Imperial College London
ANAT MELAMED

ANAT MELAMED

Faculty of Medicine, Department of Infectious Disease

Research Associate
 
 
 
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Contact

 

anat.melamed07

 
 
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Location

 

VD1Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Melamed:2022:10.1126/sciadv.abm6210,
author = {Melamed, A and Fitzgerald, T and Wang, Y and Ma, J and Birney, E and Bangham, C},
doi = {10.1126/sciadv.abm6210},
journal = {Science Advances},
title = {Selective clonal persistence of human retroviruses in vivo: radial chromatin organization, integration site and host transcription},
url = {http://dx.doi.org/10.1126/sciadv.abm6210},
volume = {8},
year = {2022}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - The human retroviruses HTLV-1 and HIV-1 persist in vivo as a reservoir of latently infected T-cell clones. It is poorly understood what determines which clones survive in the reservoir. We compared >160,000 HTLV-1 integration sites (>40,000 HIV-1 sites) from T-cells isolated ex vivo from naturally-infected subjects with >230,000 HTLV-1 integration sites (>65,000 HIV-1 sites) from in vitro infection, to identify genomic features that determineselective clonal survival. Three statistically independent factors together explained >40% of the observed variance in HTLV-1 clonal survival in vivo: the radial intranuclear position of the provirus, its genomic distance from the centromere, and the intensity of local host genome transcription. The radial intranuclear position of the provirus and its distance from the centromere also explained ~7% of clonal persistence of HIV-1 in vivo. Selection for theintranuclear and intrachromosomal location of the provirus, and host transcription intensity, favours clonal persistence of human retroviruses in vivo.
AU  - Melamed,A
AU  - Fitzgerald,T
AU  - Wang,Y
AU  - Ma,J
AU  - Birney,E
AU  - Bangham,C
DO  - 10.1126/sciadv.abm6210
PY  - 2022///
SN  - 2375-2548
TI  - Selective clonal persistence of human retroviruses in vivo: radial chromatin organization, integration site and host transcription
T2  - Science Advances
UR  - http://dx.doi.org/10.1126/sciadv.abm6210
UR  - http://hdl.handle.net/10044/1/96102
VL  - 8
ER  -
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