144 results found
Liu Q, Tian J, Tian Y, et al., 2021, Thiophene donor for NIR-II fluorescence imaging-guided photothermal/photodynamic/chemo combination therapy., Acta Biomater
Organic fluorophores/photosensitizers have been widely used in biological imaging and photodynamic and photothermal combination therapy in the first near-infrared (NIR-I) window. However, their applications in the second near-infrared (NIR-II) window are still limited primarily due to low fluorescence quantum yields (QYs). Here, a boron dipyrromethene (BDP) is created as a molecularly engineered thiophene donor unit with high QYs to the redshift. Thiophene insertion initiates substantial redshifts of the absorbance as compared to its counterparts in which iodine is introduced. The fluorescent molecule can be triggered by an NIR laser with a single wavelength, thereby producing emission in the NIR-II windows. Single NIR laser-triggered phototherapeutic nanoparticles (NPs) are developed by encapsulating the BDP and the chemotherapeutic drug docetaxel (DTX) by using a synthetic amphiphilic poly(styrene-co-chloromethyl styrene)-graft-poly(ethylene glycol) functionalized with folic acid (FA). These BDP-T-N-DTX-FA NPs not only show superior solubility and high singlet oxygen QY (ΦΔ=62%) but also demonstrate single NIR laser-triggered multifunctional characteristics. After intravenous administration of the NPs into 4T1 tumor-bearing mice, the accumulation of the NPs in the tumor showed a high signal-to-background ratio (11.8). Furthermore, 4T1 tumors in mice were almost eradicated by DTX released from the BDP-T-N-DTX-FA NPs under single NIR laser excitation and the combination of photodynamic therapy (PDT) and photothermic therapy (PTT). STATEMENT OF SIGNIFICANCE: : The application of organic photosensitizers is still limited primarily due to low fluorescence quantum yields (QYs) in the second near-infrared (NIR-II) window. Here, a boron dipyrromethene (BDP) as a molecularly engineered thiophene donor unit with high QYs to the redshift is created. Phototherapeutic nanoparticles (NPs) are developed by encapsulating the BDP and docetaxel (DTX) using a synthetic amp
Holographic sensors are two-dimensional (2D) photonic crystals that diffract narrow-band light in the visible spectrum to quantify analytes in aqueous solutions. Here, a holographic fabrication setup was developed to produce holographic sensors through a doubly polymerization system of a poly-2-hydroxyethyl methacrylate hydrogel film using a pulsed Nd:YAG laser (λ = 355 nm, 5 ns, 100 mJ). Wavelength shifts of holographic Bragg peak in response to alcohol species (0-100 vol %) were characterized. Diffraction spectra showed that the holographic sensors could be used for short-chain alcohols at concentrations up to 60 vol %. The reversibility of the sensor was demonstrated, exhibiting a response time of 7.5 min for signal saturation. After 30 cycles, the Bragg peak and color remained the same in both 20 and 60 vol %. The fabrication parameters were simulated in MATLAB using a 2D finite-difference time-domain algorithm to model the interference pattern and energy flux profile of laser beam recording in the hydrogel medium. This work demonstrates a particle-free holographic sensor that offers continuous, reversible, and rapid colorimetric readouts for the real-time quantification of alcohols.
Salih AE, Elsherif M, Alam F, et al., 2021, Gold Nanocomposite Contact Lenses for Color Blindness Management., ACS Nano, Vol: 15, Pages: 4870-4880
Color vision deficiency (CVD) is an ocular congenital disorder that affects 8% of males and 0.5% of females. The most prevalent form of color vision deficiency (color blindness) affects protans and deutans and is more commonly known as "red-green color blindness". Since there is no cure for this disorder, CVD patients opt for wearables that aid in enhancing their color perception. The most common wearable used by CVD patients is a form of tinted glass/lens. Those glasses filter out the problematic wavelengths (540-580 nm) for the red-green CVD patients using organic dyes. However, few studies have addressed the fabrication of contact lenses for color vision deficiency, and several problems related to their effectiveness and toxicity were reported. In this study, gold nanoparticles are integrated into contact lens material, thus forming nanocomposite contact lenses targeted for red-green CVD application. Three distinct sets of nanoparticles were characterized and incorporated with the hydrogel material of the lenses (pHEMA), and their resulting optical and material properties were assessed. The transmission spectra of the developed nanocomposite lenses were analogous to those of the commercial CVD wearables, and their water retention and wettability capabilities were superior to those in some of the commercially available contact lenses used for cosmetic/vision correction purposes. Hence, this work demonstrates the potential of gold nanocomposite lenses in CVD management and, more generally, color filtering applications.
