Imperial College London

Dr Alex Ivanov

Faculty of Natural SciencesDepartment of Chemistry

Junior Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 3156alex.ivanov Website

 
 
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Assistant

 

Mr John Murrell +44 (0)20 7594 2845

 
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Location

 

6.40Flowers buildingSouth Kensington Campus

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Summary

 

Summary

Dr Alex Ivanov is an IC Research Fellow and a group leader at Imperial College London. His research focuses on the innovation of novel nanoscale sensors and platforms for single-molecule delivery, that enable the studying of fundamentally important molecules in chemistry, biology and medicine. Examples include tunnelling nanopore platform for high-resolution DNA fragment sizing and sequencing applications Nano Lett (2011), development of methods for high precision fabrication and positioning of nanoelectrodes in a nanopore ACS Nano (2014), optical/plasmonic nanopore platforms Nano Lett (2013, 2015); ACS Nano (2015A),methods for on-demand delivery of single DNA molecules  ACS Nano (2015B), single molecule detection from ultra-dilute samples using molecular traps Nature Comm (2016), nanopore/field effect transistor devices for selective sensing Nature Comm (2017A), zeptolitre confinement of single molecules Nano Lett (2017) and selective single molecule protein detection in human serum, Nature Comm (2017B), to name a few.


Research Interests:

Nanopore platforms, DNA sequencing

Single molecule delivery and detection (nucleic acids and proteins)

label free detection of proteins linked to neurodegenerative disease (alpha synuclein, amyloid beta, tau)

Alex's research publications can be found at the tab above, or on GoogleScholar


Research Highlights:

Nanopore field-effect transistor for selective single-molecule biosensing

Imperial College Website,  Phys.org,  Nature Communications

High-throughput Molecular Detection

Imperial College Website,  Nanowerk,  Nature Communications

DNA Tunneling Detector 

Imperial College Website,  Nanowerk,  Nano Letters


Positions available:

Currently there are two interdisciplinary PhD projects available, fully funded by the Institute  of Chemical Biology (ICB):

1) New Tools and Strategies to Better Understand Neurodegenerative Disease Progression (in collaboration with Prof Joshua Edel, Prof. Tony Cass and Prof. David Klenerman (University of Cambridge))

2) Cell free DNA size analysis using engineered hydrogel nanopore (EHN) sensors: a non-invasive diagnostic tool for cancer (in collaboration with Dr Sylvain Ladame, Prof Joshua Edel and Prof Charlotte Bevan)

Please note that potential PhD candidates have to meet the ICB criteria

Selected Publications

Journal Articles

Sze JYY, Ivanov AP, Cass AEG, et al., 2017, Single molecule multiplexed nanopore protein screening in human serum using aptamer modified DNA carriers, Nature Communications, Vol:8, ISSN:2041-1723

Cadinu P, Nadappuram BP, Lee DJ, et al., 2017, Single Molecule Trapping and Sensing Using Dual Nanopores Separated by a Zeptoliter Nanobridge, Nano Letters, Vol:17, ISSN:1530-6984, Pages:6376-6384

Ren R, Zhang Y, Nadappuram BP, et al., 2017, Nanopore extended field-effect transistor for selective single-molecule biosensing, Nature Communications, Vol:8, ISSN:2041-1723

Freedman KJ, Otto LM, Ivanov AP, et al., 2016, Nanopore sensing at ultra-low concentrations using single-molecule dielectrophoretic trapping, Nature Communications, Vol:7, ISSN:2041-1723

Ivanov AP, Actis P, Jonsson P, et al., 2015, On-Demand Delivery of Single DNA Molecules Using Nanopipets, ACS Nano, Vol:9, ISSN:1936-0851, Pages:3587-3595

Pitchford WH, Kim H-J, Ivanov AP, et al., 2015, Synchronized Optical and Electronic Detection of Biomolecules Using a Low Noise Nanopore Platform, ACS Nano, Vol:9, ISSN:1936-0851, Pages:1740-1748

Crick CR, Albella P, Ng B, et al., 2015, Precise Attoliter Temperature Control of Nanopore Sensors Using a Nanoplasmonic Bullseye, Nano Letters, Vol:15, ISSN:1530-6984, Pages:553-559

Ivanov AR, Freedman KJ, Kim MJ, et al., 2014, High Precision Fabrication and Positioning of Nanoelectrodes in a Nanopore, ACS Nano, Vol:8, ISSN:1936-0851, Pages:1940-1948

Ivanov AP, Instuli E, McGilvery CM, et al., 2011, DNA tunneling detector embedded in a nanopore, Nano Letters, Vol:11, ISSN:1530-6984, Pages:279-285

Miles BN, Ivanov AP, Wilson KA, et al., 2013, Single molecule sensing with solid-state nanopores: novel materials, methods, and applications, Chemical Society Reviews, Vol:42, ISSN:0306-0012, Pages:15-28

Cecchini MP, Wiener A, Turek VA, et al., 2013, Rapid Ultrasensitive Single Particle Surface-Enhanced Raman Spectroscopy Using Metallic Nanopores, Nano Letters, Vol:13, ISSN:1530-6984, Pages:4602-4609

More Publications