Imperial College London
Portrait Picture

Professor Amanda Cross

Faculty of Medicine, School of Public Health

Professor of Cancer Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3338amanda.cross

 
 
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Assistant

 

Mr Will Kay +44 (0)20 7594 3350

 
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Location

 

Room 1089Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Karavasiloglou:2023:10.1016/j.ajcnut.2022.10.004,
author = {Karavasiloglou, N and Hughes, DJ and Murphy, N and Schomburg, L and Sun, Q and Seher, V and Rohrmann, S and Weiderpass, E and Tjønneland, A and Olsen, A and Overvad, K and Boutron-Ruault, M-C and Mancini, FR and Mahamat-Saleh, Y and Kaaks, R and Kuhn, T and Schulze, MB and Tumino, R and Panico, S and Masala, G and Pala, V and Sacerdote, C and Derksen, JWG and Skeie, G and Hjartåker, A and Lasheras, C and Agudo, A and Sánchez, M-J and Chirlaque, M-D and Ardanaz, E and Amiano, P and Van, Guelpen B and Gylling, B and Bradbury, KE and Papier, K and Freisling, H and Aglago, EK and Cross, AJ and Riboli, E and Aune, D and Gunter, MJ and Jenab, M},
doi = {10.1016/j.ajcnut.2022.10.004},
journal = {The American Journal of Clinical Nutrition},
pages = {33--45},
title = {Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts},
url = {http://dx.doi.org/10.1016/j.ajcnut.2022.10.004},
volume = {117},
year = {2023}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Higher dietary calcium consumption is associated with lower colorectal cancer (CRC) risk. However, little data are available on the association between circulating calcium concentrations and CRC risk. OBJECTIVES: To explore the association between circulating calcium concentrations and CRC risk using data from 2 large European prospective cohort studies. METHODS: Conditional logistic regression models were used to calculate multivariable-adjusted ORs and 95% CIs in case-control studies nested within the European Prospective Investigation into Cancer and Nutrition (EPIC; n-cases = 947, n-controls = 947) and the UK Biobank (UK-BB; n-cases = 2759, n-controls = 12,021) cohorts. RESULTS: In EPIC, nonalbumin-adjusted total serum calcium (a proxy of free calcium) was not associated with CRC (OR: 0.94; 95% CI: 0.85, 1.03; modeled as continuous variable, per 1 mg/dL increase), colon cancer (OR: 0.93; 95% CI: 0.82, 1.05) or rectal cancer (OR: 1.01; 95% CI: 0.84, 1.20) risk in the multivariable adjusted model. In the UK-BB, serum ionized calcium (free calcium, most active form) was inversely associated with the risk of CRC (OR: 0.85; 95% CI: 0.76, 0.95; per 1 mg/dL) and colon cancer (OR: 0.78; 95% CI: 0.68, 0.90), but not rectal cancer (OR: 1.02; 95% CI: 0.83, 1.24) in multivariable adjusted models. Meta-analysis of EPIC and UK-BB CRC risk estimates showed an inverse risk association for CRC in the multivariable adjusted model (OR: 0.90; 95%CI: 0.84, 0.97). In analyses by quintiles, in both cohorts, higher levels of serum calcium were associated with reduced CRC risk (EPIC: ORQ5vs.Q1: 0.69; 95% CI: 0.47, 1.00; P-trend = 0.03; UK-BB: ORQ5vs.Q1: 0.82; 95% CI: 0.72, 0.94; P-trend < 0.01). Analyses by anatomical subsite showed an inverse cancer risk association in the colon (EPIC: ORQ5vs.Q1: 0.63, 95% CI: 0.39, 1.02; P-trend = 0.05; UK-BB: ORQ5vs.Q1: 0.75; 95% CI: 0.64, 0.88; P-trend < 0.01) but not the rectum. CONCLUSIONS: In UK-BB, higher serum ionized calcium
AU  - Karavasiloglou,N
AU  - Hughes,DJ
AU  - Murphy,N
AU  - Schomburg,L
AU  - Sun,Q
AU  - Seher,V
AU  - Rohrmann,S
AU  - Weiderpass,E
AU  - Tjønneland,A
AU  - Olsen,A
AU  - Overvad,K
AU  - Boutron-Ruault,M-C
AU  - Mancini,FR
AU  - Mahamat-Saleh,Y
AU  - Kaaks,R
AU  - Kuhn,T
AU  - Schulze,MB
AU  - Tumino,R
AU  - Panico,S
AU  - Masala,G
AU  - Pala,V
AU  - Sacerdote,C
AU  - Derksen,JWG
AU  - Skeie,G
AU  - Hjartåker,A
AU  - Lasheras,C
AU  - Agudo,A
AU  - Sánchez,M-J
AU  - Chirlaque,M-D
AU  - Ardanaz,E
AU  - Amiano,P
AU  - Van,Guelpen B
AU  - Gylling,B
AU  - Bradbury,KE
AU  - Papier,K
AU  - Freisling,H
AU  - Aglago,EK
AU  - Cross,AJ
AU  - Riboli,E
AU  - Aune,D
AU  - Gunter,MJ
AU  - Jenab,M
DO  - 10.1016/j.ajcnut.2022.10.004
EP  - 45
PY  - 2023///
SN  - 0002-9165
SP  - 33
TI  - Prediagnostic serum calcium concentrations and risk of colorectal cancer development in 2 large European prospective cohorts
T2  - The American Journal of Clinical Nutrition
UR  - http://dx.doi.org/10.1016/j.ajcnut.2022.10.004
UR  - https://www.ncbi.nlm.nih.gov/pubmed/36789942
UR  - https://www.sciencedirect.com/science/article/pii/S0002916522105071?via%3Dihub
UR  - http://hdl.handle.net/10044/1/102836
VL  - 117
ER  -
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