Imperial College London

Dr Alex Ivanov

Faculty of Natural SciencesDepartment of Chemistry

Lecturer
 
 
 
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Contact

 

alex.ivanov Website

 
 
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Assistant

 

Ms Agnes Lee +44 (0)20 7594 9852

 
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Location

 

110JMolecular Sciences Research HubWhite City Campus

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Summary

 

Summary

Dr Alex Ivanov is a Lecturer (Asst. Prof.at the Department of Chemistry. His research focuses on the innovation of novel nanoscale sensors and platforms for single-molecule detection and delivery, that enable the studying of fundamentally important molecules in chemistry, biology, and medicine. Examples include tunnelling nanopore platform for high-resolution DNA fragment sizing and sequencing Nano Letters (2011), ACS Nano (2014), optical/plasmonic nanopore platforms Nano Letters (2013, 2015); ACS Nano (2015A),methods for on-demand delivery of single molecules  ACS Nano (2015B), single-molecule detection in ultra-dilute (fM) samples Nature Communications (2016), nanopore/field-effect transistors  for selective bioanalyte sensing Nature Communications (2017A), zeptolitre confinement of single molecules Nano Letters (2017, 2018), multiplexed single-molecule protein detection in human serum, Nature Communications (2017B, 2019), single-molecule nanotweezers that can extract single DNA, proteins and organelles from living cells, Nature Nanotechnology (2019) to name a few.


Research Interests:


Nanoelectronics and electrochemistry of single molecules

Single-molecule single-cell methods

Nanopore platforms, single-molecule delivery, and detection (nucleic acids and proteins)

Label-free detection of proteins linked to neurodegeneration

Point-of-care diagnostics

Alex's research publications can be found at the tab above, or on GoogleScholar


Research Highlights:

Nanoscale tweezers can perform single-molecule ‘biopsies’ on individual cells Nature Nanotechnology

Imperial College Website, Nature Medicine Physicsworld

Reading of biological molecules improved up to 100x by doubling the sensors Nano Letters

Imperial College Website,  Phys.org

Single-molecule multiplexed nanopore protein screening in human serum Nature Communications

Imperial College Website,  Phys.org

Nanopore field-effect transistor for selective single-molecule biosensing Nature Communications

Imperial College Website,  Phys.org

High-throughput Molecular Detection Nature Communications 

Imperial College Website,  Nanowerk

DNA Tunneling Detector  Nano Letters

Imperial College Website,  Nanowerk

Selected Publications

Journal Articles

Zhang Y, Takahashi Y, Hong SP, et al., High-resolution label-free 3D mapping of extracellular pH of single living cells, Nature Communications, ISSN:2041-1723

Cai S, Sze JYY, Ivanov AP, et al., 2019, Small molecule electro-optical binding assay using nanopores., Nat Commun, Vol:10

Paulose Nadappuram B, Cadinu P, Barik A, et al., 2019, Nanoscale tweezers for single cell biopsies, Nature Nanotechnology, Vol:14, ISSN:1748-3387, Pages:80-88

Al Sulaiman D, Cadinu P, Ivanov AP, et al., 2018, Chemically modified hydrogel-filled nanopores: a tunable platform for single-molecule sensing, Nano Letters, Vol:18, ISSN:1530-6984, Pages:6084-6093

Cadinu P, Campolo G, Pud S, et al., 2018, Double barrel nanopores as a new tool for controlling single-molecule transport, Nano Letters, Vol:18, ISSN:1530-6984, Pages:2738-2745

Sze JYY, Ivanov AP, Cass AEG, et al., 2017, Single Molecule Multiplexed Nanopore Protein Screening in Human Serum using Aptamer modified DNA Carriers, Nature Communications, Vol:8, ISSN:2041-1723

Ren R, Zhang Y, Paulose Nadappuram B, et al., 2017, Nanopore Extended Field Effect Transistor for Selective Single Molecule Biosensing, Nature Communications, Vol:8, ISSN:2041-1723

Cadinu P, Paulose Nadappuram B, Lee DJ, et al., 2017, Single Molecule Trapping and Sensing Using Dual Nanopores Separated by a Zeptoliter Nanobridge, Nano Letters, Vol:17, ISSN:1530-6984, Pages:6376-6384

Edel JB, Freedman K, Otto L, et al., 2016, Nanopore Sensing at Ultra-low Concentrations using Single Molecule Dielectrophoretic Trapping, Nature Communications, Vol:7, ISSN:2041-1723

Ivanov AP, Actis P, Jönsson P, et al., 2015, On-Demand Delivery of Single DNA Molecules Using Nanopipettes, Acs Nano, Vol:9, ISSN:1936-086X, Pages:3587-3595

Pitchford WH, Kim H-J, Ivanov AP, et al., 2015, Synchronized Optical and Electronic Detection of Biomolecules Using a Low Noise Nanopore Platform, ACS Nano, Vol:9, ISSN:1936-0851, Pages:1740-1748

Crick CR, Albella P, Ng B, et al., 2014, Precise Attolitre Temperature Control of Nanopore Sensors using a Nanoplasmonic Bullseye, Nano Letters, Vol:15, ISSN:1530-6992, Pages:553-559

Ivanov AP, Freedman KJ, Kim MJ, et al., 2014, High Precision Fabrication and Positioning of Nanoelectrodes in a Nanopore, Acs Nano

Miles BN, Ivanov AP, Wilson KA, et al., 2013, Single molecule sensing with solid-state nanopores: novel materials, methods, and applications, Chemical Society Reviews, Vol:42, Pages:15-28

Cecchini MP, Wiener A, Turek V, et al., 2013, Rapid Ultra-Sensitive Single Particle Surface Enhanced Raman Spectroscopy using Metallic Nanopores, Nano Letters

Ivanov AP, Instuli E, McGilvery CM, et al., 2011, DNA tunneling detector embedded in a nanopore, Nano Letters, Vol:11, ISSN:1530-6984, Pages:279-285

More Publications