Imperial College London
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Professor Anand Devaraj

Faculty of Medicine, National Heart & Lung Institute

Professor of Practice (Thoracic Radiology)
 
 
 
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Contact

 

anand.devaraj Website

 
 
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Location

 

South BlockRoyal Brompton Campus

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Summary

 

Publications

Citation

BibTex format

@article{Wu:2022:10.1038/s43018-022-00376-z,
author = {Wu, Y and Biswas, D and Usaite, I and Angelova, M and Boeing, S and Karasaki, T and Veeriah, S and Czyzewska-Khan, J and Morton, C and Joseph, M and Hessey, S and Reading, J and Georgiou, A and Al-Bakir, M and TRACERx, Consortium and McGranahan, N and Jamal-Hanjani, M and Hackshaw, A and Quezada, SA and Hayday, AC and Swanton, C},
doi = {10.1038/s43018-022-00376-z},
journal = {Nat Cancer},
pages = {696--709},
title = {A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer.},
url = {http://dx.doi.org/10.1038/s43018-022-00376-z},
volume = {3},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Murine tissues harbor signature γδ T cell compartments with profound yet differential impacts on carcinogenesis. Conversely, human tissue-resident γδ cells are less well defined. In the present study, we show that human lung tissues harbor a resident Vδ1 γδ T cell population. Moreover, we demonstrate that Vδ1 T cells with resident memory and effector memory phenotypes were enriched in lung tumors compared with nontumor lung tissues. Intratumoral Vδ1 T cells possessed stem-like features and were skewed toward cytolysis and helper T cell type 1 function, akin to intratumoral natural killer and CD8+ T cells considered beneficial to the patient. Indeed, ongoing remission post-surgery was significantly associated with the numbers of CD45RA-CD27- effector memory Vδ1 T cells in tumors and, most strikingly, with the numbers of CD103+ tissue-resident Vδ1 T cells in nonmalignant lung tissues. Our findings offer basic insights into human body surface immunology that collectively support integrating Vδ1 T cell biology into immunotherapeutic strategies for nonsmall cell lung cancer.
AU  - Wu,Y
AU  - Biswas,D
AU  - Usaite,I
AU  - Angelova,M
AU  - Boeing,S
AU  - Karasaki,T
AU  - Veeriah,S
AU  - Czyzewska-Khan,J
AU  - Morton,C
AU  - Joseph,M
AU  - Hessey,S
AU  - Reading,J
AU  - Georgiou,A
AU  - Al-Bakir,M
AU  - TRACERx,Consortium
AU  - McGranahan,N
AU  - Jamal-Hanjani,M
AU  - Hackshaw,A
AU  - Quezada,SA
AU  - Hayday,AC
AU  - Swanton,C
DO  - 10.1038/s43018-022-00376-z
EP  - 709
PY  - 2022///
SP  - 696
TI  - A local human Vδ1 T cell population is associated with survival in nonsmall-cell lung cancer.
T2  - Nat Cancer
UR  - http://dx.doi.org/10.1038/s43018-022-00376-z
UR  - https://www.ncbi.nlm.nih.gov/pubmed/35637401
VL  - 3
ER  -
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