Imperial College London
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DrAliAbbara

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Clinical Senior Lecturer in Diabetes and Endocrinology
 
 
 
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Contact

 

+44 (0)20 3313 4843ali.abbara Website

 
 
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Location

 

6N6Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Dragan:2020:10.1038/s41419-020-2305-7,
author = {Dragan, M and Nguyen, M-U and Guzman, S and Goertzen, C and Brackstone, M and Dhillo, WS and Bech, PR and Clarke, S and Abbara, A and Tuck, AB and Hess, DA and Pine, SR and Zong, W-X and Wondisford, FE and Su, X and Babwah, AV and Bhattacharya, M},
doi = {10.1038/s41419-020-2305-7},
journal = {Cell Death and Disease},
title = {G protein-coupled kisspeptin receptor induces metabolic reprograming and tumorigenesis in estrogen receptor-negative breast cancer},
url = {http://dx.doi.org/10.1038/s41419-020-2305-7},
volume = {11},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Triple-negative breast cancer (TNBC) is a highly metastatic and deadly disease. TNBC tumors lack estrogen receptor (ERα), progesterone receptor (PR), and HER2 (ErbB2) and exhibit increased glutamine metabolism, a requirement for tumor growth. The G protein-coupled kisspeptin receptor (KISS1R) is highly expressed in patient TNBC tumors and promotes malignant transformation of breast epithelial cells. This study found that TNBC patients displayed elevated plasma kisspeptin levels compared with healthy subjects. It also provides the first evidence that in addition to promoting tumor growth and metastasis in vivo, KISS1R-induced glutamine dependence of tumors. In addition, tracer-based metabolomics analyses revealed that KISS1R promoted glutaminolysis and nucleotide biosynthesis by increasing c-Myc and glutaminase levels, key regulators of glutamine metabolism. Overall, this study establishes KISS1R as a novel regulator of TNBC metabolism and metastasis, suggesting that targeting KISS1R could have therapeutic potential in the treatment of TNBC.
AU  - Dragan,M
AU  - Nguyen,M-U
AU  - Guzman,S
AU  - Goertzen,C
AU  - Brackstone,M
AU  - Dhillo,WS
AU  - Bech,PR
AU  - Clarke,S
AU  - Abbara,A
AU  - Tuck,AB
AU  - Hess,DA
AU  - Pine,SR
AU  - Zong,W-X
AU  - Wondisford,FE
AU  - Su,X
AU  - Babwah,AV
AU  - Bhattacharya,M
DO  - 10.1038/s41419-020-2305-7
PY  - 2020///
SN  - 2041-4889
TI  - G protein-coupled kisspeptin receptor induces metabolic reprograming and tumorigenesis in estrogen receptor-negative breast cancer
T2  - Cell Death and Disease
UR  - http://dx.doi.org/10.1038/s41419-020-2305-7
UR  - https://www.ncbi.nlm.nih.gov/pubmed/32034133
UR  - http://hdl.handle.net/10044/1/77357
VL  - 11
ER  -
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