Imperial College London
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Dr Alex Thompson

Faculty of Medicine, Department of Surgery & Cancer

Lecturer in Sensing in Cancer
 
 
 
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Contact

 

alex.thompson08 Website

 
 
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Location

 

B411Bessemer BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@inproceedings{Monfort:2023:10.1117/12.2649030,
author = {Monfort, Sánchez E and Avery, J and Gan, J and Qian, J and Mwiinga, M and Banda, R and Hoare, J and Ashranfian, H and Darzi, A and Kelly, P and Thompson, AJ},
doi = {10.1117/12.2649030},
pages = {1--7},
publisher = {SPIE},
title = {A compact fluorescence sensor for low-cost non-invasive monitoring of gut permeability in undernutrition},
url = {http://dx.doi.org/10.1117/12.2649030},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - CPAPER
AB  - Undernutrition is associated with approximately 45% of deaths among children under the age of 5. Furthermore, in 2020, around 149 million children suffered impaired physical/cognitive development due to lack of adequate nutrition. Environmental enteropathy (EE) is associated with undernutrition and is characterized by a multifaceted breakdown in gut function, including an increase in intestinal permeability that can lead to inflammatory responses. However, the role and mechanisms associated with EE (particularly gut permeability) are not well understood. This is partly because current techniques to assess changes in gut permeability, such as endoscopic biopsies, histopathology and chemical tests such as Lactulose:Mannitol assays, are either highly invasive, unreliable or difficult to perform on specific groups of patients (such as infants and patients with urine retention problems). Therefore, low-cost, non-invasive and reliable diagnostic tools are urgently needed for better evaluation of intestinal permeability. Here, we present a compact transcutaneous fluorescence spectroscopy sensor for non-invasive evaluation of gut permeability and report the first in vivo data collected from volunteers in an undernutrition trial. Using this technique and device, fluorescence signals are detected transcutaneously after oral ingestion of a fluorescent solution. Preliminary results demonstrate the potential use of the presented sensor for clinical assessment of gut permeability in low-income settings.
AU  - Monfort,Sánchez E
AU  - Avery,J
AU  - Gan,J
AU  - Qian,J
AU  - Mwiinga,M
AU  - Banda,R
AU  - Hoare,J
AU  - Ashranfian,H
AU  - Darzi,A
AU  - Kelly,P
AU  - Thompson,AJ
DO  - 10.1117/12.2649030
EP  - 7
PB  - SPIE
PY  - 2023///
SN  - 1605-7422
SP  - 1
TI  - A compact fluorescence sensor for low-cost non-invasive monitoring of gut permeability in undernutrition
UR  - http://dx.doi.org/10.1117/12.2649030
UR  - https://www.spiedigitallibrary.org/conference-proceedings-of-spie/12369/2649030/A-compact-fluorescence-sensor-for-low-cost-non-invasive-monitoring/10.1117/12.2649030.full
UR  - http://hdl.handle.net/10044/1/104613
ER  -
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