Imperial College London
Portrait Picture

Dr Alex Thompson

Faculty of Medicine, Department of Surgery & Cancer

Lecturer in Sensing in Cancer
 
 
 
//

Contact

 

alex.thompson08 Website

 
 
//

Location

 

B411Bessemer BuildingSouth Kensington Campus

//

Summary

 

Publications

Citation

BibTex format

@article{Maurice:2020:10.1038/s41598-020-73149-2,
author = {Maurice, J and Lett, A and Skinner, C and Lim, A and Richardson, M and Painadath, Thomas A and Summers, P and Vyas, K and Tadbier, A and Vilar, R and Kuimova, M and Miodragovic, S and Vergis, N and Kelly, P and Cordeiro, M and Hoare, J and Darzi, A and Goldin, R and Thursz, M and Thompson, A},
doi = {10.1038/s41598-020-73149-2},
journal = {Scientific Reports},
title = {Transcutaneous fluorescence spectroscopy as a tool for non-invasive monitoring of gut function: first clinical experiences},
url = {http://dx.doi.org/10.1038/s41598-020-73149-2},
volume = {10},
year = {2020}
}
Download

RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Gastro-intestinal function plays a vital role in conditions ranging from inflammatory bowel disease and HIV through to sepsis and malnutrition. However, the techniques that are currently used to assess gut function are either highly invasive or unreliable. Here we present an alternative, non-invasive sensing modality for assessment of gut function based on fluorescence spectroscopy. In this approach, patients receive an oral dose of a fluorescent contrast agent and a fibre-optic probe is used to make fluorescence measurements through the skin. This provides a readout of the degree to which fluorescent dyes have permeated from the gut into the blood stream. We present preliminary results from our first measurements in human volunteers demonstrating the potential of the technique for non-invasive monitoring of multiple aspects of gastro-intestinal health.
AU  - Maurice,J
AU  - Lett,A
AU  - Skinner,C
AU  - Lim,A
AU  - Richardson,M
AU  - Painadath,Thomas A
AU  - Summers,P
AU  - Vyas,K
AU  - Tadbier,A
AU  - Vilar,R
AU  - Kuimova,M
AU  - Miodragovic,S
AU  - Vergis,N
AU  - Kelly,P
AU  - Cordeiro,M
AU  - Hoare,J
AU  - Darzi,A
AU  - Goldin,R
AU  - Thursz,M
AU  - Thompson,A
DO  - 10.1038/s41598-020-73149-2
PY  - 2020///
SN  - 2045-2322
TI  - Transcutaneous fluorescence spectroscopy as a tool for non-invasive monitoring of gut function: first clinical experiences
T2  - Scientific Reports
UR  - http://dx.doi.org/10.1038/s41598-020-73149-2
UR  - http://hdl.handle.net/10044/1/83422
VL  - 10
ER  -
Download