Imperial College London
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DrAkaalKaur

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Research Coordinator
 
 
 
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Contact

 

+44 (0)20 7594 5960akaal.kaur10 Website

 
 
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Location

 

Room 322ICTEM buildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Kaur:2016:10.1530/EJE-16-0095,
author = {Kaur, A and Johnston, DG and Godsland, IF},
doi = {10.1530/EJE-16-0095},
journal = {European Journal of Endocrinology},
pages = {133--143},
title = {Does metabolic health in overweight and obesity persist? - Individual variation and cardiovascular mortality over two decades},
url = {http://dx.doi.org/10.1530/EJE-16-0095},
volume = {175},
year = {2016}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective: Overweight and obese individuals may be metabolically healthy but attention needs to be given to long-term persistence of this trait and any associated variation in cardiovascular risk.Design: Cross-sectional and longitudinal variation in metabolic health and associated cardiovascular mortality were analysed in 1099 white European-origin normal weight and overweight or obese males followed for 20 years.Methods: Definitions of metabolic health were based on LDL and HDL cholesterol, triglycerides, blood pressure, fasting glucose and cardiovascular risk. Insulin resistance (e.g. HOMA-IR) and subclinical inflammation (ESR and white blood cell count) were explored. Cardiovascular mortality risks and persistence of metabolic health status were evaluated.Results: There were 87 cardiovascular deaths. Insulin resistance was increased in metabolically healthy overweight or obese participants (median HOMA-IR 2.63, 95%ci 1.79-3.65, p<0.001) relative to normal weight (median HOMA-IR 1.67, 95%ci 1.08-2.67, p<0.001) as was subclinical inflammation but metabolically healthy overweight or obese individuals were not at increased risk of cardiovascular mortality compared with the metabolically healthy normal-weight (hazard ratio 1.13, 95% ci 0.34-3.72, p=0.8). The proportions of initially metabolically healthy overweight or obese who remained metabolically healthy for visits 2, 3 and 4 were 54, 48 and 39%, respectively, and for initially normal-weight individuals, 68, 51 and 41%. A lower proportion of metabolically healthy overweight or obese individuals remained metabolically healthy at visit 2 compared with normal weight individuals (p=0.007) but proportions converged thereafter..Conclusions: Despite being insulin resistant and having greater subclinical inflammation, and despite instability in metabolic health status, metabolically healthy overweight or obese individuals were at no greater risk of cardiovascular mortality than their normal-weight equivalents.
AU  - Kaur,A
AU  - Johnston,DG
AU  - Godsland,IF
DO  - 10.1530/EJE-16-0095
EP  - 143
PY  - 2016///
SN  - 1479-683X
SP  - 133
TI  - Does metabolic health in overweight and obesity persist? - Individual variation and cardiovascular mortality over two decades
T2  - European Journal of Endocrinology
UR  - http://dx.doi.org/10.1530/EJE-16-0095
UR  - http://hdl.handle.net/10044/1/34151
VL  - 175
ER  -
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