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@article{Kühn:2019:jnci/djz166,
author = {Kühn, T and Stepien, M and López-Nogueroles, M and Machado, AD and Sookthai, D and Johnson, T and Roca, M and Hüsing, A and Maldonado, SG and Cross, AJ and Murphy, N and Freisling, H and Rinaldi, S and Scalbert, A and Fedirco, V and Severi, G and Boutron-Ruault, M-C and Mancini, FR and Sowah, SA and Boeing, H and Jakszyn, P and Sánchez, M-J and Merino, S and Colorado-Yohar, S and Barricarte, A and Khaw, KT and Schmidt, JA and Perez-Cornago, A and Trichopoulou, A and Karakatsani, A and Thriskos, P and Palli, D and Agnoli, C and Tumino, R and Sacerdote, C and Panico, S and Bueno-de-Mesquita, B and van, Gils CH and Heath, A and Gunter, MJ and Riboli, E and Lahoz, A and Jenab, M and Kaaks, R},
doi = {jnci/djz166},
journal = {Journal of the National Cancer Institute},
pages = {516--524},
title = {Pre-diagnostic plasma bile acid levels and colon cancer risk: A prospective study},
url = {http://dx.doi.org/10.1093/jnci/djz166},
volume = {112},
year = {2019}
}

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TY  - JOUR
AB  - BACKGROUND: Bile acids have been proposed to promote colon carcinogenesis. However, there are limited prospective data on circulating bile acid levels and colon cancer risk in humans. METHODS: Associations between pre-diagnostic plasma levels of 17 primary, secondary and tertiary bile acid metabolites (conjugated and unconjugated) and colon cancer risk were evaluated in a nested case-control study within the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Bile acid levels were quantified by tandem mass spectrometry in samples from 569 incident colon cancer cases and 569 matched controls. Multivariable logistic regression analyses were used to estimate odds ratios (ORs) for colon cancer risk across quartiles of bile acid concentrations. RESULTS: Positive associations were observed between colon cancer risk and plasma levels of 7 conjugated bile acid metabolites, i.e. primary bile acids glycocholic acid (ORQuartile 4 vs. Quartile 1=2.22,95 % confidence interval[CI]=1.52, 3.26), taurocholic acid (OR = 1.78, 95%CI=1.23, 2.58), glycochenodeoxycholic acid (OR = 1.68, 95%CI=1.13, 2.48), taurochenodeoxycholic acid (OR = 1.62, 95%CI=1.11-2.36), and glycohyocholic acid (OR = 1.65, 95%CI=1.13, 2.40) as well as the secondary bile acids glycodeoxycholic acid (OR = 1.68, 95%CI=1.12, 2.54) and taurodeoxycholic acid (OR = 1.54, 95%CI=1.02, 2.31). By contrast, unconjugated bile acids and tertiary bile acids were not associated with risk. CONCLUSIONS: This prospective study showed that pre-diagnostic levels of certain conjugated primary and secondary bile acids were positively associated with risk of colon cancer. Our findings support experimental data to suggest that a high bile acid load is colon cancer promotive.
AU  - Kühn,T
AU  - Stepien,M
AU  - López-Nogueroles,M
AU  - Machado,AD
AU  - Sookthai,D
AU  - Johnson,T
AU  - Roca,M
AU  - Hüsing,A
AU  - Maldonado,SG
AU  - Cross,AJ
AU  - Murphy,N
AU  - Freisling,H
AU  - Rinaldi,S
AU  - Scalbert,A
AU  - Fedirco,V
AU  - Severi,G
AU  - Boutron-Ruault,M-C
AU  - Mancini,FR
AU  - Sowah,SA
AU  - Boeing,H
AU  - Jakszyn,P
AU  - Sánchez,M-J
AU  - Merino,S
AU  - Colorado-Yohar,S
AU  - Barricarte,A
AU  - Khaw,KT
AU  - Schmidt,JA
AU  - Perez-Cornago,A
AU  - Trichopoulou,A
AU  - Karakatsani,A
AU  - Thriskos,P
AU  - Palli,D
AU  - Agnoli,C
AU  - Tumino,R
AU  - Sacerdote,C
AU  - Panico,S
AU  - Bueno-de-Mesquita,B
AU  - van,Gils CH
AU  - Heath,A
AU  - Gunter,MJ
AU  - Riboli,E
AU  - Lahoz,A
AU  - Jenab,M
AU  - Kaaks,R
DO  - jnci/djz166
EP  - 524
PY  - 2019///
SN  - 0027-8874
SP  - 516
TI  - Pre-diagnostic plasma bile acid levels and colon cancer risk: A prospective study
T2  - Journal of the National Cancer Institute
UR  - http://dx.doi.org/10.1093/jnci/djz166
UR  - https://www.ncbi.nlm.nih.gov/pubmed/31435679
UR  - https://academic.oup.com/jnci/article/112/5/516/5552558
UR  - http://hdl.handle.net/10044/1/74355
VL  - 112
ER  -

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