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@article{Lin:2018:10.1002/ijc.31650,
author = {Lin, C and Travis, RC and Appleby, PN and Tipper, S and Weiderpass, E and Chang-Claude, J and Gram, IT and Kaaks, R and Kiemeney, LA and Ljungberg, B and Tumino, R and Tjønneland, A and Roswall, N and Overvad, K and Boutron-Ruault, M-C and Manciniveri, FR and Severi, G and Trichopoulou, A and Masala, G and Sacerdote, C and Agnoli, C and Panico, S and Bueno-de-Mesquita, B and Peeters, PH and Salamanca-Fernández, E and Chirlaque, M-D and Ardanaz, E and Dorronsoro, M and Menéndez, V and Luján-Barroso, L and Liedberg, F and Freisling, H and Gunter, M and Aune, D and Cross, AJ and Riboli, E and Key, TJ and Perez-Cornago, A},
doi = {10.1002/ijc.31650},
journal = {International Journal of Cancer},
pages = {2351--2358},
title = {Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European prospective investigation into cancer and nutrition},
url = {http://dx.doi.org/10.1002/ijc.31650},
volume = {143},
year = {2018}
}

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TY  - JOUR
AB  - Previous in vitro and case-control studies have found an association between the insulin-like growth factor (IGF)-axis and bladder cancer risk. Circulating concentrations of IGF-I have also been found to be associated with an increased risk of several cancer types; however, the relationship between pre-diagnostic circulating IGF-I concentrations and bladder cancer has never been studied prospectively. We investigated the association of pre-diagnostic plasma concentrations of IGF-I with risk of overall bladder cancer and urothelial cell carcinoma (UCC) in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. A total of 843 men and women diagnosed with bladder cancer between 1992 and 2005 were matched with 843 controls by recruitment centre, sex, age at recruitment, date of blood collection, duration of follow-up, time of day and fasting status at blood collection using an incidence density sampling protocol. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated using conditional logistic regression with adjustment for smoking status. No association was found between pre-diagnostic circulating IGF-I concentration and overall bladder cancer risk (adjusted OR for highest versus lowest fourth: 0.91, 95% CI: 0.66-1.24, Ptrend =0.40) or UCC (n of cases=776; 0.91, 0.65-1.26, Ptrend =0.40). There was no significant evidence of heterogeneity in the association of IGF-I with bladder cancer risk by tumour aggressiveness, sex, smoking status, or by time between blood collection and diagnosis (Pheterogeneity >0.05 for all). This first prospective study indicates no evidence of an association between plasma IGF-I concentrations and bladder cancer risk. This article is protected by copyright. All rights reserved.
AU  - Lin,C
AU  - Travis,RC
AU  - Appleby,PN
AU  - Tipper,S
AU  - Weiderpass,E
AU  - Chang-Claude,J
AU  - Gram,IT
AU  - Kaaks,R
AU  - Kiemeney,LA
AU  - Ljungberg,B
AU  - Tumino,R
AU  - Tjønneland,A
AU  - Roswall,N
AU  - Overvad,K
AU  - Boutron-Ruault,M-C
AU  - Manciniveri,FR
AU  - Severi,G
AU  - Trichopoulou,A
AU  - Masala,G
AU  - Sacerdote,C
AU  - Agnoli,C
AU  - Panico,S
AU  - Bueno-de-Mesquita,B
AU  - Peeters,PH
AU  - Salamanca-Fernández,E
AU  - Chirlaque,M-D
AU  - Ardanaz,E
AU  - Dorronsoro,M
AU  - Menéndez,V
AU  - Luján-Barroso,L
AU  - Liedberg,F
AU  - Freisling,H
AU  - Gunter,M
AU  - Aune,D
AU  - Cross,AJ
AU  - Riboli,E
AU  - Key,TJ
AU  - Perez-Cornago,A
DO  - 10.1002/ijc.31650
EP  - 2358
PY  - 2018///
SN  - 0020-7136
SP  - 2351
TI  - Pre-diagnostic circulating insulin-like growth factor-I and bladder cancer risk in the European prospective investigation into cancer and nutrition
T2  - International Journal of Cancer
UR  - http://dx.doi.org/10.1002/ijc.31650
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29971779
UR  - https://onlinelibrary.wiley.com/doi/full/10.1002/ijc.31650
UR  - http://hdl.handle.net/10044/1/60873
VL  - 143
ER  -

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