Imperial College London
Portrait Picture

Professor Amanda Cross

Faculty of Medicine, School of Public Health

Professor of Cancer Epidemiology
 
 
 
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Contact

 

+44 (0)20 7594 3338amanda.cross

 
 
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Assistant

 

Mr Will Kay +44 (0)20 7594 3350

 
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Location

 

Room 1089Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Morris:2018:10.1038/bjc.2017.496,
author = {Morris, JS and Bradbury, KE and Cross, AJ and Gunter, MJ and Murphy, N},
doi = {10.1038/bjc.2017.496},
journal = {British Journal of Cancer},
pages = {920--929},
title = {Physical activity, sedentary behaviour and colorectal cancer risk in the UK Biobank},
url = {http://dx.doi.org/10.1038/bjc.2017.496},
volume = {118},
year = {2018}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - BACKGROUND: Observational studies have shown that physical activity levels are inversely, and sedentary behaviours are positively, associated with colorectal cancer risk; however, whether these relationships are consistent across anatomical subsites is uncertain. METHODS: We investigated the associations between colorectal cancer and physical activity (metabolic equivalents (METs)-hours per week), and indicators of sedentary behaviour (television watching time and time spent using computers) among 430 584 men and women enroled in the UK Biobank. Multivariable hazard ratios (HRs) and 95% confidence intervals (CI) were estimated using Cox proportional hazards models. RESULTS: After a median follow-up time of 5.6 years, 2391 incident colorectal cancer cases were recorded. High (60-MET-hours per week) vs low (<10-MET-hours per week) total physical activity was associated with a lower colon cancer risk (HR=0.84, 95% CI: 0.72-0.98; p-trend=0.04), with comparable relationships observed for proximal and distal colon tumours, but no association for rectal cancer. Higher levels of television watching time were associated with greater colon cancer risk (HR for 5 h per day vs 1 h per day=1.32, 95% CI: 1.04-1.68; p-trend=0.007). Time spent using computers was not associated with colorectal cancer risk. CONCLUSIONS: Higher levels of physical activity were associated with lower colon cancer risk, with no heterogeneity by colonic subsite. Sedentary behaviour (television watching) was associated with elevated colon cancer risk.British Journal of Cancer advance online publication, 8 March 2018; doi:10.1038/bjc.2017.496 www.bjcancer.com.
AU  - Morris,JS
AU  - Bradbury,KE
AU  - Cross,AJ
AU  - Gunter,MJ
AU  - Murphy,N
DO  - 10.1038/bjc.2017.496
EP  - 929
PY  - 2018///
SN  - 0007-0920
SP  - 920
TI  - Physical activity, sedentary behaviour and colorectal cancer risk in the UK Biobank
T2  - British Journal of Cancer
UR  - http://dx.doi.org/10.1038/bjc.2017.496
UR  - https://www.ncbi.nlm.nih.gov/pubmed/29520109
UR  - http://hdl.handle.net/10044/1/57675
VL  - 118
ER  -
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