Imperial College London
Alternate

ProfessorAlisonHolmes

Faculty of Medicine, Department of Infectious Disease

Professor of Infectious Diseases
 
 
 
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Contact

 

+44 (0)20 3313 1283alison.holmes

 
 
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Location

 

8N16Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Ming:2022:10.1136/bmjinnov-2021-000864,
author = {Ming, DK and Jangam, S and Gowers, SAN and Wilson, R and Freeman, DME and Boutelle, MG and Cass, AEG and OHare, D and Holmes, AH},
doi = {10.1136/bmjinnov-2021-000864},
journal = {BMJ Innovations},
pages = {87--94},
title = {Real-time continuous measurement of lactate through a minimally invasive microneedle patch: a phase I clinical study},
url = {http://dx.doi.org/10.1136/bmjinnov-2021-000864},
volume = {8},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Introduction Determination of blood lactate levels supports decision-making in a range of medical conditions. Invasive blood-sampling and laboratory access are often required, and measurements provide a static profile at each instance. We conducted a phase I clinical study validating performance of a microneedle patch for minimally invasive, continuous lactate measurement in healthy volunteers.Methods Five healthy adult participants wore a solid microneedle biosensor patch on their forearms and undertook aerobic exercise for 30 min. The microneedle biosensor quantifies lactate concentrations in interstitial fluid within the dermis continuously and in real-time. Outputs were captured as sensor current and compared with lactate concentrations from venous blood and microdialysis.Results The biosensor was well-tolerated. Participants generated a median peak venous lactate of 9.25 mmol/L (IQR 6.73–10.71). Microdialysate concentrations of lactate closely correlated with blood. Microneedle biosensor current followed venous lactate concentrations and dynamics, with good agreement seen in all participants. There was an estimated lag-time of 5 min (IQR −4 to 11 min) between microneedle and blood lactate measurements.Conclusion This study provides first-in-human data on use of a minimally invasive microneedle patch for continuous lactate measurement, providing dynamic monitoring. This low-cost platform offers distinct advantages to frequent blood sampling in a wide range of clinical settings, especially where access to laboratory services is limited or blood sampling is infeasible. Implementation of this technology in healthcare settings could support personalised decision-making in a variety of hospital and community settings.
AU  - Ming,DK
AU  - Jangam,S
AU  - Gowers,SAN
AU  - Wilson,R
AU  - Freeman,DME
AU  - Boutelle,MG
AU  - Cass,AEG
AU  - OHare,D
AU  - Holmes,AH
DO  - 10.1136/bmjinnov-2021-000864
EP  - 94
PY  - 2022///
SN  - 2055-8074
SP  - 87
TI  - Real-time continuous measurement of lactate through a minimally invasive microneedle patch: a phase I clinical study
T2  - BMJ Innovations
UR  - http://dx.doi.org/10.1136/bmjinnov-2021-000864
UR  - https://innovations.bmj.com/content/early/2022/02/27/bmjinnov-2021-000864
UR  - http://hdl.handle.net/10044/1/96073
VL  - 8
ER  -
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