Imperial College London
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DrAliAbbara

Faculty of Medicine, Department of Metabolism, Digestion and Reproduction

Clinical Senior Lecturer in Diabetes and Endocrinology
 
 
 
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Contact

 

+44 (0)20 3313 4843ali.abbara Website

 
 
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Location

 

6N6Commonwealth BuildingHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Yang:2020:10.1172/jci.insight.133633,
author = {Yang, L and Demetriou, L and Wall, M and Mills, E and Zargaran, D and Sykes, M and Prague, J and Abbara, A and Owen, B and Bassett, P and Rabiner, E and Comninos, A and Dhillo, W},
doi = {10.1172/jci.insight.133633},
journal = {JCI insight},
title = {Kisspeptin enhances brain responses to olfactory and visual cues of attraction in men},
url = {http://dx.doi.org/10.1172/jci.insight.133633},
volume = {5},
year = {2020}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Successful  reproduction  is  a  fundamental  physiological  process  which  relies  on  the  integration  of sensory  cues  of  attraction  with  appropriate  emotions  and  behaviors  and  the  reproductive  axis. However,  the  factors  responsible  for  this  integration  remain  largely  unexplored.  Using  functional neuroimaging,   hormonal   and   psychometric   analyses,   we   demonstrate that   the   reproductive hormone kisspeptin enhances brain activity in response to olfactory and visual cues of attraction in men.  Furthermore,  the  brain  regions  enhanced  by  kisspeptin  correspond  to  areas  within  the olfactory  and  limbic  systems  that  govern  sexual  behavior  and  perception  of  beauty  as  well  as overlapping with its endogenous expression pattern. Of key functional and behavioral significance, we  observed  that  kisspeptin  was  most  effective  in  men  with  lower  sexual  quality of  life  scores.  As such,  our  results  reveal  a  previously  undescribed  attraction  pathway  in  humans  activated  by kisspeptin, and identify kisspeptin signaling as a new therapeutic target for related reproductive and psychosexual disorders.
AU  - Yang,L
AU  - Demetriou,L
AU  - Wall,M
AU  - Mills,E
AU  - Zargaran,D
AU  - Sykes,M
AU  - Prague,J
AU  - Abbara,A
AU  - Owen,B
AU  - Bassett,P
AU  - Rabiner,E
AU  - Comninos,A
AU  - Dhillo,W
DO  - 10.1172/jci.insight.133633
PY  - 2020///
SN  - 2379-3708
TI  - Kisspeptin enhances brain responses to olfactory and visual cues of attraction in men
T2  - JCI insight
UR  - http://dx.doi.org/10.1172/jci.insight.133633
UR  - http://hdl.handle.net/10044/1/76720
VL  - 5
ER  -
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