Imperial College London
Portrait Picture

Professor Amanda Cross

Faculty of Medicine, School of Public Health

Professor of Cancer Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3338amanda.cross

 
 
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Assistant

 

Mr Will Kay +44 (0)20 7594 3350

 
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Location

 

Room 1089Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Pearson-Stuttard:2022:10.1016/S2213-8587(21)00288-6,
author = {Pearson-Stuttard, J and Cheng, Y and Bennett, J and Zhou, B and Vamos, E and Valabhji, J and Cross, A and Ezzati, M and Gregg, E},
doi = {10.1016/S2213-8587(21)00288-6},
journal = {The Lancet Diabetes and Endocrinology},
pages = {46--57},
title = {Trends in leading causes of hospitalisation among adults with diabetes in England from 2003 to 2018: an epidemiological analysis of linked primary care records},
url = {http://dx.doi.org/10.1016/S2213-8587(21)00288-6},
volume = {10},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BackgroundDiabetes mellitus (DM) leads to a wide range of established vascular and metabolic complications which has resulted in specific prevention programmes being implemented across high-income countries. DM has been associated with increased risk of a broader set of conditions including cancers, liver disease and common infections. We aimed to examine the trends in a broad set of cause-specific hospitalisations in individuals with DM in England from 2003-2018.MethodsWe identified 309,874 individuals with DM in the Clinical Practice Research Datalink, a well described primary care database, linked to Hospital Episode Statistics inpatient data from 2003-2018. We generated a mixed prevalence and incident DM study population through serial cross sections and follow-up over time. We used a discretised Poisson regression model to estimate annual cause-specific hospitalisation rates in men and women with DM across 17 cause groupings. We generated a 1:1 age and sex matched non-DM population to compare findings. FindingsHospitalisation rates were higher for all causes in persons with DM compared to those without throughout the study period. DM itself and Ischaemic Heart Disease (IHD) were the leading causes of excess hospitalisation in 2003, but by 2018, respiratory conditions, cancers and IHD were the most common causes of excess hospitalisation across men and women. Hospitalisation rates declined in almost all traditional DM complication groupings (IHD, stroke, DM, amputations) whilst generally increasing across broader conditions (cancers, infections, respiratory conditions). These differing trends resulted in a diversification in the cause of hospitalisation, such that the traditional DM complications accounted for more than 50% of hospitalisations in 2003, but only approximately 30% in 2018. In contrast, the portion of hospitalisations that broader conditions accounted for increased including respiratory infections being attributable for 12% of hospitalisations in 2
AU  - Pearson-Stuttard,J
AU  - Cheng,Y
AU  - Bennett,J
AU  - Zhou,B
AU  - Vamos,E
AU  - Valabhji,J
AU  - Cross,A
AU  - Ezzati,M
AU  - Gregg,E
DO  - 10.1016/S2213-8587(21)00288-6
EP  - 57
PY  - 2022///
SN  - 2213-8595
SP  - 46
TI  - Trends in leading causes of hospitalisation among adults with diabetes in England from 2003 to 2018: an epidemiological analysis of linked primary care records
T2  - The Lancet Diabetes and Endocrinology
UR  - http://dx.doi.org/10.1016/S2213-8587(21)00288-6
UR  - https://www.sciencedirect.com/science/article/pii/S2213858721002886?via%3Dihub
UR  - http://hdl.handle.net/10044/1/92734
VL  - 10
ER  -
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