Imperial College London

Professor Dame Amanda Fisher

Faculty of MedicineInstitute of Clinical Sciences

Head of the Institute of Clinical Sciences
 
 
 
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Contact

 

amanda.fisher

 
 
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Assistant

 

Ms Alessandra Lisini +44 (0)20 3313 8236

 
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Location

 

CRB (Clinical Research Building)Hammersmith Campus

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Summary

 

Publications

Publication Type
Year
to

124 results found

Fisher AG, 2002, Cellular identity and lineage choice, NATURE REVIEWS IMMUNOLOGY, Vol: 2, Pages: 977-982, ISSN: 1474-1733

Journal article

Graf D, Nethisinghe S, Palmer DB, Fisher AG, Merkenschlager Met al., 2002, The developmentally regulated expression of twisted gastrulation reveals a role for bone morphogenetic proteins in the control of T cell development, Journal of Experimental Medicine, Vol: 196, Pages: 163-171, ISSN: 0022-1007

The evolutionarily conserved, secreted protein Twisted gastrulation (Tsg) modulates morphogenetic effects of decapentaplegic (dpp) and its orthologs, the bone morphogenetic proteins 2 and 4 (BMP2/4), in early Drosophila and vertebrate embryos. We have uncovered a role for Tsg at a much later stage of mammalian development, during T cell differentiation in the thymus. BMP4 is expressed by thymic stroma and inhibits the proliferation of CD4(-)CD8(-) double-negative (DN) thymocytes and their differentiation to the CD4(+)CD8(+) double-positive (DP) stage in vitro. Tsg is expressed by thymocytes and up-regulated after T cell receptor signaling at two developmental checkpoints, the transition from the DN to the DP and from the DP to the CD4(+) or CD8(+) single-positive stage. Tsg can synergize with the BMP inhibitor chordin to block the BMP4-mediated inhibition of thymocyte proliferation and differentiation. These data suggest that the developmentally regulated expression of Tsg may allow thymocytes to temporarily withdraw from inhibitory BMP signals.

Journal article

Baxter J, Merkenschlager M, Fisher AG, 2002, Nuclear organisation and gene expression, CURRENT OPINION IN CELL BIOLOGY, Vol: 14, Pages: 372-376, ISSN: 0955-0674

Journal article

Kosak ST, Skok JA, Medina KL, Riblet R, Le Beau MM, Fisher AG, Singh Het al., 2002, Subnuclear compartmentalization of immunoglobulin loci during lymphocyte development, SCIENCE, Vol: 296, Pages: 158-162, ISSN: 0036-8075

Journal article

Fisher AG, Merkenschlager M, 2002, Gene silencing, cell fate and nuclear organisation, CURRENT OPINION IN GENETICS & DEVELOPMENT, Vol: 12, Pages: 193-197, ISSN: 0959-437X

Journal article

Smale ST, Fisher AG, 2002, Chromatin structure and gene regulation in the immune system, ANNUAL REVIEW OF IMMUNOLOGY, Vol: 20, Pages: 427-462, ISSN: 0732-0582

Journal article

Smith K, Seddon B, Purbhoo MA, Zamoyska R, Fisher AG, Merkenslchlager Met al., 2001, Sensory adaptation in naive peripheral CD4 T cells, Journal of Experimental Medicine, Vol: 194, Pages: 1253-1261, ISSN: 1540-9538

T cell receptor interactions with peptide/major histocompatibility complex (pMHC) ligandscontrol the selection of T cells in the thymus as well as their homeostasis in peripheral lymphoidorgans. Here we show that pMHC contact modulates the expression of CD5 by naiveCD4 T cells in a process that requires the continued expression of p56lck. Reduced CD5 levelsin T cells deprived of pMHC contact are predictive of elevated Ca2 responses to subsequentTCR engagement by anti-CD3 or nominal antigen. Adaptation to peripheral pMHC contactmay be important for regulating naive CD4 T cell responsiveness.

