Imperial College London
Portrait Picture

Professor Amanda Cross

Faculty of Medicine, School of Public Health

Professor of Cancer Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3338amanda.cross

 
 
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Assistant

 

Mr Will Kay +44 (0)20 7594 3350

 
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Location

 

Room 1089Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pearson-Stuttard:2021,
author = {Pearson-Stuttard, J and Bennett, J and Cheng, Y and Vamos, E and Cross, A and Ezzati, M and Gregg, E},
journal = {The Lancet Diabetes and Endocrinology},
pages = {165--173},
title = {Trends in predominant causes of death in those with and without diabetes in England from 2001 to 2018},
url = {http://hdl.handle.net/10044/1/86181},
volume = {9},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundThe prevalence of diabetes has increased in the UK and other high-income countries alongside a substantial decline in cardiovascular mortality. Yet data are scarce on how these trends have changed the causes of death in people with diabetes who have traditionally died primarily of vascular causes. We estimated how all-cause mortality and cause-specific mortality in people with diabetes have changed over time, how the composition of the mortality burden has changed, and how this composition compared with that of the non-diabetes population.MethodsIn this epidemiological analysis of primary care records, we identified 313907 individuals with diabetes in the Clinical Practice Research Datalink, a well described primary care database, between 2001 to 2018, and linked these data to UK Office for National Statistics mortality data. We assembled serial cross sections with longitudinal follow-up to generate a mixed prevalence and incidence study population of patients with diabetes. We used discretised Poisson regression models to estimate annual death rates for deaths from all causes and 12 specific causes for men and women with diabetes. We also identified age-matched and sex matched (1:1) individuals without diabetes from the same dataset and estimated mortality rates in this group.FindingsBetween Jan 1, 2001, and Oct 31, 2018, total mortality declined by 32% in men and 31% in women with diagnosed diabetes. Death rates declined from 40·7 deaths per 1000 person-years to 27·8 deaths per 1000 person-years in men and from 42·7 deaths per 1000 person-years to 29·5 deaths per 1000 person-years in women with diagnosed diabetes. We found similar declines in individuals without diabetes, hence the gap in mortality between those with and without diabetes was maintained over the study period. Cause-specific death rates declined in ten of the 12 cause groups, with exceptions in dementia and liver disease, which increased in both populations. Th
AU  - Pearson-Stuttard,J
AU  - Bennett,J
AU  - Cheng,Y
AU  - Vamos,E
AU  - Cross,A
AU  - Ezzati,M
AU  - Gregg,E
EP  - 173
PY  - 2021///
SN  - 2213-8595
SP  - 165
TI  - Trends in predominant causes of death in those with and without diabetes in England from 2001 to 2018
T2  - The Lancet Diabetes and Endocrinology
UR  - http://hdl.handle.net/10044/1/86181
VL  - 9
ER  -
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