Imperial College London

Professor Dame Amanda Fisher

Faculty of MedicineInstitute of Clinical Sciences

Head of the Institute of Clinical Sciences
 
 
 
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Contact

 

amanda.fisher

 
 
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Assistant

 

Ms Alessandra Lisini +44 (0)20 3313 8236

 
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Location

 

CRB (Clinical Research Building)Hammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

124 results found

Tsubouchi T, Fisher AG, 2013, Reprogramming and the Pluripotent Stem Cell Cycle, EPIGENETICS AND DEVELOPMENT, Editors: Heard, Publisher: ELSEVIER ACADEMIC PRESS INC, Pages: 223-241, ISBN: 978-0-12-416027-9

Book chapter

Fisher AG, Brockdorff N, 2012, Epigenetic memory and parliamentary privilege combine to evoke discussions on inheritance, DEVELOPMENT, Vol: 139, Pages: 3891-3896, ISSN: 0950-1991

Journal article

Soza-Ried J, Fisher AG, 2012, Reprogramming somatic cells towards pluripotency by cellular fusion, CURRENT OPINION IN GENETICS & DEVELOPMENT, Vol: 22, Pages: 459-465, ISSN: 0959-437X

Journal article

Merkenschlager M, Seitan V, Tachibana K, Hao B, Fisher AG, Nasmyth K, Krangel M, Merkenschlager Met al., 2012, Cohesin regulates T cell receptor rearrangement and thymocyte differentiation, 1st Biennial Symposium on Regulatory T Cells and T Helper Cells, Publisher: WILEY-BLACKWELL, Pages: 3-3, ISSN: 0019-2805

Conference paper

Seitan V, Tachibana K, Hao B, Fisher AG, Nasmyth K, Krangel M, Merkenschlager Met al., 2011, How cohesin regulates gene expression and differentiation in non-dividing mammalian cells, Annual Congress of the British-Society-for-Immunology, Publisher: WILEY-BLACKWELL, Pages: 21-21, ISSN: 0019-2805

Conference paper

Seitan VC, Hao B, Tachibana-Konwalski K, Lavagnolli T, Mira-Bontenbal H, Brown KE, Teng G, Carroll T, Terry A, Horan K, Marks H, Adams DJ, Schatz DG, Aragon L, Fisher AG, Krangel MS, Nasmyth K, Merkenschlager Met al., 2011, A role for cohesin in T-cell-receptor rearrangement and thymocyte differentiation, NATURE, Vol: 476, Pages: 467-U126, ISSN: 0028-0836

Journal article

Piccolo FM, Pereira CF, Cantone I, Brown K, Tsubouchi T, Soza-Ried J, Merkenschlager M, Fisher AGet al., 2011, Using heterokaryons to understand pluripotency and reprogramming, PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES, Vol: 366, Pages: 2260-2265, ISSN: 0962-8436

Journal article

Fisher CL, Fisher AG, 2011, Chromatin states in pluripotent, differentiated, and reprogrammed cells, CURRENT OPINION IN GENETICS & DEVELOPMENT, Vol: 21, Pages: 140-146, ISSN: 0959-437X

Journal article

Cantone I, Fisher AG, 2011, Unraveling Epigenetic Landscapes: The Enigma of Enhancers, CELL STEM CELL, Vol: 8, Pages: 128-129, ISSN: 1934-5909

Journal article

Landeira D, Fisher AG, 2011, Inactive yet indispensable: the tale of Jarid2, TRENDS IN CELL BIOLOGY, Vol: 21, Pages: 74-80, ISSN: 0962-8924

Journal article

Mazzarella L, Jorgensen HF, Soza-Ried J, Terry AV, Pearson S, Lacaud G, Kouskoff V, Merkenschlager M, Fisher AGet al., 2011, Embryonic stem cell-derived hemangioblasts remain epigenetically plastic and require PRC1 to prevent neural gene expression, BLOOD, Vol: 117, Pages: 83-87, ISSN: 0006-4971

Journal article

Jorgensen HF, Fisher AG, 2010, Can controversies be put to REST?, NATURE, Vol: 467, Pages: E3-E4, ISSN: 0028-0836

Journal article

Liber D, Domaschenz R, Holmqvist P-H, Mazzarella L, Georgiou A, Leleu M, Fisher AG, Labosky PA, Dillon Net al., 2010, Epigenetic Priming of a Pre-B Cell-Specific Enhancer through Binding of Sox2 and Foxd3 at the ESC Stage, CELL STEM CELL, Vol: 7, Pages: 114-126, ISSN: 1934-5909

Journal article

Schnetz MP, Handoko L, Akhtar-Zaidi B, Bartels CF, Pereira CF, Fisher AG, Adams DJ, Flicek P, Crawford GE, LaFramboise T, Tesar P, Wei C-L, Scacheri PCet al., 2010, CHD7 Targets Active Gene Enhancer Elements to Modulate ES Cell- Specific Gene Expression, PLOS GENETICS, Vol: 6, ISSN: 1553-7390

Journal article

Hadjur S, Williams L, Mira H, Fisher AG, Merkenschlager Met al., 2010, Cohesins Contribute to Long-Range Chromosomal cis-Interactions, 11th International Congress on Cleft Lip and Palate and Related Craniofacial Anomalies, Publisher: WILEY-LISS, Pages: 1634-1634, ISSN: 1552-4825

Conference paper

Fisher AG, Merkenschlager M, 2010, Fresh powder on Waddington's slopes, EMBO REPORTS, Vol: 11, Pages: 490-492, ISSN: 1469-221X

