Imperial College London
Portrait Picture

Professor Amanda Cross

Faculty of Medicine, School of Public Health

Professor of Cancer Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3338amanda.cross

 
 
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Assistant

 

Mr Will Kay +44 (0)20 7594 3350

 
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Location

 

Room 1089Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Chan:2022:10.1016/j.cgh.2021.06.049,
author = {Chan, SSM and Chen, Y and Casey, K and Olen, O and Ludvigsson, JF and Carbonnel, F and Oldenburg, B and Gunter, MJ and Tjønneland, A and Grip, O and DEFINe-IBD, Investigators and Lochhead, P and Chan, AT and Wolk, A and Khalili, H},
doi = {10.1016/j.cgh.2021.06.049},
journal = {Clinical Gastroenterology and Hepatology},
pages = {1048--1058},
title = {Obesity is associated with increased risk of Crohn's disease, but not ulcerative colitis: a pooled analysis of five prospective cohort studies},
url = {http://dx.doi.org/10.1016/j.cgh.2021.06.049},
volume = {20},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND AND AIMS: It is unclear whether obesity is associated with the development of inflammatory bowel disease despite compelling data from basic science studies. We therefore examined the association between obesity and risk of Crohn's disease (CD) and ulcerative colitis (UC). METHODS: We conducted pooled analyses of 5 prospective cohorts with validated anthropometric measurements for body mass index (BMI) and waist-hip ratio and other lifestyle factors. Diagnoses of CD and UC were confirmed through medical records or ascertained using validated definitions. We used Cox proportional hazards modeling to calculate pooled multivariable-adjusted HRs (aHRs) and 95% confidence intervals (CIs). RESULTS: Among 601,009 participants (age range, 18-98 years) with 10,110,018 person-years of follow-up, we confirmed 563 incident cases of CD and 1047 incident cases of UC. Obesity (baseline BMI ≥30 kg/m2) was associated with an increased risk of CD (pooled aHR, 1.34; 95% CI, 1.05-1.71, I2 = 0%) compared with normal BMI (18.5 to <25 kg/m2). Each 5 kg/m2 increment in baseline BMI was associated with a 16% increase in risk of CD (pooled aHR, 1.16; 95% CI, 1.05-1.22; I2 = 0%). Similarly, with each 5 kg/m2 increment in early adulthood BMI (age, 18-20 years), there was a 22% increase in risk of CD (pooled aHR, 1.22; 95% CI, 1.05-1.40; I2 = 13.6%). An increase in waist-hip ratio was associated with an increased risk of CD that did not reach statistical significance (pooled aHR across quartiles, 1.08; 95% CI, 0.97-1.19; I2 = 0%). No associations were observed between measures of obesity and risk of UC. CONCLUSIONS: In an adult population, obesity as measured by BMI was associated with an increased risk of older-onset CD but not UC.
AU  - Chan,SSM
AU  - Chen,Y
AU  - Casey,K
AU  - Olen,O
AU  - Ludvigsson,JF
AU  - Carbonnel,F
AU  - Oldenburg,B
AU  - Gunter,MJ
AU  - Tjønneland,A
AU  - Grip,O
AU  - DEFINe-IBD,Investigators
AU  - Lochhead,P
AU  - Chan,AT
AU  - Wolk,A
AU  - Khalili,H
DO  - 10.1016/j.cgh.2021.06.049
EP  - 1058
PY  - 2022///
SN  - 1542-3565
SP  - 1048
TI  - Obesity is associated with increased risk of Crohn's disease, but not ulcerative colitis: a pooled analysis of five prospective cohort studies
T2  - Clinical Gastroenterology and Hepatology
UR  - http://dx.doi.org/10.1016/j.cgh.2021.06.049
UR  - https://www.ncbi.nlm.nih.gov/pubmed/34242756
UR  - http://hdl.handle.net/10044/1/92007
VL  - 20
ER  -
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