A wide range of platforms has been developed for 3D culture of cells in vitro to aggregate and align cells to resemble in vivo conditions in order to enhance communication between cells and promote differentiation. The cellulose skeleton of plant tissue can serve as an attainable scaffold for mammalian cells after decellularization, which is advantageous when compared to synthetic polymers or animal-derived scaffolds. Adjustable variables to modify the physical and biochemical properties of the resulting scaffolds include the protocol for the sodium dodecyl sulfate (SDS)-based decellularization procedure, surface coatings for cell attachment, plant type for decellularization, differentiation media, and integrity and shape of the substrate. These tunable cellulose platforms can host a wide range of mammalian cell types from muscle to bone cells, as well as malignancies. Here, fundamentals and applications of decellularized plant-based scaffolds are discussed. These biocompatible, naturally perfused, tunable, and easily prepared decellularized scaffolds may allow eco-friendly manufacturing frameworks for application in tissue engineering and organs-on-a-chip.
Dong X, Li H, Jiang Z, et al., 2021, 3D Deep Learning Enables Accurate Layer Mapping of 2D Materials, ACS NANO, Vol: 15, Pages: 3139-3151, ISSN: 1936-0851
AlQattan B, Doocey J, Ali M, et al., 2021, Direct Printing of Nanostructured Holograms on Consumable Substrates, ACS NANO, Vol: 15, Pages: 2340-2349, ISSN: 1936-0851
Yin Y, Wang W, Shao Q, et al., 2021, Pentapeptide IKVAV-engineered hydrogels for neural stem cell attachment., Biomater Sci
Spinal cord injury remains irreversible with current treatment paradigms, due to the inability to rebuild the regenerative environment for neurons after injury. Neural tissue engineering that encapsulates the neural stem/progenitor cells within an artificial scaffold provides a possibility to regenerate neurons for spinal cord injury repair. The attachment and survival of these neural cells usually require similar microenvironments to the extracellular matrix for support. Here, a three-dimensional pentapeptide IKVAV-functionalized poly(lactide ethylene oxide fumarate) (PLEOF) hydrogel is developed. In vitro tests demonstrate that the IKVAV-PLEOF hydrogels are biodegradable and hemo-biocompatible. This IKVAV-PLEOF hydrogel is shown to support neural stem cell attachment, growth, proliferation, and differentiation. Additionally, the neural stem cells could be readily formed as spheroids that subsequently encapsulated, attached, and proliferated within the three-dimensional hydrogel constructs. Additionally, an in vivo test confirms the biodegradability and biocompatibility of the IKVAV-PLEOF hydrogels revealing that the hydrogels biodegrade, new blood vessels form, and few inflammatory responses are observed after 4-week implantation. The neural stem cell spheroid-laden hydrogels may have further implications in spinal cord injury regenerative and brain repair in neural tissue engineering.
Liu Q, Tian J, Tian Y, et al., 2021, Near-Infrared-II Nanoparticles for Cancer Imaging of Immune Checkpoint Programmed Death-Ligand 1 and Photodynamic/Immune Therapy, ACS NANO, Vol: 15, Pages: 515-525, ISSN: 1936-0851
Dabbagh SR, Sarabi MR, Rahbarghazi R, et al., 2021, 3D-printed microneedles in biomedical applications, ISCIENCE, Vol: 24
Dabbagh SR, Becher E, Ghaderinezhad F, et al., 2021, Increasing the packing density of assays in paper-based microfluidic devices., Biomicrofluidics, Vol: 15, ISSN: 1932-1058
Paper-based devices have a wide range of applications in point-of-care diagnostics, environmental analysis, and food monitoring. Paper-based devices can be deployed to resource-limited countries and remote settings in developed countries. Paper-based point-of-care devices can provide access to diagnostic assays without significant user training to perform the tests accurately and timely. The market penetration of paper-based assays requires decreased device fabrication costs, including larger packing density of assays (i.e., closely packed features) and minimization of assay reagents. In this review, we discuss fabrication methods that allow for increasing packing density and generating closely packed features in paper-based devices. To ensure that the paper-based device is low-cost, advanced fabrication methods have been developed for the mass production of closely packed assays. These emerging methods will enable minimizing the volume of required samples (e.g., liquid biopsies) and reagents in paper-based microfluidic devices.
