Imperial College London
Portrait Picture

Professor Amanda Cross

Faculty of Medicine, School of Public Health

Professor of Cancer Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3338amanda.cross

 
 
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Assistant

 

Mr Will Kay +44 (0)20 7594 3350

 
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Location

 

Room 1089Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Brown:2018:10.1177/0969141317698501,
author = {Brown, JP and Wooldrage, K and Wright, S and Nickerson, C and Cross, AJ and Atkin, WS},
doi = {10.1177/0969141317698501},
journal = {Journal of Medical Screening},
pages = {70--75},
title = {High test positivity and low positive predictive value for colorectal cancer of continued faecal occult blood test screening after negative colonoscopy},
url = {http://dx.doi.org/10.1177/0969141317698501},
volume = {25},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - ObjectivesThe English Bowel Cancer Screening Programme (BCSP) offers biennial screening with a guaiac faecal occult blood test (gFOBT) to 60-74 year olds. Participants with a positive gFOBT are referred for follow-up, but many do not have significant findings. These individuals are reinvited for gFOBT screening provided they remain in the eligible age range. We evaluated the performance of repeat screening in this group. MethodsWe analysed data on BCSP participants reinvited to gFOBT screening, either after previous negative gFOBT (n=327,542), or after a positive gFOBT followed by a diagnostic investigation negative for colorectal cancer (CRC) or adenomas requiring surveillance (n=42,280). Outcomes calculated were uptake, test positivity, yield of CRC, and positive predictive value (PPV) of gFOBT for CRC. ResultsAfter a positive gFOBT and a negative diagnostic investigation, gFOBT uptake in the repeat screening round was 82.6%, positivity was 11.3%, CRC yield was 0.172% of participants adequately screened, and the PPV of gFOBT for CRC was 1.7%. For participants with a previous negative gFOBT, in the subsequent screening round uptake was 87.5%, positivity was 1.3%, yield of CRC was 0.112% of those adequately screened, and the PPV of gFOBT for CRC was 9.1%.Conclusion With high positivity and low PPV for CRC, the suitability of routine repeat gFOBT screening in two years among individuals with a previous positive test and a negative diagnostic exam needs to be carefully considered.
AU  - Brown,JP
AU  - Wooldrage,K
AU  - Wright,S
AU  - Nickerson,C
AU  - Cross,AJ
AU  - Atkin,WS
DO  - 10.1177/0969141317698501
EP  - 75
PY  - 2018///
SN  - 1475-5793
SP  - 70
TI  - High test positivity and low positive predictive value for colorectal cancer of continued faecal occult blood test screening after negative colonoscopy
T2  - Journal of Medical Screening
UR  - http://dx.doi.org/10.1177/0969141317698501
UR  - http://hdl.handle.net/10044/1/44758
VL  - 25
ER  -
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