Imperial College London
Alternate

DrAlexisArnaudon

Faculty of Natural Sciences, Department of Mathematics

Academic Visitor
 
 
 
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Contact

 

+44 (0)7463 328 499alexis.arnaudon Website

 
 
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Location

 

6M34Huxley BuildingSouth Kensington Campus

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Summary

 

Publications

Citation

BibTex format

@article{Reimann:2022:10.1101/2022.08.11.503144,
author = {Reimann, MW and Bolaños-Puchet, S and Courcol, J-D and Santander, DE and Arnaudon, A and Coste, B and Delalondre, F and Delemontex, T and Devresse, A and Dictus, H and Dietz, A and Ecker, A and Favreau, C and Ficarelli, G and Gevaert, M and Herttuainen, J and Isbister, JB and Kanari, L and Keller, D and King, J and Kumbhar, P and Lapere, S and Lazovskis, J and Lu, H and Ninin, N and Pereira, F and Planas, J and Pokorny, C and Riquelme, JL and Romani, A and Shi, Y and Smith, JP and Sood, V and Srivastava, M and Van, Geit W and Vanherpe, L and Wolf, M and Levi, R and Hess, K and Schürmann, F and Muller, EB and Ramaswamy, S and Markram, H},
doi = {10.1101/2022.08.11.503144},
title = {Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part I: Anatomy},
url = {http://dx.doi.org/10.1101/2022.08.11.503144},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Abstract</jats:title><jats:p>The function of the neocortex is fundamentally determined by its repeating microcircuit motif, but also by its rich, interregional connectivity. We present a data-driven computational model of the anatomy of non-barrel primary somatosensory cortex of juvenile rat, integrating whole-brain scale data while providing cellular and subcellular specificity. The model consists of 4.2 million morphologically detailed neurons, placed in a digital brain atlas. They are connected by 14.2 billion synapses, comprising local, long-range and extrinsic connectivity. We delineated the limits of determining connectivity from anatomy, finding that it reproduces the targeting of PV+ and VIP+ interneurons only with explicitly added specificity, but the one of Sst+ neurons even without. Globally, connectivity was characterized by local clusters tied together through hub neurons in layer 5, demonstrating how local and interegional connectivity are complicit, inseparable networks. A 211,712 neuron subvolume of the model has been made freely and openly available to the community.</jats:p>
AU  - Reimann,MW
AU  - Bolaños-Puchet,S
AU  - Courcol,J-D
AU  - Santander,DE
AU  - Arnaudon,A
AU  - Coste,B
AU  - Delalondre,F
AU  - Delemontex,T
AU  - Devresse,A
AU  - Dictus,H
AU  - Dietz,A
AU  - Ecker,A
AU  - Favreau,C
AU  - Ficarelli,G
AU  - Gevaert,M
AU  - Herttuainen,J
AU  - Isbister,JB
AU  - Kanari,L
AU  - Keller,D
AU  - King,J
AU  - Kumbhar,P
AU  - Lapere,S
AU  - Lazovskis,J
AU  - Lu,H
AU  - Ninin,N
AU  - Pereira,F
AU  - Planas,J
AU  - Pokorny,C
AU  - Riquelme,JL
AU  - Romani,A
AU  - Shi,Y
AU  - Smith,JP
AU  - Sood,V
AU  - Srivastava,M
AU  - Van,Geit W
AU  - Vanherpe,L
AU  - Wolf,M
AU  - Levi,R
AU  - Hess,K
AU  - Schürmann,F
AU  - Muller,EB
AU  - Ramaswamy,S
AU  - Markram,H
DO  - 10.1101/2022.08.11.503144
PY  - 2022///
TI  - Modeling and Simulation of Neocortical Micro- and Mesocircuitry. Part I: Anatomy
UR  - http://dx.doi.org/10.1101/2022.08.11.503144
ER  -
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