Imperial College London
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Dr Ana Luisa Neves

Faculty of Medicine, School of Public Health

Clinical Senior Lecturer in Digital Health
 
 
 
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Contact

 

ana.luisa.neves14

 
 
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Location

 

Queen Elizabeth the Queen Mother Wing (QEQM)St Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Rodriguez-Martinez:2017:10.1021/acs.analchem.7b02374,
author = {Rodriguez-Martinez, A and Posma, JM and Ayala, R and Harvey, N and Jimenez, B and Neves, AL and Lindon, JC and Sonomura, K and Sato, T-A and Matsuda, F and Zalloua, P and Gauguier, D and Nicholson, JK and Dumas, M-E},
doi = {10.1021/acs.analchem.7b02374},
journal = {Analytical Chemistry},
pages = {11405--11412},
title = {J-Resolved (1)H NMR 1D-Projections for Large-Scale Metabolic Phenotyping Studies: Application to Blood Plasma Analysis.},
url = {http://dx.doi.org/10.1021/acs.analchem.7b02374},
volume = {89},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - (1)H nuclear magnetic resonance (NMR) spectroscopy-based metabolic phenotyping is now widely used for large-scale epidemiological applications. To minimize signal overlap present in 1D (1)H NMR spectra, we have investigated the use of 2D J-resolved (JRES) (1)H NMR spectroscopy for large-scale phenotyping studies. In particular, we have evaluated the use of the 1D projections of the 2D JRES spectra (pJRES), which provide single peaks for each of the J-coupled multiplets, using 705 human plasma samples from the FGENTCARD cohort. On the basis of the assessment of several objective analytical criteria (spectral dispersion, attenuation of macromolecular signals, cross-spectral correlation with GC-MS metabolites, analytical reproducibility and biomarker discovery potential), we concluded that the pJRES approach exhibits suitable properties for implementation in large-scale molecular epidemiology workflows.
AU  - Rodriguez-Martinez,A
AU  - Posma,JM
AU  - Ayala,R
AU  - Harvey,N
AU  - Jimenez,B
AU  - Neves,AL
AU  - Lindon,JC
AU  - Sonomura,K
AU  - Sato,T-A
AU  - Matsuda,F
AU  - Zalloua,P
AU  - Gauguier,D
AU  - Nicholson,JK
AU  - Dumas,M-E
DO  - 10.1021/acs.analchem.7b02374
EP  - 11412
PY  - 2017///
SN  - 0003-2700
SP  - 11405
TI  - J-Resolved (1)H NMR 1D-Projections for Large-Scale Metabolic Phenotyping Studies: Application to Blood Plasma Analysis.
T2  - Analytical Chemistry
UR  - http://dx.doi.org/10.1021/acs.analchem.7b02374
UR  - https://www.ncbi.nlm.nih.gov/pubmed/28937204
UR  - http://hdl.handle.net/10044/1/53467
VL  - 89
ER  -
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