157 results found
Zhang Y, Jiang N, Yetisen AK, 2021, Brain neurochemical monitoring, BIOSENSORS & BIOELECTRONICS, Vol: 189, ISSN: 0956-5663
Pazos MD, Hu Y, Elani Y, et al., 2021, Tattoo inks for optical biosensing in interstitial fluid, Advanced Healthcare Materials, ISSN: 2192-2640
The persistence of traditional tattoo inks presents an advantage for continuous andlong-term health monitoring in point of care devices. The replacement of tattoo pigments withoptical biosensors aims a promising alternative for monitoring blood biomarkers. Tattoo inksfunctionalization enables the control of interstitial biomarkers with correlated concentrations inplasma, to diagnose diseases, evaluate progression, and prevent complications associated withphysio pathological disorders or medication mismatches. The specific biomarkers in interstitialfluid provide a new source of information, especially for skin diseases. The study of tattoo inksdisplays insufficient regulation in their composition, a lack of reports of the relatedcomplications and a need for further studies on their degradation kinetics. This review focuseson tattoo optical biosensors for monitoring dermal interstitial biomarkers and discusses theyclinical advantages and main challenges for in vivo implantation. Tattoo functionalizationprovides a minimally invasive, reversible, biocompatible, real-time sensing with long-termpermanence and multiplexing capabilities for the control, diagnosis, and prevention of illness;it enables self-controlling management by the patient, but also the possibility of sending therecords to the doctor.
Jiang N, Flyax S, Kurz W, et al., 2021, Intracranial Sensors for Continuous Monitoring of Neurophysiology, ADVANCED MATERIALS TECHNOLOGIES, ISSN: 2365-709X
Moreddu R, Nasrollahi V, Kassanos P, et al., 2021, Lab-on-a-Contact Lens Platforms Fabricated by Multi-Axis Femtosecond Laser Ablation, SMALL, ISSN: 1613-6810
Dong X, Yetisen AK, Dong J, et al., 2021, Hyperspectral Fingerprints for Atomic Layer Mapping of Two-Dimensional Materials with Single-Layer Accuracy, JOURNAL OF PHYSICAL CHEMISTRY C, Vol: 125, Pages: 16583-16590, ISSN: 1932-7447
Alseed MM, Syed H, Onbasli MC, et al., 2021, Design and Adoption of Low-Cost Point-of-Care Diagnostic Devices: Syrian Case, MICROMACHINES, Vol: 12
Balbach S, Jiang N, Moreddu R, et al., 2021, Smartphone-Based Colorimetric Detection System for Portable Health Tracking, Analytical Methods
Davies S, Hu Y, Jiang N, et al., 2021, Holographic sensors in biotechnology, Advanced Functional Materials, ISSN: 1616-301X
As populations expand worldwide, medical care will need to diversify its data collection techniques to be able to provide adequate healthcare to global populations, this could be achieved through point-of-care analysis by wearable analytical devices. Holographic sensors are reusable optical biosensors with the capability to continuously monitor variations, generating the prospect of in vivo monitoring of patient homeostasis. Holographic optical sensors have emerged as an opportunity for low cost and real-time point-of-care analysis of biomarkers to be realised. This review aims to summarise the fundamentals and fabrications of holographic sensors; a key focus will be directed to examining the biotechnology applications in a variety of analytical settings. Techniques covered include surface relief gratings, inverse opals, metal nanoparticle and nanoparticle free holographic sensors. This article provides an overview of holographic biosensing in applications such as pH, alcohol, ion, glucose, and drug detection, alongside antibiotic monitoring. Details of developments in fabrication and sensitising techniques will be examined and how they have improved the applicability of holographic sensors to point-of-care analytics. Although holographic sensors have made significant progress in recent years, the current challenges, and requirements for advanced holographic technology to fulfil their future potential applications in biomedical devices will be discussed.
