The POPPY Study
A prospective, observational study to examine the effects of ageing on the clinical outcomes of people living with HIV in England and Ireland.
- To analyse the incidence and outcomes of intercurrent illness in older-HIV-positive people and their relationship with demographic/clinical factors.
- To evaluate associations between antiretroviral drug concentrations and age, and to assess the potential impact of age on drug efficacy, drug-drug interactions and other illness.
- To contribute to the development and implementation of evidence-based recommendations for the clinical monitoring of older HIV-positive patients.
The COBRA Study
Persons with HIV on combination antiretroviral therapy (cART) are at increased risk of the premature development of age-associated non-communicable comorbidities (AANCC). It has therefore been hypothesised that such individuals, despite effective cART, may be prone to accelerated ageing. By building on an established infrastructure for conducting longitudinal HIV cohort studies in Amsterdam and London, the COBRA project provide a detailed, prospective evaluation of AANCC among HIV-infected patientssuppressed on cART and appropriately chosen and comparible non-infected controls. The successful execution of the experimental and clinical research outlined in this study will be ensured through a strong interdisciplinary collaboration between clinical, basic and translational scientists bridging the fields of HIV, AANCC and ageing.
‘CNS toxicity of antiretroviral drugs’, 3rd North European Workshop on HIV-infection in the CNS (HANSA 2013), Hamburg, Germany, 2013
The pathology of HIV Associated Neurocognitive Disorders, 24th European Congress for the Society of Pathology, Prague, Czech Republic, 2012
Asymptomatic Neurocognitive Impairment: Illusion or Reality?, 5th International Symposium on Neuropsychiatry and HIV, Barcelona, Spain, 2012
Growing up with HIV – the story from birth till adolescence‘Monitoring brain function and metabolic syndrome in adults with HIV’, The Royal Society of Medicine, London, UK, 2012
Methodological Approaches to Assess Brain Function and Infection in Clinical Trials of ARV drugs, IV International Meeting on HIV Infection and the CNS, Frascati, Italy, 2011