Imperial College London
Portrait Picture

Professor Amanda Cross

Faculty of Medicine, School of Public Health

Professor of Cancer Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3338amanda.cross

 
 
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Assistant

 

Mr Will Kay +44 (0)20 7594 3350

 
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Location

 

Room 1089Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Jacobs:2018:10.1038/s41395-018-0007-x,
author = {Jacobs, ET and Gupta, S and Baron, JA and Cross, AJ and Lieberman, DA and Murphy, G and Martinez, ME},
doi = {10.1038/s41395-018-0007-x},
journal = {American Journal of Gastroenterology},
pages = {899--905},
title = {Family history of colorectal cancer in first-degree relatives and metachronous colorectal adenoma},
url = {http://dx.doi.org/10.1038/s41395-018-0007-x},
volume = {113},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - OBJECTIVESLittle is known about the relationship between having a first-degree relative (FDR) with colorectal cancer (CRC) and risk for metachronous colorectal adenoma (CRA) following polypectomy.METHODSWe pooled data from seven prospective studies of 7697 patients with previously resected CRAs to quantify the relationship between having a FDR with CRC and risk for metachronous adenoma.RESULTSCompared with having no family history of CRC, a positive family history in any FDR was significantly associated with increased odds of developing any metachronous CRA (OR = 1.14; 95% CI = 1.01–1.29). Higher odds of CRA were observed among individuals with an affected mother (OR = 1.27; 95% CI = 1.05–1.53) or sibling (OR = 1.34; 95% CI = 1.11–1.62) as compared with those without, whereas no association was shown for individuals with an affected father. Odds of having a metachronous CRA increased with number of affected FDRs, with ORs (95% CIs) of 1.07 (0.93–1.23) for one relative and 1.39 (1.02–1.91) for two or more. Younger age of diagnosis of a sibling was associated with higher odds of metachronous CRA, with ORs (95% CIs) of 1.66 (1.08–2.56) for diagnosis at <54 years; 1.34 (0.89–2.03) for 55–64 years; and 1.10 (0.70–1.72) for >65 years (p-trend = 0.008). Although limited by sample size, results for advanced metachronous CRA were similar to those for any metachronous CRA.CONCLUSIONSA family history of CRC is related to a modestly increased odds of metachronous CRA. Future research should explore whether having a FDR with CRC, particularly at a young age, should have a role in risk stratification for surveillance colonoscopy.
AU  - Jacobs,ET
AU  - Gupta,S
AU  - Baron,JA
AU  - Cross,AJ
AU  - Lieberman,DA
AU  - Murphy,G
AU  - Martinez,ME
DO  - 10.1038/s41395-018-0007-x
EP  - 905
PY  - 2018///
SN  - 1572-0241
SP  - 899
TI  - Family history of colorectal cancer in first-degree relatives and metachronous colorectal adenoma
T2  - American Journal of Gastroenterology
UR  - http://dx.doi.org/10.1038/s41395-018-0007-x
UR  - http://hdl.handle.net/10044/1/54723
VL  - 113
ER  -
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