Montelongo A, Becker JL, Roman R, et al., 2021, The management of COVID-19 cases through telemedicine in Brazil, PLoS One, Vol: 16, Pages: 1-14, ISSN: 1932-6203
In Dec 2020 Brazil became one of the worldwide epicenters of the COVID-19 pandemic with more than 7.2M reported cases. Brazil has a large territory with unequal distribution of healthcare resources including physicians. Resource limitation has been one of the main factors hampering Brazil’s response to the COVID-19 crisis. Telemedicine has been an effective approach for COVID-19 management as it allows to reduce the risk of cross-contamination and provides support to remote rural locations. Here we present the analyses of teleconsultations from a countrywide telemedicine service (TelessáudeRS-UFRGS, TRS), that provides physician-to-physician remote support during the COVID-19 pandemic in Brazil. We performed a descriptive analysis of the teleconsultation incoming calls and a text analysis from the call transcripts. Our findings indicate that TRS teleconsultations in Brazil experienced an exponential increment of 802.% during a period of 6 days, after the first death due to COVID-19 was reported. However, the number of teleconsultations cases decreased over time, despite the number of reported COVID-19 cases continuously increasing. The results also showed that physicians in low-income municipalities, based on GDP per capita, are less likely to consult the telemedicine service despite facing higher rates of COVID-19 cases. The text analysis of call transcripts from medical teleconsultations showed that the main concern of physicians were “asymptomatic” patients. We suggest an immediate reinforcement of telehealth services in the regions of lower income as a strategy to support COVID-19 management.
Advances in multifunctional materials and technologies have allowed contact lenses to serve as wearable devices for continuous monitoring of physiological parameters and delivering drugs for ocular diseases. Since the tear fluids comprise a library of biomarkers, direct measurement of different parameters such as concentration of glucose, urea, proteins, nitrite, and chloride ions, intraocular pressure (IOP), corneal temperature, and pH can be carried out non-invasively using contact lens sensors. Microfluidic contact lens sensor based colorimetric sensing and liquid control mechanisms enable the wearers to perform self-examinations at home using smartphones. Furthermore, drug-laden contact lenses have emerged as delivery platforms using a low dosage of drugs with extended residence time and increased ocular bioavailability. This review provides an overview of contact lenses for ocular diagnostics and drug delivery applications. The designs, working principles, and sensing mechanisms of sensors and drug delivery systems are reviewed. The potential applications of contact lenses in point-of-care diagnostics and personalized medicine, along with the significance of integrating multiplexed sensing units together with drug delivery systems, have also been discussed.
Jiang N, Tansukawat ND, Gonzalez-Macia L, et al., 2021, Low-Cost Optical Assays for Point-of-Care Diagnosis in Resource-Limited Settings, ACS SENSORS, Vol: 6, Pages: 2108-2124, ISSN: 2379-3694
Liu Q, Tian J, Tian Y, et al., 2021, Thiophene donor for NIR-II fluorescence imaging-guided photothermal/photodynamic/chemo combination therapy, ACTA BIOMATERIALIA, Vol: 127, Pages: 287-297, ISSN: 1742-7061
Sarabi MR, Ahmadpour A, Yetisen AK, et al., 2021, Finger-Actuated Microneedle Array for Sampling Body Fluids, APPLIED SCIENCES-BASEL, Vol: 11
Yin Y, Wang W, Shao Q, et al., 2021, Pentapeptide IKVAV-engineered hydrogels for neural stem cell attachment, BIOMATERIALS SCIENCE, Vol: 9, Pages: 2887-2892, ISSN: 2047-4830
Salih AE, Elsherif M, Alam F, et al., 2021, Gold nanocomposite contact Lenses for color blindness management, ACS Nano, Vol: 15, Pages: 4870-4880, ISSN: 1936-0851
Color vision deficiency (CVD) is an ocular congenital disorder that affects 8% of males and 0.5% of females. The most prevalent form of color vision deficiency (color blindness) affects protans and deutans and is more commonly known as “red–green color blindness”. Since there is no cure for this disorder, CVD patients opt for wearables that aid in enhancing their color perception. The most common wearable used by CVD patients is a form of tinted glass/lens. Those glasses filter out the problematic wavelengths (540–580 nm) for the red–green CVD patients using organic dyes. However, few studies have addressed the fabrication of contact lenses for color vision deficiency, and several problems related to their effectiveness and toxicity were reported. In this study, gold nanoparticles are integrated into contact lens material, thus forming nanocomposite contact lenses targeted for red–green CVD application. Three distinct sets of nanoparticles were characterized and incorporated with the hydrogel material of the lenses (pHEMA), and their resulting optical and material properties were assessed. The transmission spectra of the developed nanocomposite lenses were analogous to those of the commercial CVD wearables, and their water retention and wettability capabilities were superior to those in some of the commercially available contact lenses used for cosmetic/vision correction purposes. Hence, this work demonstrates the potential of gold nanocomposite lenses in CVD management and, more generally, color filtering applications.
