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@article{Mori:2021:jncics/pkab084,
author = {Mori, N and Keski-Rahkonen, P and Gicquiau, A and Rinaldi, S and Dimou, N and Harlid, S and Harbs, J and Van, Guelpen B and Aune, D and Cross, AJ and Tsilidis, KK and Severi, G and Kvaskoff, M and Fournier, A and Kaaks, R and Fortner, RT and Schulze, MB and Jakszyn, P and Sánchez, M-J and Colorado-Yohar, SM and Ardanaz, E and Travis, R and Watts, EL and Masala, G and Krogh, V and Tumino, R and Sacerdote, C and Panico, S and de-Mesquita, BB and Gram, IT and Waaseth, M and Gunter, MJ and Murphy, N},
doi = {jncics/pkab084},
journal = {JNCI Cancer Spectrum},
pages = {1--10},
title = {Endogenous circulating sex hormone concentrations and colon cancer risk in postmenopausal women: a prospective study and meta-analysis},
url = {http://dx.doi.org/10.1093/jncics/pkab084},
volume = {5},
year = {2021}
}

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TY  - JOUR
AB  - BackgroundObservational studies have consistently reported that postmenopausal hormone therapy use is associated with lower colon cancer risk. However, epidemiological studies examining the associations between circulating concentrations of endogenous estrogens and colorectal cancer have reported inconsistent results.MethodsWe investigated the associations between circulating concentrations of estrone, estradiol, free estradiol, testosterone, free testosterone, androstenedione, dehydroepiandrosterone (DHEA), progesterone, and sex hormone binding globulin (SHBG) with colon cancer risk in a nested case–control study of 1,028 postmenopausal European women (512 colon cancer cases, 516 matched controls) who were non-current users of exogenous hormones at blood collection. Multivariable conditional logistic regression models were used to compute odds ratios (ORs) and 95% confidence intervals (CIs) to evaluate the association between circulating sex hormones and colon cancer risk. We also conducted a dose-response meta-analysis of prospective studies of circulating estrone and estradiol with colorectal, colon, and rectal cancer risk in postmenopausal women. All statistical tests were 2-sided.ResultsIn the multivariable model, a non-statistically significant positive relationship was found between circulating estrone and colon cancer risk (OR per log2-1 unit increment = 1.17, 95%CI = 1.00–1.38; ORquartile4-quartile1 = 1.33, 95%CI = 0.89–1.97, Ptrend = 0.20). Circulating concentrations of estradiol, free estradiol, testosterone, free testosterone, androstenedione, DHEA, progesterone, and SHBG were not associated with colon cancer risk. In the dose-response meta-analysis, no clear evidence of associations were found between circulating estradiol, and estrone concentrations with colorectal, colon, and rectal cancer risk.ConclusionOur observational and meta-analysis results do not support an association between circulating concentrations of endogenous sex horm
AU  - Mori,N
AU  - Keski-Rahkonen,P
AU  - Gicquiau,A
AU  - Rinaldi,S
AU  - Dimou,N
AU  - Harlid,S
AU  - Harbs,J
AU  - Van,Guelpen B
AU  - Aune,D
AU  - Cross,AJ
AU  - Tsilidis,KK
AU  - Severi,G
AU  - Kvaskoff,M
AU  - Fournier,A
AU  - Kaaks,R
AU  - Fortner,RT
AU  - Schulze,MB
AU  - Jakszyn,P
AU  - Sánchez,M-J
AU  - Colorado-Yohar,SM
AU  - Ardanaz,E
AU  - Travis,R
AU  - Watts,EL
AU  - Masala,G
AU  - Krogh,V
AU  - Tumino,R
AU  - Sacerdote,C
AU  - Panico,S
AU  - de-Mesquita,BB
AU  - Gram,IT
AU  - Waaseth,M
AU  - Gunter,MJ
AU  - Murphy,N
DO  - jncics/pkab084
EP  - 10
PY  - 2021///
SN  - 2515-5091
SP  - 1
TI  - Endogenous circulating sex hormone concentrations and colon cancer risk in postmenopausal women: a prospective study and meta-analysis
T2  - JNCI Cancer Spectrum
UR  - http://dx.doi.org/10.1093/jncics/pkab084
UR  - https://academic.oup.com/jncics/advance-article/doi/10.1093/jncics/pkab084/6377340
UR  - http://hdl.handle.net/10044/1/92200
VL  - 5
ER  -

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