobiology between alcohol use, misuse and dependence and cognitive impairment, particularly Alzheimer's disease (AD).Methods:Review of the literature using searches of Medline, Pubmed, EMBASE, PsycInfo, and meeting abstracts and presentations.Results:The role of alcohol as a risk factor and contributor for cognitive decline associated with AD has received little attention. This is despite the high prevalence of alcohol use, the potential reversibility of a degree of cognitive impairment and the global burden of AD. Until now the focus has largely been on the toxic effects of alcohol, neuronal loss and the role of thiamine.Conclusion:We propose alcohol adds to the cognitive burden seen in dementia through additional mechanisms to neurodegenerative processes or may contribute at various mechanistic points in the genesis and sustenance of AD pathology via neuroinflammation. We describe the common underlying neurobiology in alcohol and AD, and examine ways alcohol likely contributes to neuroinflammation directly via stimulation of Toll-like receptors and indirectly from small bowel changes, hepatic changes, withdrawal and traumatic brain injury to the pathogenesis of AD.
AU  - Venkataraman,A
AU  - Kalk,N
AU  - Sewell,G
AU  - W,Ritchie C
AU  - Lingford-Hughes,A
AU  - Venkataraman,A
AU  - Kalk,N
AU  - Sewell,G
AU  - Ritchie,C
AU  - Lingford-Hughes,A
DO  - alcalc/agw101
EP  - 158
PY  - 2016///
SN  - 1464-3502
SP  - 151
TI  - Alcohol and Alzheimer's Disease-Does Alcohol Dependence Contribute to Beta-Amyloid Deposition, Neuroinflammation and Neurodegeneration in Alzheimer's Disease?
T2  - Alcohol and Alcoholism
UR  - http://dx.doi.org/10.1093/alcalc/agw101
UR  - http://www.ncbi.nlm.nih.gov/pubmed/28182204
UR  - http://hdl.handle.net/10044/1/42603
VL  - 52
ER  -
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