AlQattan B, Doocey J, Ali M, et al., 2021, Direct printing of nanostructured holograms on consumable substrates, ACS Nano, Vol: 15, Pages: 2340-2349, ISSN: 1936-0851
Direct texturing of nanostructures on consumable substrates and products is a challenge because of incompatible ingredients and materials’ properties. Here, we developed a direct laser-based method to print nanostructured holograms on dried films of consumable corn syrup solutions. A holographic laser (λ = 1050 nm) interference system was used to construct the nanostructures of the holograms on food for rainbow effects. The relationship between wavelength and periodicity contributed to the changing diffraction angle through the change of the refractive index (1.642). Increasing the sugar concentration (25–175 mg) in the syrup increased the diffraction efficiency of these holograms. The added amount of sugar in the composition increased the refractive index (7%) and decreased the light absorption (12.9%), which influenced the change of diffraction angle by 4.4°. The surface holograms displayed wideband visual diffraction of light extending from violet to red wavelengths. These holograms on edible materials can be imprinted onto commercial food products for adding aesthetic value and controlling perception.
Dong X, Li H, Jiang Z, et al., 2021, 3D Deep Learning Enables Accurate Layer Mapping of 2D Materials, ACS NANO, Vol: 15, Pages: 3139-3151, ISSN: 1936-0851
Liu Q, Tian J, Tian Y, et al., 2021, Near-Infrared-II Nanoparticles for Cancer Imaging of Immune Checkpoint Programmed Death-Ligand 1 and Photodynamic/Immune Therapy, ACS NANO, Vol: 15, Pages: 515-525, ISSN: 1936-0851
Dabbagh SR, Sarabi MR, Rahbarghazi R, et al., 2021, 3D-printed microneedles in biomedical applications, ISCIENCE, Vol: 24
Dabbagh SR, Becher E, Ghaderinezhad F, et al., 2021, Increasing the packing density of assays in paper-based microfluidic devices., Biomicrofluidics, Vol: 15, ISSN: 1932-1058
Paper-based devices have a wide range of applications in point-of-care diagnostics, environmental analysis, and food monitoring. Paper-based devices can be deployed to resource-limited countries and remote settings in developed countries. Paper-based point-of-care devices can provide access to diagnostic assays without significant user training to perform the tests accurately and timely. The market penetration of paper-based assays requires decreased device fabrication costs, including larger packing density of assays (i.e., closely packed features) and minimization of assay reagents. In this review, we discuss fabrication methods that allow for increasing packing density and generating closely packed features in paper-based devices. To ensure that the paper-based device is low-cost, advanced fabrication methods have been developed for the mass production of closely packed assays. These emerging methods will enable minimizing the volume of required samples (e.g., liquid biopsies) and reagents in paper-based microfluidic devices.
Chen Y, Zhang S, Cui Q, et al., 2020, Microengineered poly(HEMA) hydrogels for wearable contact lens biosensing, LAB ON A CHIP, Vol: 20, Pages: 4205-4214, ISSN: 1473-0197
Moreddu R, Elsherif M, Adams H, et al., 2020, Integration of paper microfluidic sensors into contact lenses for tear fluid analysis, LAB ON A CHIP, Vol: 20, Pages: 3970-3979, ISSN: 1473-0197
Dabbagh SR, Rabbi F, Dogan Z, et al., 2020, Machine learning-enabled multiplexed microfluidic sensors, BIOMICROFLUIDICS, Vol: 14
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