122 results found
FISHER AG, GOFF LK, LIGHTSTONE L, et al., 1989, PROBLEMS IN THE PHYSIOLOGY OF CLASS-I AND CLASS-II MHC MOLECULES, AND OF CD45, 3RD SYMP ON IMMUNOLOGICAL RECOGNITION, Publisher: COLD SPRING HARBOR LABORATORY PRESS, Pages: 667-674
Fisher AG, Goff LK, Lightstone L, et al., 1989, Problems in the physiology of class I and class II MHC molecules, and of CD45., Cold Spring Harb Symp Quant Biol, Vol: 54 Pt 2, Pages: 667-674, ISSN: 0091-7451
1. Co-processing of alloantigens suggests that epitope-loaded MHC class I molecules may pass from tissue cells to dendritic cells. 2. Antigen-presenting cells in the thymus need some special trick in order to load their MHC class II molecules with epitopes from "intermediate concentration" self-proteins in order to induce self-tolerance in developing cells. 3. Cell-cell interactions may transmit signals simply by rearranging surface glycoproteins and thus locally perturbing a phosphorylation equilibrium. 4. The CD45 and STB1 phenotype of most cells in the thymus may be characteristic of a doomed cell.
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