Imperial College London
Alternate

ProfessorAlisonHolmes

Faculty of Medicine, Department of Infectious Disease

Professor of Infectious Diseases
 
 
 
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Contact

 

+44 (0)20 3313 1283alison.holmes

 
 
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Location

 

8N16Hammersmith HospitalHammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Flowers:2022:10.1101/2022.06.15.22276423,
author = {Flowers, P and McLeod, J and Mapp, F and Stirrup, O and Blackstone, J and Snell, LB and Peters, C and Thomson, E and Holmes, A and Price, J and Partridge, D and Shallcross, L and de, Silva TI and Breuer, J},
doi = {10.1101/2022.06.15.22276423},
title = {How acceptable is rapid whole genome sequencing for infectious disease management in hospitals? Perspectives of those involved in managing nosocomial SARS-CoV-2},
url = {http://dx.doi.org/10.1101/2022.06.15.22276423},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - <jats:title>Structured summary</jats:title><jats:sec><jats:title>Background</jats:title><jats:p>Whole genome sequencing (WGS) for managing healthcare associated infections (HCAIs) has developed considerably through experiences with SARS-CoV-2. We interviewed various healthcare professionals (HCPs) with direct experience of using WGS in hospitals (within the COG-UK Hospital Onset COVID-19 Infection (HOCI) study) to explore its acceptability and future use.</jats:p></jats:sec><jats:sec><jats:title>Method</jats:title><jats:p>An exploratory, cross-sectional, qualitative design employed semi-structured interviews with 39 diverse HCPs between December 2020 and June 2021. Participants were recruited from five sites within the larger clinical study of a novel genome sequencing reporting tool for SARS-CoV-2 (the HOCI study). All had experience, in their diverse roles, of using sequencing data to manage nosocomial SARS-CoV-2 infection. Deductive and inductive thematic analysis identified themes exploring aspects of the acceptability of sequencing.</jats:p></jats:sec><jats:sec><jats:title>Findings</jats:title><jats:p>The analysis highlighted the overall acceptability of rapid WGS for infectious disease using SARS-CoV-2 as a case study. Diverse professionals were largely very positive about its future use and believed that it could become a valuable and routine tool for managing HCAIs. We identified three key themes ‘1) ‘Proof of concept achieved’; 2) ‘Novel insights and implications’; and 3) ‘Challenges and demands’.</jats:p></jats:sec><jats:sec><jats:title>Conclusion</jats:title><jats:p>Our qualitative analysis, drawn from five diverse hospitals, shows the broad acceptability of rapid sequencing and its potential. Participants believed it could and should become an everyday technology capable
AU  - Flowers,P
AU  - McLeod,J
AU  - Mapp,F
AU  - Stirrup,O
AU  - Blackstone,J
AU  - Snell,LB
AU  - Peters,C
AU  - Thomson,E
AU  - Holmes,A
AU  - Price,J
AU  - Partridge,D
AU  - Shallcross,L
AU  - de,Silva TI
AU  - Breuer,J
DO  - 10.1101/2022.06.15.22276423
PY  - 2022///
TI  - How acceptable is rapid whole genome sequencing for infectious disease management in hospitals? Perspectives of those involved in managing nosocomial SARS-CoV-2
UR  - http://dx.doi.org/10.1101/2022.06.15.22276423
ER  -
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