Publications
565 results found
Fingerlin TE, Murphy E, Zhang W, et al., 2013, Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis, Nature Genetics, Vol: 45, Pages: 613-624, ISSN: 1061-4036
We performed a genome-wide association study of non-Hispanic, white individuals with fibrotic idiopathic interstitial pneumonias (IIPs; n = 1,616) and controls (n = 4,683), with follow-up replication analyses in 876 cases and 1,890 controls. We confirmed association with TERT at 5p15, MUC5B at 11p15 and the 3q26 region near TERC, and we identified seven newly associated loci (Pmeta = 2.4 × 10−8 to 1.1 × 10−19), including FAM13A (4q22), DSP (6p24), OBFC1 (10q24), ATP11A (13q34), DPP9 (19p13) and chromosomal regions 7q22 and 15q14-15. Our results suggest that genes involved in host defense, cell-cell adhesion and DNA repair contribute to risk of fibrotic IIPs.
Raghu G, Behr J, Brown KK, et al., 2013, Treatment of Idiopathic Pulmonary Fibrosis With Ambrisentan A Parallel, Randomized Trial, ANNALS OF INTERNAL MEDICINE, Vol: 158, Pages: 641-+, ISSN: 0003-4819
- Author Web Link
- Cite
- Citations: 347
Wuyts WA, Agostini C, Antoniou KM, et al., 2013, The pathogenesis of pulmonary fibrosis: a moving target, EUROPEAN RESPIRATORY JOURNAL, Vol: 41, Pages: 1207-1218, ISSN: 0903-1936
- Author Web Link
- Cite
- Citations: 210
Stock CJ, Sato H, Fonseca C, et al., 2013, Mucin 5B promoter polymorphism is associated with idiopathic pulmonary fibrosis but not with development of lung fibrosis in systemic sclerosis or sarcoidosis, THORAX, Vol: 68, Pages: 436-441, ISSN: 0040-6376
- Author Web Link
- Cite
- Citations: 159
Wells AU, 2013, The revised ATS/ERS/JRS/ALAT diagnostic criteria for idiopathic pulmonary fibrosis (IPF) - practical implications, RESPIRATORY RESEARCH, Vol: 14
- Author Web Link
- Cite
- Citations: 59
Wells AU, Kelleher WP, 2013, Idiopathic Pulmonary Fibrosis Pathogenesis and Novel Approaches to Immunomodulation We Must Not Be Tyrannized by the PANTHER Data, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 187, Pages: 677-679, ISSN: 1073-449X
- Author Web Link
- Cite
- Citations: 7
Wells AU, Kelleher WP, 2013, Idiopathic pulmonary fibrosis pathogenesis and novel approaches to immunomodulation: we must not be tyrannized by the PANTHER data., Am J Respir Crit Care Med, Vol: 187, Pages: 677-679
De Lauretis A, Sestini P, Pantelidis P, et al., 2013, Serum Interleukin 6 Is Predictive of Early Functional Decline and Mortality in Interstitial Lung Disease Associated with Systemic Sclerosis, JOURNAL OF RHEUMATOLOGY, Vol: 40, Pages: 435-446, ISSN: 0315-162X
- Author Web Link
- Cite
- Citations: 180
Lota HK, Dusmet M, Steele K, et al., 2013, A rapidly growing lung mass with air crescent formation, THORAX, Vol: 68, Pages: 394-395, ISSN: 0040-6376
- Author Web Link
- Cite
- Citations: 2
Wells AU, 2013, Forced vital capacity as a primary end point in idiopathic pulmonary fibrosis treatment trials: making a silk purse from a sow's ear, THORAX, Vol: 68, Pages: 309-310, ISSN: 0040-6376
- Author Web Link
- Cite
- Citations: 45
Bajwah S, Koffman J, Higginson IJ, et al., 2013, 'I wish I knew more ...' the end-of-life planning and information needs for end-stage fibrotic interstitial lung disease: views of patients, carers and health professionals., BMJ Support Palliat Care, Vol: 3, Pages: 84-90
The importance at the end of life of developing effective communication and meeting information needs is recognised as being central to enhance patient and family centred experience. This qualitative study aimed to explore understanding of the disease, preferences regarding end-of-life planning, and views on communication and coordination of care in patients with Progressive Idiopathic Fibrotic Interstitial Lung Disease (PIF-ILD). Twelve semistructured in-depth qualitative interviews were conducted among PIF-ILD patients and carers attending two London hospitals. Six Interviews were also conducted among health professionals from one London Hospital, a palliative care service and primary care. There was good understanding of the terminal nature of the disease among both patients and carers, but a poor understanding of prognosis, and how the disease would manifest at the end stages. Both patients and carers expressed a wish to receive more information from clinicians. Health professionals recognised the difficulty of balancing information needs with maintaining hope. No participants were aware of any palliative care input, and no participants had considered important end-of-life issues, such as preferred place of care and preferred place of death. Our work shows that palliative interventions need to be developed for this group of patients which should aim to improve communication and coordination of care, while facilitating discussions surrounding information needs and important end-of-life preferences.