Journal article

Skok JA, Brown KE, Azuara V, Caparros ML, Baxter J, Takacs K, Dillon N, Gray D, Perry RP, Merkenschlager M, Fisher AGet al., 2001, Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes, NATURE IMMUNOLOGY, Vol: 2, Pages: 848-854, ISSN: 1529-2908

Journal article

Graf D, Timmons PM, Hitchins M, Episkopou V, Moore G, Ito T, Fujiyama A, Fisher AG, Merkenschlager Met al., 2001, Evolutionary conservation, developmental expression, and genomic mapping of mammalian Twisted gastrulation, MAMMALIAN GENOME, Vol: 12, Pages: 554-560, ISSN: 0938-8990

Journal article

Graf D, Timmons PM, Hitchins M, Episkopou V, Moore G, Ito T, Fujiyama A, Fisher AG, Merkenschlager Met al., 2001, Evolutionary conservation, developmental expression, and genomic mapping of mammalian, Mammalian Genome, Vol: 012, Pages: 0554-0560, ISSN: 0938-8990

Journal article

Brown KE, Amoils S, Horn JM, Buckle VJ, Higgs DR, Merkenschlager M, Fisher AGet al., 2001, Expression of alpha- and beta-globin genes occurs within different nuclear domains in haemopoietic cells, NATURE CELL BIOLOGY, Vol: 3, Pages: 602-606, ISSN: 1465-7392

Journal article

Cobb BS, Morales-Alcelay S, Kleiger G, Brown KE, Fisher AG, Smale STet al., 2000, Targeting of Ikaros to pericentromeric heterochromatin by direct DNA binding, GENES & DEVELOPMENT, Vol: 14, Pages: 2146-2160, ISSN: 0890-9369

Journal article

Lovatt M, Yang TH, Stauss HJ, Fisher AG, Merkenschlager Met al., 2000, Different doses of agonistic ligand drive the maturation of functional CD4 and CD8 T cells from immature precursors, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 30, Pages: 371-381, ISSN: 0014-2980

Journal article

Brown KE, Baxter J, Graf D, Merkenschlager M, Fisher AGet al., 1999, Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division, MOLECULAR CELL, Vol: 3, Pages: 207-217, ISSN: 1097-2765

Journal article

Ernst P, Hahm K, Cobb BS, Brown KE, Trinh LA, McCarty AS, Merkenschlager M, Klug CA, Fisher AG, Smale STet al., 1999, Mechanisms of transcriptional regulation in lymphocyte progenitors: Insight from an analysis of the terminal transferase promoter, COLD SPRING HARBOR SYMPOSIA ON QUANTITATIVE BIOLOGY, Vol: 64, Pages: 87-97, ISSN: 0091-7451

Journal article

Hahm K, Cobb BS, McCarty AS, Brown KE, Klug CA, Lee R, Akashi K, Weissman IL, Fisher AG, Smale STet al., 1998, Helios, a T cell-restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin, GENES & DEVELOPMENT, Vol: 12, Pages: 782-796, ISSN: 0890-9369

Journal article

Brown KE, Guest SS, Smale ST, Hahm K, Merkenschlager M, Fisher AGet al., 1997, Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin, CELL, Vol: 91, Pages: 845-854, ISSN: 0092-8674

Journal article

Merkenschlager M, Graf D, Lovatt M, Bommhardt U, Zamoyska R, Fisher AGet al., 1997, How many thymocytes audition for selection?, JOURNAL OF EXPERIMENTAL MEDICINE, Vol: 186, Pages: 1149-1158, ISSN: 0022-1007

Journal article

Graf D, Fisher AG, Merkenschlager M, 1997, Rational primer design greatly improves differential display PCR (DD-PCR), NUCLEIC ACIDS RESEARCH, Vol: 25, Pages: 2239-2240, ISSN: 0305-1048

Journal article

FISHER AG, BURDET C, BUNCE C, MERKENSCHLAGER M, CEREDIG Ret al., 1995, LYMPHOPROLIFERATIVE DISORDERS IN IL-7 TRANSGENIC MICE - EXPANSION OF IMMATURE B-CELLS WHICH RETAIN MACROPHAGE POTENTIAL, INTERNATIONAL IMMUNOLOGY, Vol: 7, Pages: 415-423, ISSN: 0953-8178

