Imperial College London

Professor DameMandyFisher

Faculty of MedicineInstitute of Clinical Sciences

Head of the Institute of Clinical Sciences
 
 
 
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Contact

 

+44 (0)20 3313 8236amanda.fisher

 
 
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Assistant

 

Ms Alessandra Lisini +44 (0)20 3313 8236

 
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Location

 

CRB (Clinical Research Building)Hammersmith Campus

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Summary

 

Publications

Citation

BibTex format

@article{Smith:2001:10.1084/jem.194.9.1253,
author = {Smith, K and Seddon, B and Purbhoo, MA and Zamoyska, R and Fisher, AG and Merkenslchlager, M},
doi = {10.1084/jem.194.9.1253},
journal = {Journal of Experimental Medicine},
pages = {1253--1261},
title = {Sensory adaptation in naive peripheral CD4 T cells},
url = {http://dx.doi.org/10.1084/jem.194.9.1253},
volume = {194},
year = {2001}
}

RIS format (EndNote, RefMan)

TY  - JOUR
AB - T cell receptor interactions with peptide/major histocompatibility complex (pMHC) ligandscontrol the selection of T cells in the thymus as well as their homeostasis in peripheral lymphoidorgans. Here we show that pMHC contact modulates the expression of CD5 by naiveCD4 T cells in a process that requires the continued expression of p56lck. Reduced CD5 levelsin T cells deprived of pMHC contact are predictive of elevated Ca2 responses to subsequentTCR engagement by anti-CD3 or nominal antigen. Adaptation to peripheral pMHC contactmay be important for regulating naive CD4 T cell responsiveness.
AU - Smith,K
AU - Seddon,B
AU - Purbhoo,MA
AU - Zamoyska,R
AU - Fisher,AG
AU - Merkenslchlager,M
DO - 10.1084/jem.194.9.1253
EP - 1261
PY - 2001///
SN - 1540-9538
SP - 1253
TI - Sensory adaptation in naive peripheral CD4 T cells
T2 - Journal of Experimental Medicine
UR - http://dx.doi.org/10.1084/jem.194.9.1253
UR - http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000172159500007&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR - http://hdl.handle.net/10044/1/31081
VL - 194
ER -