Imperial College London
Alternate

ProfessorAdamWaldman

Faculty of Medicine, Department of Brain Sciences

Visiting Professor
 
 
 
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Contact

 

+44 (0)20 3311 7546adam.waldman

 
 
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Assistant

 

Dr Adam Waldman +44 (0)20 3311 7546

 
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Location

 

Imaging DepartmentCharing Cross HospitalCharing Cross Campus

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Summary

 

Publications

Citation

BibTex format

@article{Turton:2020:10.1038/s41380-018-0107-4,
author = {Turton, S and Myers, J and Mick, I and Colasanti, A and Venkataraman, A and Durant, C and Waldman, A and Brailsford, A and Parkin, M and Rabiner, EA and Gunn, R and Lightman, S and Nutt, D and Lingford-Hughes, AR},
doi = {10.1038/s41380-018-0107-4},
journal = {Molecular Psychiatry},
pages = {1749--1758},
title = {Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol dependent individuals},
url = {http://dx.doi.org/10.1038/s41380-018-0107-4},
volume = {25},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Addiction has been proposed as a ‘reward deficient’ state, which is compensated for with substance use. There is growing evidence of dysregulation in the opioid system, which plays a key role in reward, underpinning addiction. Low levels of endogenous opioids are implicated in vulnerability for developing alcohol dependence (AD) and high mu-opioid receptor (MOR) availability in early abstinence is associated with greater craving. This high MOR availability is proposed to be the target of opioid antagonist medication to prevent relapse. However, changes in endogenous opioid tone in AD are poorly characterised and are important to understand as opioid antagonists do not help everyone with AD. We used [11C]carfentanil, a selective MOR agonist positron emission tomography (PET) radioligand, to investigate endogenous opioid tone in AD for the first time. We recruited 13 abstinent male AD and 15 control participants who underwent two [11C]carfentanil PET scans, one before and one 3 h following a 0.5 mg/kg oral dose of dexamphetamine to measure baseline MOR availability and endogenous opioid release. We found significantly blunted dexamphetamine-induced opioid release in 5 out of 10 regions-of-interest including insula, frontal lobe and putamen in AD compared with controls, but no significantly higher MOR availability AD participants compared with HC in any region. This study is comparable to our previous results of blunted dexamphetamine-induced opioid release in gambling disorder, suggesting that this dysregulation in opioid tone is common to both behavioural and substance addictions.
AU  - Turton,S
AU  - Myers,J
AU  - Mick,I
AU  - Colasanti,A
AU  - Venkataraman,A
AU  - Durant,C
AU  - Waldman,A
AU  - Brailsford,A
AU  - Parkin,M
AU  - Rabiner,EA
AU  - Gunn,R
AU  - Lightman,S
AU  - Nutt,D
AU  - Lingford-Hughes,AR
DO  - 10.1038/s41380-018-0107-4
EP  - 1758
PY  - 2020///
SN  - 1359-4184
SP  - 1749
TI  - Blunted endogenous opioid release following an oral dexamphetamine challenge in abstinent alcohol dependent individuals
T2  - Molecular Psychiatry
UR  - http://dx.doi.org/10.1038/s41380-018-0107-4
UR  - http://hdl.handle.net/10044/1/60048
VL  - 25
ER  -
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