Imperial College London
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DrAlessiaDavid

Faculty of Natural Sciences, Department of Life Sciences

Lecturer in Bioinformatics and Data Intensive Biology
 
 
 
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Contact

 

+44 (0)20 7594 5333alessia.david09

 
 
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Location

 

Department of BioinformaticsSir Ernst Chain BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ittisoponpisan:2022,
author = {Ittisoponpisan, S and Yahangkiakan, S and Sternberg, M and David, A},
journal = {Songklanakarin Journal of Science and Technology},
pages = {1201--1208},
title = {The SARS-CoV-2 infections in Thailand: Analysis of spike mutations complemented by protein structure insights},
url = {http://hdl.handle.net/10044/1/100815},
volume = {44},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Thailand was the first country outside China to officially report COVID-19 cases. With a large number of SARS-CoV-2 sequences collected from patients, the effects of many genetic variations, especially those unique to Thai strains, are yet to be elucidated. In this study, we analyzed 439,197 sequences of the SARS-CoV-2 spike protein collected from NCBI and GISAIDdatabases. 595 sequences were from Thailand and contained 52 amino acid mutations, of which 6 had not been observed outside Thailand (p.T51N, p.P57T, p.I68R, p.S205T, p.K278T, p.G832C). These mutations were not predicted to be of concern. We demonstrate that p.D614G became the prevalent strain during the second outbreak, and the most common spike mutations detected in Thailand (p.A829T, p.S459F and p.S939F) do not appear to cause any major structural change to the spike trimer or the spike-ACE2 interaction. Among the spike mutations identified in Thailand was p.N501T. This mutation was not predicted to increase SARS-CoV-2 binding, in contrast to the spike mutation of interest p.N501Y. In conclusion, Thailand-specific mutations are unlikely to increase the fitness of SARS-CoV-2. The insights obtained from this study could aid in prioritizing SARS-CoV-2variants and in strain surveillance.
AU  - Ittisoponpisan,S
AU  - Yahangkiakan,S
AU  - Sternberg,M
AU  - David,A
EP  - 1208
PY  - 2022///
SN  - 0125-3395
SP  - 1201
TI  - The SARS-CoV-2 infections in Thailand: Analysis of spike mutations complemented by protein structure insights
T2  - Songklanakarin Journal of Science and Technology
UR  - http://hdl.handle.net/10044/1/100815
VL  - 44
ER  -
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