Imperial College London

Dr Ali Salehi-Reyhani

Faculty of Natural SciencesDepartment of Chemistry

Honorary Research Fellow
 
 
 
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Contact

 

+44 (0)20 7594 1824ali.salehi-reyhani

 
 
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Location

 

536ChemistrySouth Kensington Campus

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Summary

 

Publications

Publication Type
Year
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17 results found

Bolognesi G, Friddin MS, Salehi-Reyhani A, Barlow NE, Brooks NJ, Ces O, Elani Yet al., 2018, Sculpting and fusing biomimetic vesicle networks using optical tweezers, NATURE COMMUNICATIONS, Vol: 9, ISSN: 2041-1723

JOURNAL ARTICLE

Chatzimichail S, Supramaniam P, Ces O, Salehi-Reyhani Aet al., 2018, Counting Proteins in Single Cells with Addressable Droplet Microarrays, JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, ISSN: 1940-087X

JOURNAL ARTICLE

Chatzimichail S, Supramaniam P, Ces O, Salehi-Reyhani Aet al., 2018, Micropatterning of planar metal electrodes by vacuum filling microfluidic channel geometries, SCIENTIFIC REPORTS, Vol: 8, ISSN: 2045-2322

JOURNAL ARTICLE

Trantidou T, Friddin MS, Salehi-Reyhani A, Ces O, Elani Yet al., 2018, Droplet microfluidics for the construction of compartmentalised model membranes, LAB ON A CHIP, Vol: 18, Pages: 2488-2509, ISSN: 1473-0197

JOURNAL ARTICLE

Salehi-Reyhani A, Ces O, Elani Y, 2017, Artificial cell mimics as simplified models for the study of cell biology, EXPERIMENTAL BIOLOGY AND MEDICINE, Vol: 242, Pages: 1309-1317, ISSN: 1535-3702

JOURNAL ARTICLE

Casey DR, Wylie D, Gallo J, Dent MR, Salehi-Reyhani A, Wilson R, Brooks NJ, Long NJ, Willison KR, Klug DR, Neil MAA, Neale SL, Cooper JM, Ces Oet al., 2015, A Novel, all-optical tool for controllable and non-destructive poration of cells with single-micron resolution

© OSA 2015. We demonstrate controllable poration within ≈1 μm regions of individual cells, mediated by a near-IR laser interacting with thin-layer amorphous silicon substrates. This technique will allow new experiments in single-cell biology, particularly in neuroscience. As our understanding of the fundamental mechanistic processes underpinning biology expands, so does the need for high-precision tools to allow the dissection of the heterogeneity and stochastic processes that dominate at the single- and sub-cellular level. Here, we demonstrate a highly controllable and reproducible optical technique for inducing poration within specific regions of a target cell's plasma membrane, permitting localized delivery of payloads, depolarization and lysis experiments to be conducted in unprecedented detail. Experiments support a novel mechanism for the process, based upon a thermally-induced change triggered by the interactions of a near-IR laser with a biocompatible thin film substrate at powers substantially below that used in standard optoporation experiments.

CONFERENCE PAPER

Salehi-Reyhani A, Gesellchen F, Mampallil D, Wilson R, Reboud J, Ces O, Willison KR, Cooper JM, Klug DRet al., 2015, Chemical-Free Lysis and Fractionation of Cells by Use of Surface Acoustic Waves for Sensitive Protein Assays, ANALYTICAL CHEMISTRY, Vol: 87, Pages: 2161-2169, ISSN: 0003-2700

JOURNAL ARTICLE

Willison KR, Salehi-Reyhani A, Burgin E, Barclay M, Brown A, Neil MA, Ces O, Klug DRet al., 2015, Absolute quantification of protein copy number in single cells using single molecule microarrays, EUROPEAN BIOPHYSICS JOURNAL WITH BIOPHYSICS LETTERS, Vol: 44, Pages: S179-S179, ISSN: 0175-7571

JOURNAL ARTICLE

Burgin E, Salehi-Reyhani A, Barclay M, Brown A, Kaplinsky J, Novakova M, Neil MAA, Ces O, Willison KR, Klug DRet al., 2014, Absolute quantification of protein copy number using a single-molecule-sensitive microarray, ANALYST, Vol: 139, Pages: 3235-3244, ISSN: 0003-2654

JOURNAL ARTICLE

Salehi-Reyhani A, Burgin E, Ces O, Willison KR, Klug DRet al., 2014, Addressable droplet microarrays for single cell protein analysis, ANALYST, Vol: 139, Pages: 5367-5374, ISSN: 0003-2654

JOURNAL ARTICLE

Salehi-Reyhani A, Sharma S, Burgin E, Barclay M, Cass A, Neil MAA, Ces O, Willison KR, Klug DR, Brown A, Novakova Met al., 2014, Scaling advantages and constraints in miniaturized capture assays for single cell protein analysis (vol 13, pg 2066, 2013), LAB ON A CHIP, Vol: 14, Pages: 3430-3430, ISSN: 1473-0197

JOURNAL ARTICLE

Salehi-Reyhani A, Sharma S, Burgin E, Barclay M, Cass A, Neil MAA, Ces O, Willison KR, Klug DRet al., 2013, Scaling advantages and constraints in miniaturized capture assays for single cell protein analysis, LAB ON A CHIP, Vol: 13, Pages: 2066-2074, ISSN: 1473-0197

JOURNAL ARTICLE

Salehi-Reyhani A, Barclay M, Ces O, Willison K, Klug Det al., 2012, Towards Practical Single Cell Proteomics: A Microfluidic Antibody Capture Chip with TIRF Detection, FREE RADICAL BIOLOGY AND MEDICINE, Vol: 53, Pages: S128-S128, ISSN: 0891-5849

JOURNAL ARTICLE

Sharma S, Salehi-Reyhani A, Bahrami A, Intisar E, Santhanam H, Michelakis K, Cass Aet al., 2012, Method for fabricating nanostructures via nanotemplates using dip-pen nanolithography, MICRO & NANO LETTERS, Vol: 7, Pages: 1038-1040, ISSN: 1750-0443

JOURNAL ARTICLE

Salehi-Reyhani A, Kaplinsky J, Burgin E, Novakova M, deMello AJ, Templer RH, Parker P, Neil MAA, Ces O, French P, Willison KR, Klug Det al., 2011, A first step towards practical single cell proteomics: a microfluidic antibody capture chip with TIRF detection, LAB ON A CHIP, Vol: 11, Pages: 1256-1261, ISSN: 1473-0197

JOURNAL ARTICLE

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