Imperial College London
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Professor Anand Devaraj

Faculty of Medicine, National Heart & Lung Institute

Professor of Practice (Thoracic Radiology)
 
 
 
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Contact

 

anand.devaraj Website

 
 
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Location

 

South BlockRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Vass:2021:10.1183/23120541.00699-2020,
author = {Vass, L and Fisk, M and Cheriyan, J and Mohan, D and Forman, J and Oseni, A and Devaraj, A and Maki-Petaja, KM and McEniery, CM and Fuld, J and Hopkinson, NS and Lomas, DA and Cockcroft, JR and Tal-Singer, R and Polkey, M and Wilkinson, IB},
doi = {10.1183/23120541.00699-2020},
journal = {ERJ Open Research},
pages = {1--12},
title = {Quantitative F-18-fluorodeoxyglucose positron emission tomography/computed tomography to assess pulmonary inflammation in COPD},
url = {http://dx.doi.org/10.1183/23120541.00699-2020},
volume = {7},
year = {2021}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Rationale COPD and smoking are characterised by pulmonary inflammation. 18F-fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) imaging may improve knowledge of pulmonary inflammation in COPD patients and aid early development of novel therapies as an imaging biomarker.Objectives To evaluate pulmonary inflammation, assessed by FDG uptake, in whole and regional lung in “usual” (smoking-related) COPD patients, alpha-1 antitrypsin deficiency (α1ATD) COPD patients, smokers without COPD and never-smokers using FDG PET/CT. Secondly, to explore cross-sectional associations between FDG PET/CT and systemic inflammatory markers in COPD patients and repeatability of the technique in COPD patients.Methods Data from two imaging studies were evaluated. Pulmonary FDG uptake (normalised Ki; nKi) was measured by Patlak graphical analysis in four subject groups: 84 COPD patients, 11 α1ATD-COPD patients, 12 smokers and 10 never-smokers. Within the COPD group, associations between nKi and systemic markers of inflammation were assessed. Repeatability was evaluated in 32 COPD patients comparing nKi values at baseline and at 4-month follow-up.Results COPD patients, α1ATD-COPD patients and smokers had increased whole lung FDG uptake (nKi) compared with never-smokers (0.0037±0.001, 0.0040±0.001, 0.0040±0.001 versus 0.0028±0.001 mL·cm−3·min−1, respectively, p<0.05 for all). Similar results were observed in upper and middle lung regions. In COPD participants, plasma fibrinogen was associated with whole lung nKi (β=0.30, p=0.02) in multivariate analysis adjusted for current smoking, forced expiratory volume in 1s % predicted, systemic neutrophils and C-reactive protein levels. Mean percentage difference in nKi between the baseline and follow-up was 3.2%, and the within subject coefficient of variability was 7.7%.Conclusions FDG PET/CT has potential as a noninvasive tool to
AU  - Vass,L
AU  - Fisk,M
AU  - Cheriyan,J
AU  - Mohan,D
AU  - Forman,J
AU  - Oseni,A
AU  - Devaraj,A
AU  - Maki-Petaja,KM
AU  - McEniery,CM
AU  - Fuld,J
AU  - Hopkinson,NS
AU  - Lomas,DA
AU  - Cockcroft,JR
AU  - Tal-Singer,R
AU  - Polkey,M
AU  - Wilkinson,IB
DO  - 10.1183/23120541.00699-2020
EP  - 12
PY  - 2021///
SN  - 2312-0541
SP  - 1
TI  - Quantitative F-18-fluorodeoxyglucose positron emission tomography/computed tomography to assess pulmonary inflammation in COPD
T2  - ERJ Open Research
UR  - http://dx.doi.org/10.1183/23120541.00699-2020
UR  - https://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000696250500040&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=1ba7043ffcc86c417c072aa74d649202
UR  - https://openres.ersjournals.com/content/7/3/00699-2020
UR  - http://hdl.handle.net/10044/1/100855
VL  - 7
ER  -
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