Journal article

LOMBARDPLATET S, FISHER AG, MEYER V, CEREDIG Ret al., 1995, EXPRESSION OF FUNCTIONAL MHC CLASS-II MOLECULES BY A MOUSE PRO-B CELL CLONE, DEVELOPMENTAL IMMUNOLOGY, Vol: 4, Pages: 85-92, ISSN: 1044-6672

Journal article

FISHER AG, WALTZINGER C, CEREDIG R, 1992, SELECTION OF MURINE T-CELL RECEPTOR ALPHA-BETA AND GAMMA-DELTA CELLS IN ORGAN-CULTURES ESTABLISHED FROM 14-DAY EMBRYOS, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 22, Pages: 1765-1771, ISSN: 0014-2980

Journal article

LARSSON L, HICKS R, FISHER AG, 1992, IDENTIFICATION OF MURINE THYMOCYTE POPULATIONS CAPABLE OF EXTENSIVE PROLIFERATION IN SERIALLY PASSAGED THYMIC ORGAN-CULTURES, THYMUS, Vol: 19, Pages: 193-206, ISSN: 0165-6090

Journal article

MERKENSCHLAGER M, FISHER AG, 1992, SELECTIVE MANIPULATION OF THE HUMAN T-CELL RECEPTOR REPERTOIRE EXPRESSED BY THYMOCYTES IN ORGAN-CULTURE, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, Vol: 89, Pages: 4255-4259, ISSN: 0027-8424

Journal article

MERKENSCHLAGER M, FISHER AG, 1992, HUMAN POSTNATAL THYMOCYTES GENERATE PHENOTYPICALLY IMMATURE CD3DIM, CD5DIM, CD1ABRIGHT PROGENY IN ORGAN-CULTURE, JOURNAL OF IMMUNOLOGY, Vol: 148, Pages: 1012-1015, ISSN: 0022-1767

Journal article

FISHER AG, CEREDIG R, 1991, GAMMA-DELTA-T-CELLS EXPRESSING CD8 OR CD4LOW APPEAR EARLY IN MURINE FETAL THYMUS DEVELOPMENT, INTERNATIONAL IMMUNOLOGY, Vol: 3, Pages: 1323-1328, ISSN: 0953-8178

Journal article

DANIELS RS, SMITH MH, FISHER AG, 1991, MOLECULAR CHARACTERIZATION OF BIOLOGICALLY DIVERSE ENVELOPE VARIANTS OF HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 DERIVED FROM AN INDIVIDUAL, JOURNAL OF VIROLOGY, Vol: 65, Pages: 5574-5578, ISSN: 0022-538X

Journal article

MERKENSCHLAGER M, IKEDA H, WILKINSON D, BEVERLEY PCL, TROWSDALE J, FISHER AG, ALTMANN DMet al., 1991, ALLORECOGNITION OF HLA-DR AND HLA-DQ TRANSFECTANTS BY HUMAN CD45RA AND CD45R0 CD4 T-CELLS - REPERTOIRE ANALYSIS AND ACTIVATION REQUIREMENTS, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 21, Pages: 79-88, ISSN: 0014-2980

Journal article

MERKENSCHLAGER M, FISHER AG, 1991, CD45 ISOFORM SWITCHING PRECEDES THE ACTIVATION-DRIVEN DEATH OF HUMAN THYMOCYTES BY APOPTOSIS, INTERNATIONAL IMMUNOLOGY, Vol: 3, Pages: 1-7, ISSN: 0953-8178

Journal article

GOFF LK, LARSSON L, FISHER AG, 1990, EXPRESSION OF HIGH-MOLECULAR-WEIGHT ISOFORMS OF CD45 BY MOUSE THYMIC PROGENITOR CELLS, EUROPEAN JOURNAL OF IMMUNOLOGY, Vol: 20, Pages: 665-671, ISSN: 0014-2980

Journal article

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