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@article{Baker:2021:10.3390/biomedicines9111521,
author = {Baker, JR and Umesh, S and Jenab, M and Schomburg, L and Tjønneland, A and Olsen, A and Boutron-Ruault, M-C and Rothwell, JA and Severi, G and Katzke, V and Johnson, T and Schulze, MB and Masala, G and Agnoli, C and Simeon, V and Tumino, R and Bueno-de-Mesquita, HB and Gram, IT and Skeie, G and Bonet, C and Rodriguez-Barranco, M and Houerta, JM and Gylling, B and Van, Guelpen B and Perez-Cornago, A and Aglago, E and Freisling, H and Weiderpass, E and Cross, AJ and Heath, AK and Hughes, DJ and Fedirko, V},
doi = {10.3390/biomedicines9111521},
journal = {Biomedicines},
pages = {1--15},
title = {Prediagnostic blood selenium status and mortality among patients with colorectal cancer in Western European populations},
url = {http://dx.doi.org/10.3390/biomedicines9111521},
volume = {9},
year = {2021}
}

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TY  - JOUR
AB  - A higher selenium (Se) status has been shown to be associated with lower risk for colorectal cancer (CRC), but the importance of Se in survival after CRC diagnosis is not well studied. The associations of prediagnostic circulating Se status (as indicated by serum Se and selenoprotein P (SELENOP) measurements) with overall and CRC-specific mortality were estimated using multivariable Cox proportional hazards regression among 995 CRC cases (515 deaths, 396 from CRC) in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Se and SELENOP serum concentrations were measured on average 46 months before CRC diagnosis. Median follow-up time was 113 months. Participants with Se concentrations in the highest quintile (≥100 µg/L) had a multivariable-adjusted hazard ratio (HR) of 0.73 (95% CI: 0.52–1.02; Ptrend = 0.06) for CRC-specific mortality and 0.77 (95% CI: 0.57–1.03; Ptrend = 0.04) for overall mortality, compared with the lowest quintile (≤67.5 µg/L). Similarly, participants with SELENOP concentrations in the highest (≥5.07 mg/L) compared with the lowest quintile (≤3.53 mg/L) had HRs of 0.89 (95% CI: 0.64–1.24; Ptrend = 0.39) for CRC-specific mortality and 0.83 (95% CI: 0.62–1.11; Ptrend = 0.17) for overall mortality. Higher prediagnostic exposure to Se within an optimal concentration (100–150 µg/L) might be associated with improved survival among CRC patients, although our results were not statistically significant and additional studies are needed to confirm this potential association. Our findings may stimulate further research on selenium’s role in survival among CRC patients especially among those residing in geographic regions with suboptimal Se availability.
AU  - Baker,JR
AU  - Umesh,S
AU  - Jenab,M
AU  - Schomburg,L
AU  - Tjønneland,A
AU  - Olsen,A
AU  - Boutron-Ruault,M-C
AU  - Rothwell,JA
AU  - Severi,G
AU  - Katzke,V
AU  - Johnson,T
AU  - Schulze,MB
AU  - Masala,G
AU  - Agnoli,C
AU  - Simeon,V
AU  - Tumino,R
AU  - Bueno-de-Mesquita,HB
AU  - Gram,IT
AU  - Skeie,G
AU  - Bonet,C
AU  - Rodriguez-Barranco,M
AU  - Houerta,JM
AU  - Gylling,B
AU  - Van,Guelpen B
AU  - Perez-Cornago,A
AU  - Aglago,E
AU  - Freisling,H
AU  - Weiderpass,E
AU  - Cross,AJ
AU  - Heath,AK
AU  - Hughes,DJ
AU  - Fedirko,V
DO  - 10.3390/biomedicines9111521
EP  - 15
PY  - 2021///
SN  - 2227-9059
SP  - 1
TI  - Prediagnostic blood selenium status and mortality among patients with colorectal cancer in Western European populations
T2  - Biomedicines
UR  - http://dx.doi.org/10.3390/biomedicines9111521
UR  - https://www.mdpi.com/2227-9059/9/11/1521
UR  - http://hdl.handle.net/10044/1/92393
VL  - 9
ER  -

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