Stock C, Sato H, Fonseca C, et al., 2013, <i>IRF5</i> POLYMORPHISMS IN SYSTEMIC SCLEROSIS, 33rd European Workshop for Rheumatology Research (EWRR), Publisher: BMJ PUBLISHING GROUP, Pages: A52-A53, ISSN: 0003-4967
- Author Web Link
- Cite
- Citations: 1
Hopkinson NS, Moxham J, Montgomery H, et al., 2013, Tobacco industry lobbyists and their health-care clients, LANCET, Vol: 381, Pages: 445-445, ISSN: 0140-6736
- Author Web Link
- Cite
- Citations: 3
Rapti A, Kouranos V, Gialafos E, et al., 2013, Elevated Pulmonary Arterial Systolic Pressure in Patients with Sarcoidosis: Prevalence and Risk Factors, LUNG, Vol: 191, Pages: 61-67, ISSN: 0341-2040
- Author Web Link
- Cite
- Citations: 24
Lota HK, Wells AU, 2013, The evolving pharmacotherapy of pulmonary fibrosis, EXPERT OPINION ON PHARMACOTHERAPY, Vol: 14, Pages: 79-89, ISSN: 1465-6566
- Author Web Link
- Cite
- Citations: 21
Antoniou KM, Wells AU, 2013, Acute Exacerbations of Idiopathic Pulmonary Fibrosis, RESPIRATION, Vol: 86, Pages: 265-274, ISSN: 0025-7931
- Author Web Link
- Cite
- Citations: 36
Coleman MC, Bastin AJ, Renzoni EA, et al., 2012, INTENSIVE CARE UNIT ADMISSION SHOULD PLAY A ROLE IN THE MANAGEMENT OF SELECTED PATIENTS WITH INTERSTITIAL LUNG DISEASE, Winter Meeting of the British-Thoracic-Society 2012, Publisher: BMJ PUBLISHING GROUP, Pages: A50-A50, ISSN: 0040-6376
Bajwah S, Ross JR, Peacock JL, et al., 2012, WHAT IS THE EVIDENCE FOR PHARMACOLOGICAL AND NON-PHARMACOLOGICAL INTERVENTIONS IN IMPROVING DYSPNOEA, OTHER SYMPTOMS AND QUALITY OF LIFE IN PROGRESSIVE IDIOPATHIC FIBROTIC INTERSTITIAL LUNG DISEASE?- A SYSTEMATIC REVIEW OF THE LITERATURE, Winter Meeting of the British-Thoracic-Society 2012, Publisher: BMJ PUBLISHING GROUP, Pages: A118-A119, ISSN: 0040-6376
Wells AU, Behr J, Costabel U, et al., 2012, Hot off the breath: Mortality as a primary end-point in IPF treatment trials: the best is the enemy of the good, THORAX, Vol: 67, Pages: 938-U12, ISSN: 0040-6376
- Author Web Link
- Cite
- Citations: 62
Copley SJ, Giannarou S, Schmid VJ, et al., 2012, Effect of Aging on Lung Structure In Vivo: Assessment With Densitometric and Fractal Analysis of High-resolution Computed Tomography Data, JOURNAL OF THORACIC IMAGING, Vol: 27, Pages: 366-371, ISSN: 0883-5993
- Author Web Link
- Cite
- Citations: 32
Betteridge Z, Woodhead F, Bunn C, et al., 2012, Anti-EIF2B: A Novel Interstitial Lung Disease Associated Autoantibody in Patients with Systemic Sclerosis, Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP), Publisher: WILEY-BLACKWELL, Pages: S373-S373, ISSN: 0004-3591
- Author Web Link
- Cite
- Citations: 1
Saketkoo LA, Huscher D, Khanna D, et al., 2012, Developing an Index for Disease Activity and Therapeutic Response in Connective Tissue Disease Related Interstitial Lung Disease: Results From A Delphi Exercise: Delivering A Consensus On Domains., Annual Scientific Meeting of the American-College-of-Rheumatology (ACR) and Association-of-Rheumatology-Health-Professionals (ARHP), Publisher: WILEY-BLACKWELL, Pages: S734-S734, ISSN: 0004-3591
