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@article{Key:2019:10.1161/CIRCULATIONAHA.118.038813,
author = {Key, TJ and Appleby, PN and Bradbury, KE and Sweeting, M and Wood, A and Johansson, I and Kühn, T and Steur, M and Weiderpass, E and Wennberg, M and Würtz, AML and Agudo, A and Andersson, J and Arriola, L and Boeing, H and Boer, JMA and Bonnet, F and Boutron-Ruault, M-C and Cross, AJ and Ericson, U and Fagherazzi, G and Ferrari, P and Gunter, M and Huerta, JM and Katzke, V and Khaw, K-T and Krogh, V and La, Vecchia C and Matullo, G and Moreno-Iribas, C and Naska, A and Nilsson, LM and Olsen, A and Overvad, K and Palli, D and Panico, S and Molina-Portillo, E and Quirós, JR and Skeie, G and Sluijs, I and Sonestedt, E and Stepien, M and Tjønneland, A and Trichopoulou, A and Tumino, R and Tzoulaki, I and van, der Schouw YT and Verschuren, WMM and Di, Angelantonio E and Langenberg, C and Forouhi, N and Wareham, N and Butterworth, A and Riboli, E and Danesh, J},
doi = {10.1161/CIRCULATIONAHA.118.038813},
journal = {Circulation},
pages = {2835--2845},
title = {Consumption of Meat, Fish, Dairy Products, and Eggs and Risk of Ischemic Heart Disease:A Prospective Study of 7198 Incident Cases Among 409885 Participants in the Pan-European EPIC Cohort},
url = {http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038813},
volume = {139},
year = {2019}
}

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TY  - JOUR
AB  - BACKGROUND: There is uncertainty about the relevance of animal foods to the etiology of ischemic heart disease (IHD). We examined meat, fish, dairy products and eggs and risk for IHD in the pan-European EPIC cohort. METHODS: A prospective study of 409,885 men and women in nine European countries. Diet was assessed using validated questionnaires, calibrated using 24-hour recalls. Lipids and blood pressure were measured in a subsample. During 12.6 years mean follow up, 7198 participants had a myocardial infarction or died from IHD. The relationships of animal foods with risk were examined using Cox regression with adjustment for other animal foods and relevant covariates. RESULTS: The hazard ratio (HR) for IHD was 1.19 (95% CI 1.06-1.33) for a 100 g/d increment in intake of red and processed meat, and this remained significant after excluding the first 4 years of follow-up (HR 1.25 [1.09-1.42]). Risk was inversely associated with intakes of yogurt (HR 0.93 [0.89-0.98] per 100 g/d increment), cheese (HR 0.92 [0.86-0.98] per 30 g/d increment) and eggs (HR 0.93 [0.88-0.99] per 20 g/d increment); the associations with yogurt and eggs were attenuated and non-significant after excluding the first 4 years of follow-up. Risk was not significantly associated with intakes of poultry, fish or milk. In analyses modelling dietary substitutions, replacement of 100 kcal/d from red and processed meat with 100 kcal/d from fatty fish, yogurt, cheese or eggs was associated with approximately 20% lower risk of IHD. Consumption of red and processed meat was positively associated with serum non-HDL cholesterol concentration and systolic blood pressure, and consumption of cheese was inversely associated with serum non-HDL cholesterol. CONCLUSIONS: Risk for IHD was positively associated with consumption of red and processed meat, and inversely associated with consumption of yogurt, cheese and eggs, although the associations with yogurt and eggs may be influenced by reverse causation bias. It
AU  - Key,TJ
AU  - Appleby,PN
AU  - Bradbury,KE
AU  - Sweeting,M
AU  - Wood,A
AU  - Johansson,I
AU  - Kühn,T
AU  - Steur,M
AU  - Weiderpass,E
AU  - Wennberg,M
AU  - Würtz,AML
AU  - Agudo,A
AU  - Andersson,J
AU  - Arriola,L
AU  - Boeing,H
AU  - Boer,JMA
AU  - Bonnet,F
AU  - Boutron-Ruault,M-C
AU  - Cross,AJ
AU  - Ericson,U
AU  - Fagherazzi,G
AU  - Ferrari,P
AU  - Gunter,M
AU  - Huerta,JM
AU  - Katzke,V
AU  - Khaw,K-T
AU  - Krogh,V
AU  - La,Vecchia C
AU  - Matullo,G
AU  - Moreno-Iribas,C
AU  - Naska,A
AU  - Nilsson,LM
AU  - Olsen,A
AU  - Overvad,K
AU  - Palli,D
AU  - Panico,S
AU  - Molina-Portillo,E
AU  - Quirós,JR
AU  - Skeie,G
AU  - Sluijs,I
AU  - Sonestedt,E
AU  - Stepien,M
AU  - Tjønneland,A
AU  - Trichopoulou,A
AU  - Tumino,R
AU  - Tzoulaki,I
AU  - van,der Schouw YT
AU  - Verschuren,WMM
AU  - Di,Angelantonio E
AU  - Langenberg,C
AU  - Forouhi,N
AU  - Wareham,N
AU  - Butterworth,A
AU  - Riboli,E
AU  - Danesh,J
DO  - 10.1161/CIRCULATIONAHA.118.038813
EP  - 2845
PY  - 2019///
SN  - 0009-7322
SP  - 2835
TI  - Consumption of Meat, Fish, Dairy Products, and Eggs and Risk of Ischemic Heart Disease:A Prospective Study of 7198 Incident Cases Among 409885 Participants in the Pan-European EPIC Cohort
T2  - Circulation
UR  - http://dx.doi.org/10.1161/CIRCULATIONAHA.118.038813
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31006335
UR  - http://hdl.handle.net/10044/1/70030
VL  - 139
ER  -

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