Imperial College London

Dr Alex Ivanov

Faculty of Natural SciencesDepartment of Chemistry

Senior Lecturer



+44 (0)20 7594 5752alex.ivanov Website




Mr John Murrell +44 (0)20 7594 2845




110JMolecular Sciences Research HubWhite City Campus





Dr Alex Ivanov is Senior Lecturer (Assoc. Prof.) at the Department of Chemistry. His research focuses on the innovation of novel nanoscale sensors and platforms for single-molecule detection and delivery, that enable the studying of fundamentally important molecules in chemistry, biology, and medicine. Examples include tunnelling nanopore platform for high-resolution DNA fragment sizing and sequencing Nano Letters (2011), ACS Nano (2014), Nature Communications (2021A), Science Advances (2022), optical/plasmonic nanopore platforms Nano Letters (2013, 2015); ACS Nano (2015A), methods for on-demand delivery of single molecules  ACS Nano (2015B), single-molecule detection in ultra-dilute (fM) samples Nature Communications (2016), nanopore/field-effect transistors for selective bioanalyte sensing Nature Communications (2017A), zeptolitre confinement of single molecules Nano Letters (2017, 2018), multiplexed single-molecule protein detection in human serum, Nature Communications (2017B, 2019,2021B), Nature Nanotechnology (2023), single-molecule nanotweezers that can extract single DNA, proteins and organelles from living cells, Nature Nanotechnology (2019) to name a few.

Research Interests:


Single-molecule and single-cell methods

Nanopore platforms, single-molecule delivery, and detection (nucleic acids and proteins)

Single-molecule biomarker detection (cancer, neurodegeneration, cardiovascular disease, ...)

Point-of-care diagnostics

Alex's research publications can be found at the tab above, or on GoogleScholar

Research Highlights:

Nanopore sequencing and DNA barcoding method gives hope of personalised medicine Nature Nanotechnology

Imperial College Website, Nature Nanotechnology IEEE Spectrum

Nanoscale tweezers can perform single-molecule ‘biopsies’ on individual cells Nature Nanotechnology

Imperial College Website, Nature Medicine Physicsworld

Reading of biological molecules improved up to 100x by doubling the sensors Nano Letters

Imperial College Website,

Single-molecule multiplexed nanopore protein screening in human serum Nature Communications

Imperial College Website,

Nanopore field-effect transistor for selective single-molecule biosensing Nature Communications

Imperial College Website,

High-throughput Molecular Detection Nature Communications 

Imperial College Website,  Nanowerk

DNA Tunneling Detector  Nano Letters

Imperial College Website,  Nanowerk

RECENT Reviews from the group:

Recent advances in single-cell subcellular sampling Chemical Communications (2023)

Solid-state nanopore sensors Nature Reviews Materials (2020)

In situ solid-state nanopore fabrication Chem. Soc. Rev. (2021)

Selected Publications

Journal Articles

Koch C, Reilly-O’Donnell B, Gutierrez R, et al., 2023, Nanopore sequencing of DNA-barcoded probes for highly multiplexed detection of microRNA, proteins and small biomarkers, Nature Nanotechnology, Vol:18, ISSN:1748-3387, Pages:1483-1491

Liu Y, Wang X, Campolo G, et al., 2023, Single-molecule detection of α-Synuclein oligomers in Parkinson's disease patients using nanopores, ACS Nano, Vol:17, ISSN:1936-0851, Pages:22999-23009

Wang X, Thomas T-M, Ren R, et al., 2023, Nanopore detection using supercharged polypeptide molecular carriers, Journal of the American Chemical Society, Vol:145, ISSN:0002-7863, Pages:6371-6382

Tang L, Yi L, Jiang T, et al., 2022, Measuring conductance switching in single proteins using quantum tunneling, Science Advances, Vol:8, ISSN:2375-2548, Pages:1-8

Ren R, Sun M, Goel P, et al., 2021, Single-molecule binding assay using nanopores and dimeric NP conjugates, Advanced Materials, Vol:33, ISSN:0935-9648

Cai S, Pataillot-Meakin T, Shibakawa A, et al., 2021, Single-molecule amplification-free multiplexed detection of circulating microRNA cancer biomarkers from serum, Nature Communications, Vol:12, ISSN:2041-1723

Fried JP, Swett JL, Nadappuram BP, et al., 2021, In situ solid-state nanopore fabrication., Chemical Society Reviews, ISSN:0306-0012

Tang L, Paulose Nadappuram B, Cadinu P, et al., 2021, Combined quantum tunnelling and dielectrophoretic trapping for molecular analysis at ultra-low analyte concentrations, Nature Communications, Vol:12, ISSN:2041-1723, Pages:1-8

Xue L, Yamazaki H, Ren R, et al., 2020, Solid-state nanopore sensors, Nature Reviews Materials, Vol:5, ISSN:2058-8437, Pages:931-951

Cai S, Sze JYY, Ivanov AP, et al., 2019, Small molecule electro-optical binding assay using nanopores., Nat Commun, Vol:10

Paulose Nadappuram B, Cadinu P, Barik A, et al., 2019, Nanoscale tweezers for single-cell biopsies, Nature Nanotechnology, Vol:14, ISSN:1748-3387, Pages:80-88

Cadinu P, Campolo G, Pud S, et al., 2018, Double barrel nanopores as a new tool for controlling single-molecule transport, Nano Letters, Vol:18, ISSN:1530-6984, Pages:2738-2745

Sze JYY, Ivanov AP, Cass AEG, et al., 2017, Single molecule multiplexed nanopore protein screening in human serum using aptamer modified DNA carriers, Nature Communications, Vol:8, ISSN:2041-1723, Pages:1-10

Ren R, Zhang Y, Paulose Nadappuram B, et al., 2017, Nanopore extended field effect transistor for selective single molecule biosensing, Nature Communications, Vol:8, ISSN:2041-1723, Pages:1-9

Cadinu P, Paulose Nadappuram B, Lee DJ, et al., 2017, Single molecule trapping and sensing using dual nanopores separated by a zeptoliter nanobridge, Nano Letters, Vol:17, ISSN:1530-6984, Pages:6376-6384

Edel JB, Freedman K, Otto L, et al., 2016, Nanopore sensing at ultra-low concentrations using single molecule dielectrophoretic trapping, Nature Communications, Vol:7, ISSN:2041-1723, Pages:1-9

Ivanov AP, Actis P, Jönsson P, et al., 2015, On-demand delivery of single DNA molecules using nanopipettes, Acs Nano, Vol:9, ISSN:1936-086X, Pages:3587-3595

More Publications