Imperial College London
Portrait Picture

Professor Amanda Cross

Faculty of Medicine, School of Public Health

Professor of Cancer Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3338amanda.cross

 
 
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Assistant

 

Mr Will Kay +44 (0)20 7594 3350

 
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Location

 

Room 1089Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Lopes:2023:10.1136/gutjnl-2022-328174,
author = {Lopes, EW and Chan, SSM and Song, M and Ludvigsson, JF and Hakansson, N and Lochhead, P and Clark, A and Burke, KE and Ananthakrishnan, AN and Cross, AJ and Palli, D and Bergmann, MM and Richter, JM and Chan, AT and Olen, O and Wolk, A and Khalili, H},
doi = {10.1136/gutjnl-2022-328174},
journal = {Gut},
pages = {1093--1100},
title = {Lifestyle factors for the prevention of inflammatory bowel disease},
url = {http://dx.doi.org/10.1136/gutjnl-2022-328174},
volume = {72},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Objective To estimate the proportion of cases of Crohn’s disease (CD) and ulcerative colitis (UC) that could be prevented by modifiable lifestyle factors.Design In a prospective cohort study of US adults from the Nurses’ Health Study (NHS; n=72 290), NHSII (n=93 909) and Health Professionals Follow-up Study (HPFS; n=41 871), we created modifiable risk scores (MRS; 0–6) for CD and UC based on established lifestyle risk factors, and healthy lifestyle scores (HLS; 0–9) derived from American healthy lifestyle recommendations. We calculated the population attributable risk by comparing the incidence of CD and UC between low-risk (CD-MRS≤1, UC-MRS≤2, HLS≥7) and high-risk groups. We externally validated our findings in three European cohorts: the Swedish Mammography Cohort (n=37 275), Cohort of Swedish Men (n=40 810) and European Prospective Investigation into Cancer and Nutrition (n=404 144).Results Over 5 117 021 person-years of follow-up (NHS, HPFS: 1986–2016; NHSII: 1991–2017), we documented 346 CD and 456 UC cases. Adherence to a low MRS could have prevented 42.9% (95% CI 12.2% to 66.1%) of CD and 44.4% (95% CI 9.0% to 69.8%) of UC cases. Similarly, adherence to a healthy lifestyle could have prevented 61.1% (95% CI 16.8% to 84.9%) of CD and 42.2% (95% CI 1.7% to 70.9%) of UC cases. In our validation cohorts, adherence to a low MRS and healthy lifestyle could have, respectively, prevented 43.9%–51.2% and 48.8%–60.4% of CD cases and 20.6%–27.8% and 46.8%–56.3% of UC cases.Conclusions Across six US and European cohorts, a substantial burden of inflammatory bowel diseases risk may be preventable through lifestyle modification.
AU  - Lopes,EW
AU  - Chan,SSM
AU  - Song,M
AU  - Ludvigsson,JF
AU  - Hakansson,N
AU  - Lochhead,P
AU  - Clark,A
AU  - Burke,KE
AU  - Ananthakrishnan,AN
AU  - Cross,AJ
AU  - Palli,D
AU  - Bergmann,MM
AU  - Richter,JM
AU  - Chan,AT
AU  - Olen,O
AU  - Wolk,A
AU  - Khalili,H
DO  - 10.1136/gutjnl-2022-328174
EP  - 1100
PY  - 2023///
SN  - 0017-5749
SP  - 1093
TI  - Lifestyle factors for the prevention of inflammatory bowel disease
T2  - Gut
UR  - http://dx.doi.org/10.1136/gutjnl-2022-328174
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000904125500001&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=a2bf6146997ec60c407a63945d4e92bb
UR  - https://gut.bmj.com/content/early/2022/11/28/gutjnl-2022-328174
UR  - http://hdl.handle.net/10044/1/107621
VL  - 72
ER  -
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