Journal article

Kanhere A, Viiri K, Araujo CC, Rasaiyaah J, Bouwman RD, Whyte WA, Pereira CF, Brookes E, Walker K, Bell GW, Pombo A, Fisher AG, Young RA, Jenner RGet al., 2010, Short RNAs Are Transcribed from Repressed Polycomb Target Genes and Interact with Polycomb Repressive Complex-2, MOLECULAR CELL, Vol: 38, Pages: 675-688, ISSN: 1097-2765

Journal article

Landeira D, Sauer S, Poot R, Dvorkina M, Mazzarella L, Jorgensen HF, Pereira CF, Leleu M, Piccolo FM, Spivakov M, Brookes E, Pombo A, Fisher C, Skarnes WC, Snoek T, Bezstarosti K, Demmers J, Klose RJ, Casanova M, Tavares L, Brockdorff N, Merkenschlager M, Fisher AGet al., 2010, Jarid2 is a PRC2 component in embryonic stem cells required for multi-lineage differentiation and recruitment of PRC1 and RNA Polymerase II to developmental regulators, NATURE CELL BIOLOGY, Vol: 12, Pages: 618-U214, ISSN: 1465-7392

Journal article

Pereira CF, Piccolo FM, Tsubouchi T, Sauer S, Ryan NK, Bruno L, Landeira D, Santos J, Banito A, Gil J, Koseki H, Merkenschlager M, Fisher AGet al., 2010, ESCs Require PRC2 to Direct the Successful Reprogramming of Differentiated Cells toward Pluripotency, Cell stem cell, Vol: 6, Pages: 547-556

Stem Cell, 6 (2010) 547-556. doi:10.1016/j.stem.2010.04.013

Journal article

Santos J, Pereira CF, Di-Gregorio A, Spruce T, Alder O, Rodriguez T, Azuara V, Merkenschlager M, Fisher AGet al., 2010, Differences in the epigenetic and reprogramming properties of pluripotent and extra-embryonic stem cells implicate chromatin remodelling as an important early event in the developing mouse embryo, EPIGENETICS & CHROMATIN, Vol: 3, ISSN: 1756-8935

Journal article

Savarese F, Davila A, Nechanitzky R, De La Rosa-Velazquez I, Pereira CF, Engelke R, Takahashi K, Jenuwein T, Kohwi-Shigematsu T, Fisher AG, Grosschedl Ret al., 2009, Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression, GENES & DEVELOPMENT, Vol: 23, Pages: 2625-2638, ISSN: 0890-9369

Journal article

Bruno L, Mazzarella L, Hoogenkamp M, Hertweck A, Cobb BS, Sauer S, Hadjur S, Leleu M, Naoe Y, Telfer JC, Bonifer C, Taniuchi I, Fisher AG, Merkenschlager Met al., 2009, Runx proteins regulate Foxp3 expression, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 206, Pages: 2329-2337, ISSN: 0022-1007

Journal article

Hadjur S, Williams LM, Ryan NK, Cobb BS, Sexton T, Fraser P, Fisher AG, Merkenschlager Met al., 2009, Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus, NATURE, Vol: 460, Pages: 410-U130, ISSN: 0028-0836

Journal article

Caparros M-L, Fisher AG, Merkenschlager M, 2009, Chromosomes and expression mechanisms: life on the edge, CURRENT OPINION IN GENETICS & DEVELOPMENT, Vol: 19, Pages: 97-98, ISSN: 0959-437X

Journal article

Pereira CF, Fisher AG, 2009, Heterokaryon-based reprogramming for pluripotency., Curr Protoc Stem Cell Biol, Vol: Chapter 4, Pages: Unit-4B.1

Embryonic stem (ES) cells have the ability to self-renew, execute multiple lineage paths, and dominantly reprogram differentiated cells upon cell fusion. Here, we describe an approach that reprograms human B lymphocytes toward pluripotency by generating inter-species heterokaryons with mouse ES cells. This induces a human ES-specific gene expression profile, in which the extent and the rapidity of conversion allows us to compare the capacity of different mouse ES cell lines to dominantly induce pluripotency. This approach, coupled with pharmacological inhibition, gene knock-out, or knock-down permits factors that are required to directly induce reprogramming to be defined individually, as well as in combination. Experimental heterokaryons provide a simple and tractable approach to address the mechanisms underlying direct reprogramming to pluripotency. The procedure requires 5 days to complete.

Journal article

Jorgensen HF, Fisher AG, 2009, LOCKing in Cellular Potential, CELL STEM CELL, Vol: 4, Pages: 192-194, ISSN: 1934-5909

Journal article

Jorgensen HF, Terry A, Beretta C, Pereira CF, Leleu M, Chen Z-F, Kelly C, Merkenschlager M, Fisher AGet al., 2009, REST selectively represses a subset of RE1-containing neuronal genes in mouse embryonic stem cells, DEVELOPMENT, Vol: 136, Pages: 715-721, ISSN: 0950-1991

Journal article

Jorgensen HF, Chen Z-F, Merkenschlager M, Fisher AGet al., 2009, Is REST required for ESC pluripotency?, NATURE, Vol: 457, Pages: E4-E5, ISSN: 0028-0836

Journal article

Hadjur S, Bruno L, Hertweck A, Cobb BS, Taylor B, Fisher AG, Merkenschlager Met al., 2009, IL4 blockade of inducible regulatory T cell differentiation: The role of Th2 cells, Gata3 and PU.1, IMMUNOLOGY LETTERS, Vol: 122, Pages: 37-43, ISSN: 0165-2478

Journal article

Taylor B, Cobb BS, Bruno L, Webste Z, Fisher AG, Merkenschlager Met al., 2009, A reappraisal of evidence for probabilistic models of allelic exclusion, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 106, Pages: 516-521, ISSN: 0027-8424

Journal article

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