Imperial College London
ANAT MELAMED

ANAT MELAMED

Faculty of Medicine, Department of Infectious Disease

Research Associate
 
 
 
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Contact

 

anat.melamed07

 
 
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Location

 

VD1Medical SchoolSt Mary's Campus

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Summary

 

Publications

Citation

BibTex format

@article{Cook:2017:10.1016/j.coviro.2017.07.013,
author = {Cook, L and Melamed, A and Yaguchi, H and Bangham, CR},
doi = {10.1016/j.coviro.2017.07.013},
journal = {Current Opinion in Virology},
pages = {125--131},
title = {The impact of HTLV-1 on the cellular genome.},
url = {http://dx.doi.org/10.1016/j.coviro.2017.07.013},
volume = {26},
year = {2017}
}
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RIS format (EndNote, RefMan)

TY  - JOUR
AB  - Human T-lymphotropic virus type-1 (HTLV-1) is the causative agent of adult T-cell leukaemia/lymphoma (ATL), an aggressive CD4+ T-cell malignancy. The mechanisms of leukaemogenesis in ATL are incompletely understood. Insertional mutagenesis has not previously been thought to contribute to the pathogenesis of ATL. However, the recent discovery that HTLV-1 binds the key chromatin architectural protein CTCF raises the hypothesis that HTLV-1 deregulates host gene expression by causing abnormal chromatin looping, bringing the strong HTLV-1 promoter-enhancer near to host genes that lie up to 2Mb from the integrated provirus. Here we review current opinion on the mechanisms of oncogenesis in ATL, with particular emphasis on the local and distant impact of HTLV-1 on the structure and expression of the host genome.
AU  - Cook,L
AU  - Melamed,A
AU  - Yaguchi,H
AU  - Bangham,CR
DO  - 10.1016/j.coviro.2017.07.013
EP  - 131
PY  - 2017///
SN  - 1879-6265
SP  - 125
TI  - The impact of HTLV-1 on the cellular genome.
T2  - Current Opinion in Virology
UR  - http://dx.doi.org/10.1016/j.coviro.2017.07.013
UR  - https://www.ncbi.nlm.nih.gov/pubmed/28822906
UR  - http://hdl.handle.net/10044/1/50177
VL  - 26
ER  -
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