- Author Web Link
- Cite
- Citations: 1
Aston K, Riddell GJ, Sheppard MN, et al., 2012, Pulmonary capillary haemangiomatosis - An unusual cause of hypoxia., Respiratory Medicine Case Reports, Vol: 7, Pages: 12-14, ISSN: 2213-0071
We describe the case of a 58-year-old man who presented with progressive dyspnoea on exertion and severe exertional hypoxia. There was a paucity of radiological findings, mild pulmonary hypertension, and no demonstrable anatomical shunt. Post mortem examination of lung tissue suggested a diagnosis of pulmonary capillary haemangiomatosis. The case is unusual in displaying few radiological findings. We postulate that the severe hypoxia was due to shunting through the abnormal capillary proliferations.
Keir GJ, Maher TM, Hansell DM, et al., 2012, Severe interstitial lung disease in connective tissue disease: rituximab as rescue therapy, EUROPEAN RESPIRATORY JOURNAL, Vol: 40, Pages: 641-648, ISSN: 0903-1936
- Author Web Link
- Cite
- Citations: 98
Patel AS, Siegert RJ, Brignall K, et al., 2012, The development and validation of the King's Brief Interstitial Lung Disease (K-BILD) health status questionnaire, THORAX, Vol: 67, Pages: 804-810, ISSN: 0040-6376
- Author Web Link
- Cite
- Citations: 152
Wilson R, Wells AU, 2012, Azithromycin in bronchiectasis: when should it be used?, LANCET, Vol: 380, Pages: 627-629, ISSN: 0140-6736
- Author Web Link
- Cite
- Citations: 10
Reddy TL, Tominaga M, Hansell DM, et al., 2012, Pleuroparenchymal fibroelastosis: a spectrum of histopathological and imaging phenotypes, EUROPEAN RESPIRATORY JOURNAL, Vol: 40, Pages: 377-385, ISSN: 0903-1936
- Author Web Link
- Cite
- Citations: 244
Walsh SLF, Sverzellati N, Devaraj A, et al., 2012, Chronic hypersensitivity pneumonitis: high resolution computed tomography patterns and pulmonary function indices as prognostic determinants, EUROPEAN RADIOLOGY, Vol: 22, Pages: 1672-1679, ISSN: 0938-7994
- Author Web Link
- Cite
- Citations: 134
Ferrand RA, Desai SR, Hopkins C, et al., 2012, Chronic Lung Disease in Adolescents With Delayed Diagnosis of Vertically Acquired HIV Infection, CLINICAL INFECTIOUS DISEASES, Vol: 55, Pages: 145-152, ISSN: 1058-4838
- Author Web Link
- Cite
- Citations: 76
Mueller-Quernheim J, Wells A, 2012, Evidence-based Recommendations in Idiopathic Pulmonary Fibrosis A Year Is a Long Time in Interstitial Lung Disease, AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE, Vol: 186, Pages: 5-7, ISSN: 1073-449X
- Author Web Link
- Cite
- Citations: 4
This data is extracted from the Web of Science and reproduced under a licence from Thomson Reuters. You may not copy or re-distribute this data in whole or in part without the written consent of the Science business of Thomson Reuters.