Imperial College London

Professor DameMandyFisher

Faculty of MedicineInstitute of Clinical Sciences

Head of the Institute of Clinical Sciences



+44 (0)20 3313 8236amanda.fisher




Ms Alessandra Lisini +44 (0)20 3313 8236




CRB (Clinical Research Building)Hammersmith Campus





Publication Type

121 results found

Fisher AG, Goff LK, Lightstone L, Marvel J, Mitchison NA, Poirier G, Stauss H, Zamoyska Ret al., 1989, Problems in the physiology of class I and class II MHC molecules, and of CD45., Cold Spring Harb Symp Quant Biol, Vol: 54 Pt 2, Pages: 667-674, ISSN: 0091-7451

1. Co-processing of alloantigens suggests that epitope-loaded MHC class I molecules may pass from tissue cells to dendritic cells. 2. Antigen-presenting cells in the thymus need some special trick in order to load their MHC class II molecules with epitopes from "intermediate concentration" self-proteins in order to induce self-tolerance in developing cells. 3. Cell-cell interactions may transmit signals simply by rearranging surface glycoproteins and thus locally perturbing a phosphorylation equilibrium. 4. The CD45 and STB1 phenotype of most cells in the thymus may be characteristic of a doomed cell.


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