Imperial College London
Alternate

ProfessorAlisonHolmes

Faculty of Medicine, Department of Infectious Disease

Professor of Infectious Diseases
 
 
 
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Contact

 

+44 (0)20 3313 1283alison.holmes

 
 
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Location

 

8N16Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Zemanick:2019:10.1016/j.jcf.2019.10.006,
author = {Zemanick, E and Burgel, P-R and Taccetti, G and Holmes, A and Ratjen, F and Byrnes, CA and Waters, VJ and Bell, SC and VanDevanter, DR and Stuart, Elborn J and Flume, PA and Antimicrobial, Resistance International Working Group in Cystic Fibrosis},
doi = {10.1016/j.jcf.2019.10.006},
journal = {Journal of Cystic Fibrosis},
pages = {370--375},
title = {Antimicrobial resistance in cystic fibrosis: a Delphi approach to defining best practices},
url = {http://dx.doi.org/10.1016/j.jcf.2019.10.006},
volume = {19},
year = {2019}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Antimicrobial susceptibility testing (AST) is a cornerstone of infection management in cystic fibrosis. However, there is little evidence that AST predicts the clinical outcome of CF antimicrobial treatment. It has been suggested there is a need for careful consideration of current AST use by the CF community. METHODS: We engaged a group of experts consisting of pulmonary (adult and pediatric) and infectious disease clinicians, microbiologists, and pharmacists representing a broad international experience. We conducted an iterative systematic survey (Delphi) to determine and quantify consensus regarding key questions facing CF clinicians in the use of respiratory culture results including what tests to order, when to obtain them, and how to act upon the results of the testing. RESULTS: Consensus was reached for many questions but there was not universal agreement to the questions that were addressed. There were some differences with respect to cultures obtained for surveillance compared to when there is clinical worsening. Areas of general consensus include when and how respiratory cultures should be performed, what information should be reported, and when AST should be performed. A key finding is that clinical response to treatment is used to guide treatment decisions rather than AST results. CONCLUSIONS: Recommendations are presented regarding questions related to microbiology testing for patients with CF. We have also offered recommendations for priority research questions.
AU  - Zemanick,E
AU  - Burgel,P-R
AU  - Taccetti,G
AU  - Holmes,A
AU  - Ratjen,F
AU  - Byrnes,CA
AU  - Waters,VJ
AU  - Bell,SC
AU  - VanDevanter,DR
AU  - Stuart,Elborn J
AU  - Flume,PA
AU  - Antimicrobial,Resistance International Working Group in Cystic Fibrosis
DO  - 10.1016/j.jcf.2019.10.006
EP  - 375
PY  - 2019///
SN  - 1569-1993
SP  - 370
TI  - Antimicrobial resistance in cystic fibrosis: a Delphi approach to defining best practices
T2  - Journal of Cystic Fibrosis
UR  - http://dx.doi.org/10.1016/j.jcf.2019.10.006
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31680041
UR  - https://www.sciencedirect.com/science/article/pii/S1569199319309191?via%3Dihub
UR  - http://hdl.handle.net/10044/1/75567
VL  - 19
ER  -
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