Imperial College London
Portrait Picture

Professor Amanda Cross

Faculty of Medicine, School of Public Health

Professor of Cancer Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3338amanda.cross

 
 
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Assistant

 

Mr Will Kay +44 (0)20 7594 3350

 
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Location

 

Room 1089Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cross:2022:10.1055/a-1795-4673,
author = {Cross, AJ and Robbins, EC and Pack, K and Stenson, I and Rutter, MD and Veitch, AM and Saunders, BP and Duffy, SW and Wooldrage, K},
doi = {10.1055/a-1795-4673},
journal = {Endoscopy},
pages = {948--958},
title = {Post-polypectomy surveillance interval and advanced neoplasia detection rates: a multicenter, retrospective cohort study},
url = {http://dx.doi.org/10.1055/a-1795-4673},
volume = {54},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Background Longer post-polypectomy surveillance intervals are associated with increased colorectal neoplasia detection at surveillance in some studies. We investigated this association to inform optimal surveillance intervals.Methods Patients who underwent colonoscopy and post-polypectomy surveillance at 17 UK hospitals were classified as low/high risk by baseline findings. We compared detection rates of advanced adenomas (≥10mm, tubulovillous/villous, high grade dysplasia), high risk findings (HRFs:≥2 serrated polyps/[adenomas] of which≥1 is≥10mm or has [high grade] dysplasia;≥5 serrated polyps/adenomas; or ≥1 nonpedunculated polyp≥20mm), or colorectal cancer (CRC) at surveillance colonoscopy by surveillance interval (<18 months, 2, 3, 4, 5, 6 years). Risk ratios (RRs) were estimated using multivariable regression.Results Of 11214 patients, 7216 (64%) were low risk and 3998 (36%) were high risk. Among low risk patients, advanced adenoma, HRF, and CRC detection rates at first surveillance were 7.8%, 3.7%, and 1.1%, respectively. Advanced adenoma detection increased with increasing surveillance interval, reaching 9.8% with a 6-year interval (P trend <0.001). Among high risk patients, advanced adenoma, HRF, and CRC detection rates at first surveillance were 15.3%, 10.0%, and 1.5%, respectively. Advanced adenoma and CRC detection rates (P trends <0.001) increased with increasing surveillance interval; RRs (95% confidence intervals) for CRC were 1.54 (0.68–3.48), 4.44 (1.95–10.08), and 5.80 (2.51–13.40) with 3-, 4-, and 5-year intervals, respectively, versus an interval of <18 months.Conclusions Metachronous neoplasia was uncommon among low risk patients, even with long surveillance intervals, supporting recommendations for no surveillance in these patients. For high risk patients, a 3-year surveillance interval would ensure timely CRC detection.
AU  - Cross,AJ
AU  - Robbins,EC
AU  - Pack,K
AU  - Stenson,I
AU  - Rutter,MD
AU  - Veitch,AM
AU  - Saunders,BP
AU  - Duffy,SW
AU  - Wooldrage,K
DO  - 10.1055/a-1795-4673
EP  - 958
PY  - 2022///
SN  - 0013-726X
SP  - 948
TI  - Post-polypectomy surveillance interval and advanced neoplasia detection rates: a multicenter, retrospective cohort study
T2  - Endoscopy
UR  - http://dx.doi.org/10.1055/a-1795-4673
UR  - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000780457100001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://www.thieme-connect.de/products/ejournals/abstract/10.1055/a-1795-4673#info
UR  - http://hdl.handle.net/10044/1/97716
VL  - 54
ER  -
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