Imperial College London

Professor DameMandyFisher

Faculty of MedicineInstitute of Clinical Sciences

Head of the Institute of Clinical Sciences



+44 (0)20 3313 8236amanda.fisher




Ms Alessandra Lisini +44 (0)20 3313 8236




CRB (Clinical Research Building)Hammersmith Campus






BibTex format

author = {Fisher, AG and Goff, LK and Lightstone, L and Marvel, J and Mitchison, NA and Poirier, G and Stauss, H and Zamoyska, R},
journal = {Cold Spring Harb Symp Quant Biol},
pages = {667--674},
title = {Problems in the physiology of class I and class II MHC molecules, and of CD45.},
url = {},
volume = {54 Pt 2},
year = {1989}

RIS format (EndNote, RefMan)

AB - 1. Co-processing of alloantigens suggests that epitope-loaded MHC class I molecules may pass from tissue cells to dendritic cells. 2. Antigen-presenting cells in the thymus need some special trick in order to load their MHC class II molecules with epitopes from "intermediate concentration" self-proteins in order to induce self-tolerance in developing cells. 3. Cell-cell interactions may transmit signals simply by rearranging surface glycoproteins and thus locally perturbing a phosphorylation equilibrium. 4. The CD45 and STB1 phenotype of most cells in the thymus may be characteristic of a doomed cell.
AU - Fisher,AG
AU - Goff,LK
AU - Lightstone,L
AU - Marvel,J
AU - Mitchison,NA
AU - Poirier,G
AU - Stauss,H
AU - Zamoyska,R
EP - 674
PY - 1989///
SN - 0091-7451
SP - 667
TI - Problems in the physiology of class I and class II MHC molecules, and of CD45.
T2 - Cold Spring Harb Symp Quant Biol
UR -
VL - 54 Pt 2
ER -