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@article{Miguel-Aliaga:2020:10.1038/s41586-020-2866-8,
author = {Miguel-Aliaga, I and Hadjieconomou, D and King, G and Gaspar, P and Mineo, A and Blackie, L and Ameku, T and Studd, C and de, Mendoza A and Diao, F and White, BH and Brown, A and Placais, P-Y and Preat, T},
doi = {10.1038/s41586-020-2866-8},
journal = {Nature},
pages = {455--459},
title = {Enteric neurons increase maternal food intake during reproduction},
url = {http://dx.doi.org/10.1038/s41586-020-2866-8},
volume = {587},
year = {2020}
}

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TY  - JOUR
AB  - Reproduction induces increased food intake across females of many animal species1,2,3,4, providing a physiologically relevant paradigm for the exploration of appetite regulation. Here, by examining the diversity of enteric neurons in Drosophila melanogaster, we identify a key role for gut-innervating neurons with sex- and reproductive state-specific activity in sustaining the increased food intake of mothers during reproduction. Steroid and enteroendocrine hormones functionally remodel these neurons, which leads to the release of their neuropeptide onto the muscles of the crop—a stomach-like organ—after mating. Neuropeptide release changes the dynamics of crop enlargement, resulting in increased food intake, and preventing the post-mating remodelling of enteric neurons reduces both reproductive hyperphagia and reproductive fitness. The plasticity of enteric neurons is therefore key to reproductive success. Our findings provide a mechanism to attain the positive energy balance that sustains gestation, dysregulation of which could contribute to infertility or weight gain.
AU  - Miguel-Aliaga,I
AU  - Hadjieconomou,D
AU  - King,G
AU  - Gaspar,P
AU  - Mineo,A
AU  - Blackie,L
AU  - Ameku,T
AU  - Studd,C
AU  - de,Mendoza A
AU  - Diao,F
AU  - White,BH
AU  - Brown,A
AU  - Placais,P-Y
AU  - Preat,T
DO  - 10.1038/s41586-020-2866-8
EP  - 459
PY  - 2020///
SN  - 0028-0836
SP  - 455
TI  - Enteric neurons increase maternal food intake during reproduction
T2  - Nature
UR  - http://dx.doi.org/10.1038/s41586-020-2866-8
UR  - https://www.nature.com/articles/s41586-020-2866-8
UR  - http://hdl.handle.net/10044/1/82205
VL  - 587
ER  -

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