Dr. Ali Salehi-Reyhani is an Imperial College Research Fellow in the Department of Chemistry. He is a member of the Chemical Biology and Healthcare, Environmental and Green Chemistry, and Imaging, Sensing and Analytical Chemistry research themes.
His interests centre on the development, application and translation of novel analytical instrumentation. The unifying focus of our work is to explore and better understand cellular signalling networks and behaviour to ultimately improve health and patient outcomes. You can find a general description of the work in the ASR Group on the Research tab. Our current work includes microfluidic technology to quantitatively analyse proteins within single cells and a portable point-of-care diagnostic based on HPLC for the early detection of cancer.
Ali works within the Institute of Chemical Biology, which supports and develops multidisciplinary research crossing the physical sciences-life sciences/biomedical interface. In particular, the ICB focuses on the development and application of novel tools and technology for solving major problems in the life and biomedical sciences.
Ali originally trained as a physicist (BSc) specialising in optics and photonics (MSc) at Imperial. His research career has been at the frontier of multidisciplinary science, spanning protein and membrane chemical biology (MRes) where he developed methods of microscopy to monitor cell metabolism and pioneered platform technologies for quantitative single cell analysis (PhD/Postdoc). Ali is the Founder and Director of anywhereHPLC Ltd., a technology spin-out of Imperial College miniaturising high performance liquid chromatography to a handheld device.
You can find our full news feed on the ASR Group tab.
- Oct 2016 Ali is invited to help launch the I-HUB, Imperial's new translation and innovation hub, with an exhibition of anywhereHPLC and a talk at the Global Challenges Showcase. Learn more.
- Sep 2016 Our optical trap and microbead racetrack goes to New Scientist Live! Learn more.
- Jul 2016 Ali was part of the winning team in the recent EMBRACE Sandpit on Antimicrobial Resistance Collaboration, to work on a project promoting immune clearance of infections. Learn more.
- Apr 2016 Stelios’ start-up BioNet named winner of the 2016 Venture Catalyst Challenge taking home £10k in prize money. Learn more.
- Mar 2016 Pashiini's team take home 3rd prize at Chemistry's E&I pitch event with RiskE, an idea for a computer assisted COSHH generator.
- Jun/Jul 2015 Single Cell science exhibit at the Royal Society Summer Science Exhibition. Learn more.
I'm always looking for talented students and postdocs who want to join us. If you are interested in applying, please e-mail me your CV and a description of your research interests.
Our projects are ideal for enthusiastic and driven scientists who are excited by building and applying analytical instrumentation for translational research. You will work with bioengineers, chemists and clinicians which requires a highly multidisciplinary approach; analytical chemistry, droplet microfluidics, instrument design and engineering, programming, multidimensional single-molecule microscopy and systems biology.
PHD (& MRES) STUDENTSHIPS
We welcome talented students interested in pursuing postgraduate research in our group. All prospective applicants should have or expect to obtain a degree (or equivalent) in chemistry, biochemistry, physics, mathematics or a closely related discipline. Non-UK students must be able to obtain independent funding for their studies, which we will help in identifying schemes and preparing competitive applications. There are a number of funding schemes for PhD students, see for example Imperial’s scholarship search engine. Please contact me directly if you are interested.
We welcome enquiries from potential postdoctoral fellows who wish to apply for independent research funding, which we will help in preparing a research proposal. For funding, please check this list of research fellowships. We have a good track record of training and supporting the research of early career researchers e.g. Whitaker International Fellow and Marie Curie Fellows. Please contact me directly if you are interested.
UNDERGRADUATE RESEARCH OPPORTUNITIES
Undergraduates who are interested in a summer research placement are encouraged to get in touch. We are a popular group for students wishing to develop real research experience due to our multidisciplinarity and wide-range of expertise. Please refer to Imperial’s UROP page for information about eligibility and sources of funding before contacting me if you are interested.
et al., 2018, Counting Proteins in Single Cells with Addressable Droplet Microarrays., J Vis Exp
et al., 2018, Sculpting and fusing biomimetic vesicle networks using optical tweezers, Nature Communications, Vol:9, ISSN:2041-1723
Salehi-Reyhani A, Ces O, Elani Y, 2017, Artificial cell mimics as simplified models for the study of cell biology, Experimental Biology and Medicine, Vol:242, ISSN:1535-3702, Pages:1309-1317
et al., 2017, Protein degradation rate is the dominant mechanism accounting for the differences in protein abundance of basal p53 in a human breast and colorectal cancer cell line, Plos One, Vol:12, ISSN:1932-6203
Salehi-Reyhani A, 2017, Evaluating single molecule detection methods for microarrays with high dynamic range for quantitative single cell analysis, Scientific Reports, Vol:7, ISSN:2045-2322