Summary
Dr Alex Ivanov is Senior Lecturer (Assoc. Prof.) at the Department of Chemistry. His research focuses on the innovation of novel nanoscale sensors and platforms for single-molecule detection and delivery, that enable the studying of fundamentally important molecules in chemistry, biology, and medicine. Examples include tunnelling nanopore platform for high-resolution DNA fragment sizing and sequencing Nano Letters (2011), ACS Nano (2014), Nature Communications (2021A), Science Advances (2022), optical/plasmonic nanopore platforms Nano Letters (2013, 2015); ACS Nano (2015A), methods for on-demand delivery of single molecules ACS Nano (2015B), single-molecule detection in ultra-dilute (fM) samples Nature Communications (2016), nanopore/field-effect transistors for selective bioanalyte sensing Nature Communications (2017A), zeptolitre confinement of single molecules Nano Letters (2017, 2018), multiplexed single-molecule protein detection in human serum, Nature Communications (2017B, 2019,2021B), Nature Nanotechnology (2023), single-molecule nanotweezers that can extract single DNA, proteins and organelles from living cells, Nature Nanotechnology (2019) to name a few.
Research Interests:
Nanoelectronics
Single-molecule and single-cell methods
Nanopore platforms, single-molecule delivery, and detection (nucleic acids and proteins)
Single-molecule biomarker detection (cancer, neurodegeneration, cardiovascular disease, ...)
Point-of-care diagnostics
Alex's research publications can be found at the tab above, or on GoogleScholar
Research Highlights:
Nanopore sequencing and DNA barcoding method gives hope of personalised medicine Nature Nanotechnology
Imperial College Website, Nature Nanotechnology, IEEE Spectrum
Nanoscale tweezers can perform single-molecule ‘biopsies’ on individual cells Nature Nanotechnology
Imperial College Website, Nature Medicine, Physicsworld
Reading of biological molecules improved up to 100x by doubling the sensors Nano Letters
Imperial College Website, Phys.org
Single-molecule multiplexed nanopore protein screening in human serum Nature Communications
Imperial College Website, Phys.org,
Nanopore field-effect transistor for selective single-molecule biosensing Nature Communications
Imperial College Website, Phys.org,
High-throughput Molecular Detection Nature Communications
Imperial College Website, Nanowerk
DNA Tunneling Detector Nano Letters
Imperial College Website, Nanowerk
RECENT Reviews from the group:
Recent advances in single-cell subcellular sampling Chemical Communications (2023)
Solid-state nanopore sensors Nature Reviews Materials (2020)
In situ solid-state nanopore fabrication Chem. Soc. Rev. (2021)
Selected Publications
Journal Articles
Koch C, Reilly-O’Donnell B, Gutierrez R, et al., 2023, Nanopore sequencing of DNA-barcoded probes for highly multiplexed detection of microRNA, proteins and small biomarkers, Nature Nanotechnology, Vol:18, ISSN:1748-3387, Pages:1483-1491
Liu Y, Wang X, Campolo G, et al., 2023, Single-molecule detection of α-Synuclein oligomers in Parkinson's disease patients using nanopores, ACS Nano, Vol:17, ISSN:1936-0851, Pages:22999-23009
Wang X, Thomas T-M, Ren R, et al., 2023, Nanopore detection using supercharged polypeptide molecular carriers, Journal of the American Chemical Society, Vol:145, ISSN:0002-7863, Pages:6371-6382
Tang L, Yi L, Jiang T, et al., 2022, Measuring conductance switching in single proteins using quantum tunneling, Science Advances, Vol:8, ISSN:2375-2548, Pages:1-8
Ren R, Sun M, Goel P, et al., 2021, Single-molecule binding assay using nanopores and dimeric NP conjugates, Advanced Materials, Vol:33, ISSN:0935-9648
Cai S, Pataillot-Meakin T, Shibakawa A, et al., 2021, Single-molecule amplification-free multiplexed detection of circulating microRNA cancer biomarkers from serum, Nature Communications, Vol:12, ISSN:2041-1723
Fried JP, Swett JL, Nadappuram BP, et al., 2021, In situ solid-state nanopore fabrication., Chemical Society Reviews, ISSN:0306-0012
Tang L, Paulose Nadappuram B, Cadinu P, et al., 2021, Combined quantum tunnelling and dielectrophoretic trapping for molecular analysis at ultra-low analyte concentrations, Nature Communications, Vol:12, ISSN:2041-1723, Pages:1-8
Xue L, Yamazaki H, Ren R, et al., 2020, Solid-state nanopore sensors, Nature Reviews Materials, Vol:5, ISSN:2058-8437, Pages:931-951
Cai S, Sze JYY, Ivanov AP, et al., 2019, Small molecule electro-optical binding assay using nanopores., Nat Commun, Vol:10
Paulose Nadappuram B, Cadinu P, Barik A, et al., 2019, Nanoscale tweezers for single-cell biopsies, Nature Nanotechnology, Vol:14, ISSN:1748-3387, Pages:80-88
Cadinu P, Campolo G, Pud S, et al., 2018, Double barrel nanopores as a new tool for controlling single-molecule transport, Nano Letters, Vol:18, ISSN:1530-6984, Pages:2738-2745
Sze JYY, Ivanov AP, Cass AEG, et al., 2017, Single molecule multiplexed nanopore protein screening in human serum using aptamer modified DNA carriers, Nature Communications, Vol:8, ISSN:2041-1723, Pages:1-10
Ren R, Zhang Y, Paulose Nadappuram B, et al., 2017, Nanopore extended field effect transistor for selective single molecule biosensing, Nature Communications, Vol:8, ISSN:2041-1723, Pages:1-9
Cadinu P, Paulose Nadappuram B, Lee DJ, et al., 2017, Single molecule trapping and sensing using dual nanopores separated by a zeptoliter nanobridge, Nano Letters, Vol:17, ISSN:1530-6984, Pages:6376-6384
Edel JB, Freedman K, Otto L, et al., 2016, Nanopore sensing at ultra-low concentrations using single molecule dielectrophoretic trapping, Nature Communications, Vol:7, ISSN:2041-1723, Pages:1-9
Ivanov AP, Actis P, Jönsson P, et al., 2015, On-demand delivery of single DNA molecules using nanopipettes, Acs Nano, Vol:9, ISSN:1936-086X, Pages:3587-3595