Imperial College London

Professor DameMandyFisher

Faculty of MedicineInstitute of Clinical Sciences

Head of the Institute of Clinical Sciences



+44 (0)20 3313 8236amanda.fisher




Ms Alessandra Lisini +44 (0)20 3313 8236




CRB (Clinical Research Building)Hammersmith Campus






BibTex format

author = {Smith, K and Seddon, B and Purbhoo, MA and Zamoyska, R and Fisher, AG and Merkenslchlager, M},
doi = {10.1084/jem.194.9.1253},
journal = {Journal of Experimental Medicine},
pages = {1253--1261},
title = {Sensory adaptation in naive peripheral CD4 T cells},
url = {},
volume = {194},
year = {2001}

RIS format (EndNote, RefMan)

AB - T cell receptor interactions with peptide/major histocompatibility complex (pMHC) ligandscontrol the selection of T cells in the thymus as well as their homeostasis in peripheral lymphoidorgans. Here we show that pMHC contact modulates the expression of CD5 by naiveCD4 T cells in a process that requires the continued expression of p56lck. Reduced CD5 levelsin T cells deprived of pMHC contact are predictive of elevated Ca2 responses to subsequentTCR engagement by anti-CD3 or nominal antigen. Adaptation to peripheral pMHC contactmay be important for regulating naive CD4 T cell responsiveness.
AU - Smith,K
AU - Seddon,B
AU - Purbhoo,MA
AU - Zamoyska,R
AU - Fisher,AG
AU - Merkenslchlager,M
DO - 10.1084/jem.194.9.1253
EP - 1261
PY - 2001///
SN - 1540-9538
SP - 1253
TI - Sensory adaptation in naive peripheral CD4 T cells
T2 - Journal of Experimental Medicine
UR -
UR -
UR -
VL - 194
ER -