Chen Y, Zhang S, Cui Q, et al., 2020, Microengineered poly(HEMA) hydrogels for wearable contact lens biosensing, LAB ON A CHIP, Vol: 20, Pages: 4205-4214, ISSN: 1473-0197
Moreddu R, Elsherif M, Adams H, et al., 2020, Integration of paper microfluidic sensors into contact lenses for tear fluid analysis, LAB ON A CHIP, Vol: 20, Pages: 3970-3979, ISSN: 1473-0197
Dabbagh SR, Rabbi F, Dogan Z, et al., 2020, Machine learning-enabled multiplexed microfluidic sensors, BIOMICROFLUIDICS, Vol: 14
Akram MS, Pery N, Butler L, et al., 2020, Challenges for biosimilars: focus on rheumatoid arthritis, CRITICAL REVIEWS IN BIOTECHNOLOGY, Vol: 41, Pages: 121-153, ISSN: 0738-8551
Alam F, Elsherif M, AlQattan B, et al., 2020, Prospects for Additive Manufacturing in Contact Lens Devices, ADVANCED ENGINEERING MATERIALS, Vol: 23, ISSN: 1438-1656
Jiang N, Yetisen AK, Linhart N, et al., 2020, Fluorescent dermal tattoo biosensors for electrolyte analysis, SENSORS AND ACTUATORS B-CHEMICAL, Vol: 320
Dong J, Yetisen AK, Dong X, et al., 2020, Low-pass filtering compensation in common-path digital holographic microscopy, APPLIED PHYSICS LETTERS, Vol: 117, ISSN: 0003-6951
Vasquez ESL, Yetisen AK, Vega K, 2020, BraceIO, UbiComp/ISWC '20: 2020 ACM International Joint Conference on Pervasive and Ubiquitous Computing and 2020 ACM International Symposium on Wearable Computers, Publisher: ACM
Moreddu R, Wolffsohn JS, Vigolo D, et al., 2020, Laser-inscribed contact lens sensors for the detection of analytes in the tear fluid, SENSORS AND ACTUATORS B-CHEMICAL, Vol: 317
Ali M, Elsherif M, Salih AE, et al., 2020, Surface modification and cytotoxicity of Mg-based bio-alloys: An overview of recent advances, JOURNAL OF ALLOYS AND COMPOUNDS, Vol: 825, ISSN: 0925-8388
Hendi A, Hassan MU, Elsherif M, et al., 2020, Healthcare applications of pH-sensitive hydrogels based devices: a review, International Journal of Nanomedicine, Vol: 2020, Pages: 3887-3901, ISSN: 1176-9114
pH-sensitive hydrogels have developed greatly over the past few years. This has been possible due to the synthesis of new hydrogel systems with increased sensitivity - the sensitivity of up to 10-5 pH units have already been established. Recently, pH-sensitive hydrogels have shown to be very useful for biomedical applications, such as targeted cancer treatment and treatment of skin lesions. Prolonged drug release has been made available through the use of such hydrogels. The synthesis of pH-sensitive hydrogels is also quick and cost-effective. This review presents a background on the properties of pH-sensitive hydrogels and discusses some of the hydrogels with different sensitivity ranges and their possible applications. A range of synthesis processes has also been briefly introduced along with the fabrication of different structures such as microcantilevers and contact lenses.
Salih AE, Elsherif M, Ali M, et al., 2020, Ophthalmic Wearable Devices for Color Blindness Management, ADVANCED MATERIALS TECHNOLOGIES, Vol: 5, ISSN: 2365-709X
Dong X, Yetisen AK, Tian H, et al., 2020, Line-Scan Hyperspectral Imaging Microscopy with Linear Unmixing for Automated Two-Dimensional Crystals Identification, ACS PHOTONICS, Vol: 7, Pages: 1216-1225, ISSN: 2330-4022
Dong X, Yetisen AK, Tian H, et al., 2020, Analyses of hyperspectral imaging microscopy data sets of semiconducting 2D materials, APPLIED PHYSICS EXPRESS, Vol: 13, ISSN: 1882-0778
Sharma N, Bergholt MS, Moreddu R, et al., 2020, Clinician engineers – re-injecting the thinking into medicine, Asia Pacific Scholar, Vol: 5, Pages: 48-50, ISSN: 2424-9335
Dong J, Wang S, Yetisen AK, et al., 2020, Shear-unlimited common-path speckle interferometer, OPTICS LETTERS, Vol: 45, Pages: 1305-1308, ISSN: 0146-9592
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