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@article{Christakoudi:2021:10.1002/ijc.33339,
author = {Christakoudi, S and Pagoni, P and Ferrari, P and Cross, AJ and Tzoulaki, I and Muller, DC and Weiderpass, E and Freisling, H and Murphy, N and Dossus, L and Fortner, RT and Agudo, A and Overvad, K and Perez-Cornago, A and Key, TJ and Brennan, P and Johansson, M and Tjønneland, A and Halkjær, J and Boutron-Ruault, M-C and Artaud, F and Severi, G and Kaaks, R and Schulze, MB and Bergmann, MM and Masala, G and Grioni, S and Simeon, V and Tumino, R and Sacerdote, C and Skeie, G and Rylander, C and Borch, KB and Quirós, JR and Rodriguez-Barranco, M and Chirlaque, M-D and Ardanaz, E and Amiano, P and Drake, I and Stocks, T and Häggström, C and Harlid, S and Ellingjord-Dale, M and Riboli, E and Tsilidis, KK},
doi = {10.1002/ijc.33339},
journal = {International Journal of Cancer},
pages = {1637--1651},
title = {Weight change in middle adulthood and risk of cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort},
url = {http://dx.doi.org/10.1002/ijc.33339},
volume = {148},
year = {2021}
}

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TY  - JOUR
AB  - Obesity is a risk factor for several major cancers. Associations of weight change in middle adulthood with cancer risk, however, are less clear. We examined the association of change in weight and body mass index (BMI) category during middle adulthood with 42 cancers, using multivariable Cox proportional hazards models in the European Prospective Investigation into Cancer and Nutrition cohort. Of 241,323 participants (31% men), 20% lost and 32% gained weight (>0.4 to 5.0 kg/year) during 6.9 years (average). During 8.0 years of follow-up after the second weight assessment, 20,960 incident cancers were ascertained. Independent of baseline BMI, weight gain (per one kg/year increment) was positively associated with cancer of the corpus uteri (hazard ratio HR=1.14; 95% confidence interval: 1.05-1.23). Compared to stable weight (+/-0.4 kg/year), weight gain (>0.4 to 5.0 kg/year) was positively associated with cancers of the gallbladder and bile ducts (HR=1.41; 1.01-1.96), post-menopausal breast (HR=1.08, 1.00-1.16) and thyroid (HR=1.40; 1.04-1.90). Compared to maintaining normal weight, maintaining overweight or obese BMI (World Health Organization categories) was positively associated with most obesity-related cancers. Compared to maintaining the baseline BMI category, weight gain to a higher BMI category was positively associated with cancers of the post-menopausal breast (HR=1.19; 1.06-1.33), ovary (HR=1.40; 1.04-1.91), corpus uteri (HR=1.42; 1.06-1.91), kidney (HR=1.80; 1.20-2.68) and pancreas in men (HR=1.81; 1.11-2.95). Losing weight to a lower BMI category, however, was inversely associated with cancers of the corpus uteri (HR=0.40; 0.23-0.69) and colon (HR=0.69; 0.52-0.92). Our findings support avoiding weight gain and encouraging weight loss in middle adulthood.
AU  - Christakoudi,S
AU  - Pagoni,P
AU  - Ferrari,P
AU  - Cross,AJ
AU  - Tzoulaki,I
AU  - Muller,DC
AU  - Weiderpass,E
AU  - Freisling,H
AU  - Murphy,N
AU  - Dossus,L
AU  - Fortner,RT
AU  - Agudo,A
AU  - Overvad,K
AU  - Perez-Cornago,A
AU  - Key,TJ
AU  - Brennan,P
AU  - Johansson,M
AU  - Tjønneland,A
AU  - Halkjær,J
AU  - Boutron-Ruault,M-C
AU  - Artaud,F
AU  - Severi,G
AU  - Kaaks,R
AU  - Schulze,MB
AU  - Bergmann,MM
AU  - Masala,G
AU  - Grioni,S
AU  - Simeon,V
AU  - Tumino,R
AU  - Sacerdote,C
AU  - Skeie,G
AU  - Rylander,C
AU  - Borch,KB
AU  - Quirós,JR
AU  - Rodriguez-Barranco,M
AU  - Chirlaque,M-D
AU  - Ardanaz,E
AU  - Amiano,P
AU  - Drake,I
AU  - Stocks,T
AU  - Häggström,C
AU  - Harlid,S
AU  - Ellingjord-Dale,M
AU  - Riboli,E
AU  - Tsilidis,KK
DO  - 10.1002/ijc.33339
EP  - 1651
PY  - 2021///
SN  - 0020-7136
SP  - 1637
TI  - Weight change in middle adulthood and risk of cancer in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
T2  - International Journal of Cancer
UR  - http://dx.doi.org/10.1002/ijc.33339
UR  - https://onlinelibrary.wiley.com/doi/10.1002/ijc.33339
UR  - http://hdl.handle.net/10044/1/83631
VL  - 148
ER  -

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