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@article{Vysniauskas:2018:2050-6120/aabb2c,
author = {Vysniauskas, A and Lopez, Duarte I and Thompson, AJ and Bull, JA and Kuimova, MK},
doi = {2050-6120/aabb2c},
journal = {Methods and Applications in Fluorescence},
title = {Surface functionalisation with viscosity-sensitive BODIPY molecular rotor},
url = {http://dx.doi.org/10.1088/2050-6120/aabb2c},
volume = {6},
year = {2018}
}

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TY  - JOUR
AB  - Surface functionalisation with viscosity sensitive dyes termed ‘molecular rotors’ can potentially open up new opportunities in  sensing,  for  example  for  non-invasive  biological  viscosity  imaging,  in  studying  the  effect  of  shear  stress  on  lipid membranes  and  in  cells,  and  in  imaging  contacts  between  surfaces  upon  applied  pressure.  We  have functionalised microscope  slides  with  BODIPY-based molecular rotor  capable  of  viscosity  sensing  via  its  fluorescence  lifetime.  We  have optimised  functionalisation  conditions  and  prepared  the  slides  with  the  BODIPY  rotor  attached  directly to  the  surface  of glass slides and through polymer linkers of 5 kDa and 40 kDa in mass. The slides were characterised for their sensitivity to viscosity, and used to measure viscosity of supported lipid bilayers during photooxidation, and of giant unilamellar vesicles lying on the surface of the slide.  We conclude that our functionalised slides show promise for a variety of viscosity sensing applications.
AU  - Vysniauskas,A
AU  - Lopez,Duarte I
AU  - Thompson,AJ
AU  - Bull,JA
AU  - Kuimova,MK
DO  - 2050-6120/aabb2c
PY  - 2018///
SN  - 2050-6120
TI  - Surface functionalisation with viscosity-sensitive BODIPY molecular rotor
T2  - Methods and Applications in Fluorescence
UR  - http://dx.doi.org/10.1088/2050-6120/aabb2c
UR  - http://hdl.handle.net/10044/1/57554
VL  - 6
ER  -

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