Imperial College London
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DrAilsaHart

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Professor of Practice
 
 
 
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Contact

 

ailsa.hart

 
 
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Location

 

Northwick ParkNorthwick Park and St Marks Site

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Summary

 

Publications

Citation

BibTex format

@article{Al-Hassi:2013:10.1038/mi.2012.113,
author = {Al-Hassi, HO and Bernardo, D and Murugananthan, AU and Mann, ER and English, NR and Jones, A and Kamm, MA and Arebi, N and Hart, AL and Blakemore, AI and Stagg, AJ and Knight, SC},
doi = {10.1038/mi.2012.113},
journal = {Mucosal Immunology},
pages = {751--761},
title = {A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn's disease},
url = {http://dx.doi.org/10.1038/mi.2012.113},
volume = {6},
year = {2013}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Dendritic cells (DC) migrate to lymph nodes on expression of C-C motif chemokine receptor 7 (CCR7) and control immune activity. Leptin, an immunomodulatory adipokine, functions via leptin receptors, signaling via the long isoform of receptor, LepRb. Leptin promotes DC maturation and increases CCR7 expression on blood DC. Increased mesenteric fat and leptin occur early in Crohn's disease (CD), suggesting leptin-mediated change in intestinal CCR7 expression on DC as a pro-inflammatory mechanism. We have demonstrated CCR7 expression and capacity to migrate to its ligand macrophage inflammatory protein 3beta in normal human ileal DC but not colonic or blood DC. In CD, functional CCR7 was expressed on DC from all sites. Only DC populations containing CCR7-expressing cells produced LepRb; in vitro exposure to leptin also increased expression of functional CCR7 in intestinal DC in a dose-dependent manner. In conclusion, leptin may regulate DC migration from gut, in homeostatic and inflammatory conditions, providing a link between mesenteric obesity and inflammation.
AU  - Al-Hassi,HO
AU  - Bernardo,D
AU  - Murugananthan,AU
AU  - Mann,ER
AU  - English,NR
AU  - Jones,A
AU  - Kamm,MA
AU  - Arebi,N
AU  - Hart,AL
AU  - Blakemore,AI
AU  - Stagg,AJ
AU  - Knight,SC
DO  - 10.1038/mi.2012.113
EP  - 761
PY  - 2013///
SN  - 1933-0219
SP  - 751
TI  - A mechanistic role for leptin in human dendritic cell migration: differences between ileum and colon in health and Crohn's disease
T2  - Mucosal Immunology
UR  - http://dx.doi.org/10.1038/mi.2012.113
UR  - http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Citation&list_uids=23168838
UR  - http://hdl.handle.net/10044/1/63927
VL  - 6
ER  -
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